Preeclampsia in healthy women and endothelial dysfunction 10 years later

Sandvik, Miriam Kristine; Leirgul, Elisabeth; Nygård, Ottar; Ueland, Per Magne; Berg, Ansgar; Svarstad, Einar; Vikse, Bjørn Egil

doi:10.1016/j.ajog.2013.07.024

Cited by 63 publications

(65 citation statements)

References 52 publications

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“…Another study looked at CVD risk factors 10 years after preeclampsia in otherwise healthy women, defined as no diabetes, rheumatic disease, hypertension, renal disease, CVD, or previous preeclamptic pregnancies. 70 While preeclampsia in previously healthy women was not associated with more traditional risk factors, such as BMI, intima-media thickness, and fat mass, these women were more likely to have lower high-density lipoprotein cholesterol and elevated markers of endothelial dysfunction (urate and sFlt-1), supporting the association of preeclampsia, vascular dysfunction, and future CVD risk in women. 70 After pregnancy, women with a history of preeclampsia display a wide range of differences in CVD risk compared to women with a history of normotensive pregnancies.…”

Section: Preeclampsia and Cvd Riskmentioning

confidence: 87%

“…70 While preeclampsia in previously healthy women was not associated with more traditional risk factors, such as BMI, intima-media thickness, and fat mass, these women were more likely to have lower high-density lipoprotein cholesterol and elevated markers of endothelial dysfunction (urate and sFlt-1), supporting the association of preeclampsia, vascular dysfunction, and future CVD risk in women. 70 After pregnancy, women with a history of preeclampsia display a wide range of differences in CVD risk compared to women with a history of normotensive pregnancies. 71 A meta-analysis of 15 studies found that women with a history of hypertension in pregnancy had elevated biochemical CVD risk factors, including glucose (10 studies), insulin (5 studies), total cholesterol (11 studies), low-density lipoprotein (10 studies), and triglycerides (10 studies).…”

Section: Preeclampsia and Cvd Riskmentioning

confidence: 87%

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Preeclampsia and Vascular Function: A Window to Future Cardiovascular Disease Risk

Enkhmaa

Wall

Mehta

et al. 2016

Journal of Women's Health

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Preeclampsia affects *3%-7% of all pregnancies and is the third leading cause of maternal mortality globally. Growing evidence indicates that preeclampsia results from vascular dysfunction, which also increases the risk for future cardiovascular events. Until recently, preeclampsia was considered a disorder limited to pregnancy, which fully resolved with the delivery of the placenta; however, it is now clear that women with a history of preeclampsia have approximately double the risk of future cardiovascular events compared to women with normotensive pregnancies. The aims of this review were to describe the hemodynamic and vascular changes that occur in normal and preeclamptic pregnancies, to review noninvasive methods to test vascular function, and to discuss the associated increased cardiovascular disease risk related to preeclampsia.

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Section: Preeclampsia and Cvd Riskmentioning

confidence: 87%

Section: Preeclampsia and Cvd Riskmentioning

confidence: 87%

Preeclampsia and Vascular Function: A Window to Future Cardiovascular Disease Risk

Enkhmaa

Wall

Mehta

et al. 2016

Journal of Women's Health

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“…Binding of these antibodies to the angiotensin 1 receptor has been shown to induce endothelial damage and may be a mechanistic link between preeclampsia and subsequent CVD risk 34. However, the relationship between preeclampsia and endothelial dysfunction is controversial, as other studies have failed to find an association between preeclampsia and functional markers of endothelial dysfunction, such as flow‐mediated dilation 35, 36. Moreover, these studies are small and limited in duration of follow‐up.…”

Section: Pathophysiology and Risk Factorsmentioning

confidence: 99%

Hypertensive Disorders of Pregnancy and Future Maternal Cardiovascular Risk

Ying

Catov

Ouyang

2018

JAHA

162

116

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“…[43][44][45][46][47] Subclinical atherosclerosis is commonly assessed by carotid intima-media thickness (cIMT), coronary artery calcium score (CACS), coronary computed tomography angiography (CCTA) and cardiac magnetic resonance imaging (CMR). [5,[46][47][48][49][50][51][52][53][54][55][56][57][58] In recent years, some groups have started to evaluate these imaging techniques in former preeclampsia patients, as discussed below.…”

Section: Cardiovascular Imagingmentioning

confidence: 99%

“…In most studies, cIMT is increased in women after an episode of a hypertensive pregnancy [5, 49-51, 53, 55], although numbers are small and one study could not confirm these findings. [54] Furthermore, the added value of including cIMT in the current risk profiles in the general population is uncertain and it is not likely to improve risk classification. [15,65] Given the limited data available, it is unknown to what extend cIMT contributes to risk classification in formerly preeclamptic women.…”

Section: Carotid Intima-media Thicknessmentioning

confidence: 99%

Determinants of future cardiovascular health in women with a history of preeclampsia

et al. 2015

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Please cite this article as: Zoet Gerbrand A, Koster Maria PH, Velthuis Birgitta K, de Groot Christianne JM, Maas Angela HEM, Fauser Bart CJM, Franx Arie, Rijn Bas B.van.Determinants of future cardiovascular health in women with a history of preeclampsia.Maturitas http://dx.doi.org/10.1016/j.maturitas. 2015.07.004 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Keywords:Preeclampsia, cardiovascular disease, risk assessment, screening, prevention Highlights  Female-specific risk factors, among which preeclampsia, may have additional value in cardiovascular screening.  Non-invasive imaging techniques can be helpful to detect early-stage cardiovascular lesions as a sign of subclinical atherosclerotic disease.  Preliminary studies show positive effects of short-term lifestyle interventions following preeclampsia.  There is a need for clinical practice guidelines that provide long-term strategies in women after preeclampsia in pregnancy to improve cardiovascular health. AbstractWomen who develop preeclampsia have an increased risk of cardiovascular disease (CVD) later in life.However, current guidelines on cardiovascular risk assessment and prevention are unclear on how and when to screen these women postpartum, and about the role of a positive history of preeclampsia in later-life CVD risk management. The aim of this review is to discuss the present knowledge on commonly used cardiovascular screening modalities available to women with a history of preeclampsia, and to discuss recent developments in early detection of CVD using cardiovascular imaging.Furthermore, we explore how female-specific risk factors may have additional value in cardiovascular screening, in particular in relatively young women, although their implementation in clinical practice is challenged by inconsistent results and lack of long-term outcome data. Non-invasive imaging techniques, e.g. coronary artery intima-media thickness (CIMT), can be helpful to detect subclinical atherosclerotic disease, and coronary artery calcium scoring (CACS) has shown to be effective in early detection of cardiovascular damage. However, whilst more short-term and long-term follow-up studies are becoming available, few studies have investigated women with a history of preeclampsia in the fourth and fifth decade of life, when early signs of premature CVD are most likely to become apparent.Further studies are needed to inform new and improved clinical practice guidelines, and provide longterm strategies to effectively prevent CVD, specifically targeted at women with a history of preeclampsia. Additionally, evaluation of feasibility, cost-effectiveness ...

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Preeclampsia in healthy women and endothelial dysfunction 10 years later

Cited by 63 publications

References 52 publications

Preeclampsia and Vascular Function: A Window to Future Cardiovascular Disease Risk

Preeclampsia and Vascular Function: A Window to Future Cardiovascular Disease Risk

Hypertensive Disorders of Pregnancy and Future Maternal Cardiovascular Risk

Determinants of future cardiovascular health in women with a history of preeclampsia

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