Preeclampsia: A review of the evidence

Jido, TA; Yakasai, Ibrahim Adamu

doi:10.4103/1596-3519.112395

Cited by 56 publications

(58 citation statements)

References 58 publications

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“…Pre‐eclampsia (PE) originates from the placenta, and is associated with maternal morbidity and mortality . The etiology of PE, however, is still not well understood . Whether maternal nutrition influences the chance of developing PE is not clear.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D restores angiogenic balance and decreases tumor necrosis factor‐α in a rat model of pre‐eclampsia

Jing

2016

J of Obstet and Gynaecol

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Section: Introductionmentioning

confidence: 99%

“…2 The etiology of PE, however, is still not well understood. 3 Whether maternal nutrition influences the chance of developing PE is not clear. It was reported that maternal vitamins and minerals could influence angiogenesis in PE.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D restores angiogenic balance and decreases tumor necrosis factor‐α in a rat model of pre‐eclampsia

Jing

2016

J of Obstet and Gynaecol

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“…This may be due to difference in age, diet, and study population. Increase in maternal age is a wellestablished risk factor for the development of preeclampsia (Jido & Yakasai, 2014;Anorlu et al, 2005). As parity increases, age also increases.…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Serum Calcium and Magnesium Level in Preeclamptic and NonPreeclamptic Women in a Tertiary Hospital in Southern Nigeria

Allagoa

Agbo

2018

ESJ

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Background: Calcium and magnesium are two micronutrients whose role in the development of preeclampsia has been investigated over the years. There is paucity of studies on the role of serum levels of calcium and magnesium in the development of preeclampsia in south-south Nigeria. Objective: Our study evaluated the serum level of calcium and magnesium in preeclamptic and non preeclamptic women in a Tertiary Hospital in southsouth Nigeria. Methodology: We carried out a comparative study in which 52 preeclamptic and 52 non preeclamptic women, who satisfied the eligibility criteria, were enrolled for the study. Data entry and statistical analysis was done using statistical software (IBM SPSS® for windows version 21.0). Data were analyzed for mean and standard deviation. Comparison of serum levels of elements between the two groups was performed by student t-test, and P value < 0.05 was considered as statistically significant. Results: The serum calcium level was statistically lower in the women who developed preeclampsia compared to those who did not (8.37±0.91 mg/dl vs 9.33±1.15mg/dl, p<0.001). The serum magnesium level was not statistically different between women who had preeclampsia and those who did not (1.79±0.24mg/dl vs 1.88±0.37mg/dl, p = 0.102). The systolic and diastolic blood pressure showed a significant negative correlation with serum calcium 438 level, unlike serum magnesiun level in those that had preeclampsia. Conclusion: This study showed that women who developed preeclampsia demonstrated reduced serum calcium level and no reduction in serum magnesium level. This study support the hypothesis that hypocalcaemia, unlike hypomagnecaemia, is a possible aetiology of preeclampsia.

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“…Hypertensive disorders in pregnancy cause maternal and perinatal morbidity and mortality [1,2]. About 8.5 million cases of preeclampsia are reported worldwide yearly [3].…”

Section: Introductionmentioning

confidence: 99%

“…In Mexico, eclampsia and preeclampsia are recognized as direct causes of maternal deaths [5]. The etiology and primary pathology of preeclampsia remain elusive [1]. The role of infection in preeclampsia remains controversial.…”

Section: Introductionmentioning

confidence: 99%

Lack of association between Toxoplasma gondii infection and hypertensive disorders in pregnancy: a case–control study in a Northern Mexican population

et al. 2014

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BackgroundThe outcome of pregnancy is often threatened by hypertension disorders, i.e. eclampsia. Rate of infection with the protozoan parasite Toxoplasma gondii can be as high as 80% in pregnant women, and infection acquired during pregnancy can lead to fetal death. Very little is known about a potential association between infections, i.e. those with Toxoplasma gondii, and hypertensive disorders during pregnancy.MethodsThrough a case–control study design, we investigated the presence of anti-Toxoplasma IgG and anti-Toxoplasma IgM antibodies in 146 pregnant women suffering from hypertensive disorders (cases) and 146 age-matched normotensive pregnant women (controls) attending a public hospital in Durango City, Mexico. Obstetric and blood pressure characteristics from cases and controls were also obtained.ResultsSeroprevalence of anti-Toxoplasma IgG antibodies and IgG titers did not differ significantly in controls (8/146; 5.5%) and cases (9/146; 6.2%). Anti-Toxoplasma IgM antibodies were found in 2 (1.2%) controls and none of the cases. Seroprevalence of T. gondii in controls (5.5%) was similar to seroprevalences found in patients with mild preeclampsia (4/27: 14.8%), severe preeclampsia (5/95: 5.3%), eclampsia (0/16: 0%) and HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet count) (0/8: 0%) (P = 0.23).ConclusionsOur results suggest that latent infection with T. gondii is not associated with hypertensive disorders in pregnant women in Northern Mexico. Further studies with larger sample sizes are needed to elucidate the association of infection with T. gondii with hypertensive disorders in pregnancy.

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Preeclampsia: A review of the evidence

Cited by 56 publications

References 58 publications

Vitamin D restores angiogenic balance and decreases tumor necrosis factor‐α in a rat model of pre‐eclampsia

Vitamin D restores angiogenic balance and decreases tumor necrosis factor‐α in a rat model of pre‐eclampsia

Comparative Evaluation of Serum Calcium and Magnesium Level in Preeclamptic and NonPreeclamptic Women in a Tertiary Hospital in Southern Nigeria

Lack of association between Toxoplasma gondii infection and hypertensive disorders in pregnancy: a case–control study in a Northern Mexican population

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