Predrug Behavior as a Predictor of Response to Phenothiazines Among Schizophrenics

Marks, John

doi:10.1097/00005053-196312000-00012

Cited by 13 publications

(3 citation statements)

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“…One approach is to examine the differences between individual pretreatment syndrome scores. Marks (1963), for example, attempted to provide such clues by correlating, for each of several drugs, the predrug symptoms with a "responsiveness score." He found that responsiveness was associated with cooperativeness in Chlorpromazine patients, sociability with perphenazine, activity level with prochlorperazine, and anxiety and tension with triflupromazine.…”

Section: Discussionmentioning

confidence: 99%

The right drug for the right patient.

Klett¹,

Moseley²

1965

Journal of Consulting Psychology

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In chemotherapy, the problem of finding the right drug for the right patient is based upon the premise that drugs have specific actions and that a particular agent may be beneficial for certain patients but not for others. The drug of choice in this study was defined in terms of the best prediction from multiple regression equations developed on groups that had received 3 different tranquilizing drugs, using pretreatment symptomatology as the predictors. Cross-validation of these assignments on an independent sample confirmed the hypothesis that patients respond best if assigned to their drug of choice. Simple random assignment of patients to the different drugs would have led to an acceptance of the null hypothesis.

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Section: Discussionmentioning

confidence: 99%

The right drug for the right patient.

Klett¹,

Moseley²

1965

Journal of Consulting Psychology

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“…Several clinical studies of some of the widely used phenothiazines have reported different degrees of therapeutic effectiveness for different kinds of schizophrenic symptoms. 3765 ' 78 Recent research reports on the experimental drug triperidol by Hollister and his colleagues 5556 - 87 have indicated significantly greater rated improvement among paranoid schizophrenics than among nonparanoid schizophrenics. Furthermore studies by Sugerman and Williams 121 and by Hollister et al 56 suggest that the positive behavioral changes associated with the use of triperidol are related to changes in sensory-perceptual responsiveness.…”

Section: Schizophrenics For Several Pictorial Scenesmentioning

confidence: 99%

Variations in Cognitive Control and Psychophysiological Defense in the Schizophrenias

Silverman¹

1967

Psychosomatic Medicine

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Recent researches in the schizophrenias have led to the identification of systematic relationships between sensory, perceptual, and cognitive response parameters, on the one hand, and on the other, symptom variables and their interactions with "premorbid adjustment" and length of hospitalization variables.Certain psychological and physiological reaction patterns and the mechanisms which appear to underlie them are examined in various schizophrenic and nonschizophrenic groups. These response mechanisms, conceptualized as serving significant defensive and adaptive functions, are shown to assume quite different forms in clinically differentiable schizophrenic subtypes.

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“…The usual dose employed was from 75 to 300 mg. daily in divided doses (6,9,20,40,58,87,89,91,93). Later studies (1,3,10,17,19,23,30,32,33,37,38,43,45,46,47,53,73,77,84,92), some of which employed double blind and placebo controls, clarified t~e position as follows: prochlorperazine has definite neuroleptic activity, i.e. it produces sedation without drowsiness, acts on the hypermobility syndrome and has a tendency to produce extrapyramidal symptoms.…”

Section: Procblorperazine As An Antipsychoticmentioning

confidence: 99%