Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virus

Abstract

Human herpesvirus 6 (HHV-6)-related virus was isolated from CD4+ CD8and CD3+ CD4+ mature T lymphocytes but could not be isolated from CD4-CD8+, CD4-CD8-, and CD3-T cells in the peripheral blood of exanthem subitum patients. HHV-6-related virus predominantly infected CD4+ CD8+, CD4+ CD8- ,

Role of viruses in etiology and pathogenesis of multiple sclerosis

“…HHV-6 is a beta herpesvirus for which seroprevalence rates vary from 72% to 100% in healthy adults worldwide (Yamanishi, 1992;Asano and Grose, 1994;Hall et al, 1994). Although HHV-6 replicates primarily in T lymphocytes, it is a pleiotropic virus that can either productively or nonproductively infect cells from several lineages including B cells, microglia, oligodendrocytes, and astrocytes (Lusso, 1988;Takahashi et al, 1989;He et al, 1996;Albright et al, 1998). Two variants of HHV-6 (HHV-6A and HHV-6B) have been described, and are based on genomic, antigenic, and biological differences .…”

Human herpesvirus 6A induces apoptosis of HSB-2 cells via a mitochondrion-related caspase pathway

“…Human herpesvirus 6 (HHV-6) is a T-lymphotropic virus and the causal agent of exanthem subitum [6][7][8] . HHV-6 is involved in pneumonitis, hepatitis, mononucleosis-like illness and fatal hemophagocytic syndrome.…”

Cell cycle perturbations induced by human herpesvirus 6 infection and their effect on virus replication

“…Human herpesvirus 6 (HHV-6) is a ubiquitous pathogen of the subfamily Betaherpesvirinae, which includes cytomegalovirus and HHV-7, and it primarily infects CD4 ? T cells [32]. Like other herpesviruses, HHV-6 establishes latency after the initial productive infection and thus is never cleared from its host [28].…”