Preeclampsia – a risk factor for osteoporosis? Analysis of maternal Sclerostin levels and markers of bone turnover in patients with pre-eclampsia

Wild, Julia; Pateisky, Petra; Küssel, L; Huf, Wolfgang; Ott, Johannes; Haslinger, Peter; Knöfler, Martin; Zeisler, Harald

doi:10.3109/10641955.2014.880455

Cited by 5 publications

(1 citation statement)

References 25 publications

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“…Women with a history of preeclampsia (PE), who have estrogen exposure that is comparable to the general population, can be seen as an intermediate group in both estrogen exposure and BD. Studies have shown that women with a history of PE have a normal BD ( 18 , 19 , 20 , 21 ).…”

Section: Introductionmentioning

confidence: 99%

Trabecular bone density in middle-aged women with reproductive disorders

van Zwol-Janssens,

Hage,

van der Ham

et al. 2023

Endocrine Connections

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Besides age, estrogen exposure plays a crucial role in changes in bone density (BD) in women. Premature ovarian insufficiency (POI) and polycystic ovary syndrome (PCOS) are conditions in reproductive-aged women in which the exposure to estrogen is substantially different. Women with a history of preeclampsia (PE) are expected to have normal estrogen exposure. Within the CREw-IMAGO study, we investigated if trabecular BD is different in these women because of differences in the duration of estrogen exposure. Trabecular BD was measured in thoracic vertebrae on coronary CT scans. Women with an reduced estrogen exposure (POI) have a lower BD compared to women with an intermediate exposure (PE) (mean difference (MD) -26.8, 95% confidence interval (CI) -37.2 - -16.3). Women with a prolonged estrogen exposure (PCOS) have the highest BD (MD 15.0, 95% CI 4.3 – 25.7). These results support the hypothesis that the duration of estrogen exposure in these women is associated with trabecular BD.

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