Predominance of the Hungarian clone (ST 239-III) among hospital-acquired meticillin-resistant Staphylococcus aureus isolates recovered throughout mainland China

Xu, BangLao; Zhang, G; Ye, H F; Feil, Edward J.; Chen, G R; Zhou, Xin; Zhan, Xi Mei; Chen, S M; Pan, Wubin

doi:10.1016/j.jhin.2008.10.029

Cited by 35 publications

(28 citation statements)

References 27 publications

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“…The prevalence of MRSA in our study of isolates from a hospital in Shanghai was similar at 72.8 %. In addition, previous studies of the genotypes most common in China and Shanghai revealed that the Brazilian/Hungarian (ST239-MRSA-III) and New York/Japanese (ST5-MRSA-II) clones are the most prevalent nationwide (Chen et al, 2010;Xu, et al, 2009) and that the most common spa types in Shanghai are t002 and t037. Similar to these findings, the predominant types of MRSA isolates in our study were ST239-MRSA-III and t037.…”

Section: Discussionmentioning

confidence: 99%

Phenotypic and molecular characterization of Staphylococcus aureus recovered from different clinical specimens of inpatients at a teaching hospital in Shanghai between 2005 and 2010

Yan

et al. 2013

Journal of Medical Microbiology

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Staphylococcus aureus, including meticillin-sensitive and -resistant S. aureus (MSSA and MRSA, respectively), is associated with severe nosocomial human infections. This study aimed to investigate the molecular profile, including the dynamic changes and genotype/phenotype correlation, of S. aureus isolates recovered from different clinical specimens of inpatients with S. aureus infection over a 6-year span at a teaching hospital in Shanghai, China. Between 2005 and 2010, a random sample of 610 unique S. aureus isolates was collected from different clinical samples of inpatients with S. aureus infection for molecular and antibiotic susceptibility analysis. The results showed that, among the 610 S. aureus isolates, 20 sequence types (STs) determined by multi-locus sequence typing (primarily ST239, ST5, ST7, ST188 and ST398) and 52 spa types (primarily t002, t037, t030 and t601) were found. In total, 444 isolates (72.8 %) were MRSA and 166 (27.2 %) were MSSA. ST239-MRSA-III-spa t037 and ST5-MRSA-II-spa t002 were the predominant MRSA clones. From 2005 to 2010, spa t002, spa t037 and their corresponding STs (ST5 and ST239) were the most frequent clones among all of the S. aureus isolates and showed the most resistant phenotypes to various antibiotics. Generally, the different genotypes showed different drug resistance rates, but no isolates were resistant to vancomycin, teicoplanin or linezolid. The profiles of virulence and resistance genes differed by genetic background, with the ST239 and ST5 strains showing higher resistance rates to gentamicin, cefoxitin, ampicillin, cefazolin, erythromycin, clindamycin and levofloxacin than strains of other types. Moreover, the antiseptic resistance genes qacA/B were generally associated with these two types. The prevalence of STs was different among different clinical specimens and also changed by year. Recently (2009Recently ( -2010, the distribution of predominant MRSA clones decreased, whilst the prevalence of non-predominant MSSA clones increased, especially for the isolates causing bacteraemia. Continual monitoring of clinical isolates is necessary to develop and maintain an effective strategy against S. aureus infection in the hospital setting.

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Section: Discussionmentioning

confidence: 99%

Phenotypic and molecular characterization of Staphylococcus aureus recovered from different clinical specimens of inpatients at a teaching hospital in Shanghai between 2005 and 2010

Yan

et al. 2013

Journal of Medical Microbiology

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“…Therefore, it was described as highly transmissible MRSA [59,60]. ST239 HA-MRSA is a growing MRSA group, which includes at least nine members (EMRSA-1, EM-RSA-4, EMRSA-7, EMRSA-11, and the Brazilian, Portuguese, Hungarian, Viennese, and Russian clones), and is widely spreading in Asia, South America, and Eastern Europe [44,[61][62][63][64][65][66].…”

Section: Ha-mrsamentioning

confidence: 99%

Community-acquired methicillin-resistant Staphylococcus aureus: community transmission, pathogenesis, and drug resistance

Yamamoto

Nishiyama

Takano

et al. 2010

Journal of Infection and Chemotherapy

129

167

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Methicillin-resistant Staphylococcus aureus (MRSA) is able to persist not only in hospitals (with a high level of antimicrobial agent use) but also in the community (with a low level of antimicrobial agent use). The former is called hospital-acquired MRSA (HA-MRSA) and the latter community-acquired MRSA (CA-MRSA). It is believed MRSA clones are generated from S. aureus through insertion of the staphylococcal cassette chromosome mec (SCCmec), and outbreaks occur as they spread. Several worldwide and regional clones have been identified, and their epidemiological, clinical, and genetic characteristics have been described. CA-MRSA is likely able to survive in the community because of suitable SCCmec types (type IV or V), a clone-specific colonization/infection nature, toxin profiles (including Pantone-Valentine leucocidin, PVL), and narrow drug resistance patterns. CA-MRSA infections are generally seen in healthy children or young athletes, with unexpected cases of diseases, and also in elderly inpatients, occasionally surprising clinicians used to HA-MRSA infections. CA-MRSA spreads within families and close-contact groups or even through public transport, demonstrating transmission cores. Re-infection (including multifocal infection) frequently occurs, if the cores are not sought out and properly eradicated. Recently, attention has been given to CA-MRSA (USA300), which originated in the US, and is growing as HA-MRSA and also as a worldwide clone. CA-MRSA infection in influenza season has increasingly been noted as well. MRSA is also found in farm and companion animals, and has occasionally transferred to humans. As such, the epidemiological, clinical, and genetic behavior of CA-MRSA, a growing threat, is focused on in this study.

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“…Multilocus sequence typing (MLST) identified TW20 as sequence type 239 (ST239), an international health care-associated (HA) MRSA lineage prevalent in Asia (19,38), South America (2, 37), and Eastern Europe (5,33), which includes EMRSA-1, -4, -7, and -11 and the Brazilian, Portuguese, Hungarian, and Viennese clones (24). To investigate the genetic basis for increased resistance and transmissibility, the TW20 genome was completely sequenced, assembled, and finished and annotated as described previously (16,25).…”

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confidence: 99%

Genome Sequence of a Recently Emerged, Highly Transmissible, Multi-Antibiotic- and Antiseptic-Resistant Variant of Methicillin-Resistant Staphylococcus aureus , Sequence Type 239 (TW)

et al. 2010

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Predominance of the Hungarian clone (ST 239-III) among hospital-acquired meticillin-resistant Staphylococcus aureus isolates recovered throughout mainland China

Cited by 35 publications

References 27 publications

Phenotypic and molecular characterization of Staphylococcus aureus recovered from different clinical specimens of inpatients at a teaching hospital in Shanghai between 2005 and 2010

Phenotypic and molecular characterization of Staphylococcus aureus recovered from different clinical specimens of inpatients at a teaching hospital in Shanghai between 2005 and 2010

Community-acquired methicillin-resistant Staphylococcus aureus: community transmission, pathogenesis, and drug resistance

Genome Sequence of a Recently Emerged, Highly Transmissible, Multi-Antibiotic- and Antiseptic-Resistant Variant of Methicillin-Resistant Staphylococcus aureus , Sequence Type 239 (TW)

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