Predominance of Rotavirus Genotype G9 during the 1999, 2000, and 2002 Seasons among Hospitalized Children in the City of Salvador, Bahia, Brazil: Implications for Future Vaccine Strategies

Santos, Norma; Volotão, Eduardo de Mello; Soares, Caroline C.; Campos, Gúbio Soares; Sardi, Silvia Inês; Hoshino, Yasutaka

doi:10.1128/jcm.43.8.4064-4069.2005

Cited by 65 publications

(63 citation statements)

References 44 publications

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“…In Brazil, several studies have reported frequencies of rotavirus infection between 20-70%, especially in younger children (Santos et al 2002, Luz et al 2005, Carvalho-Costa et al 2006. Our results are comparable to those from large cities of different states which showed the occurrence of rotavirus at a rate of approximately 23% among infants hospitalized for acute diar- Number of positive (Frequency %) Number of positive (Frequency %) rhea.…”

Section: Discussionsupporting

confidence: 78%

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Rotavirus and adenovirus in Rondônia

Magalhães

Nogueira

Grava

et al. 2007

Mem. Inst. Oswaldo Cruz

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Section: Discussionsupporting

confidence: 78%

“…In Brazil, frequencies of rotavirus infection between 20-70% have been reported especially in younger children (Santos et al 2002, Luz et al 2005, Carvalho-Costa et al 2006.…”

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confidence: 99%

Rotavirus and adenovirus in Rondônia

Magalhães

Nogueira

Grava

et al. 2007

Mem. Inst. Oswaldo Cruz

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“…The first period included 653 RV-A-positive samples that were collected from 1982-1995; these cases were reported in 15 papers in our literature review (Linhares et al 1988, Stewien et al 1994, Gusmão et al 1995, Leite et al 1996, Mascarenhas et al 1998, Cardoso et al 2000, 2001, Carmona et al 2004. The second period included 1,839 RV-A-positive samples that were collected from 1996-2005; these cases were reported in 19 articles in our literature review (Santos et al 1998, 2005b, Araújo et al 2002, Rosa-e-Silva et al 2002, Souza et al 2003, Luz et al 2005, Carmona et al 2006, Carvalho-Costa et al 2006, 2009, Pietruchinski et al 2006, Andreasi et al 2007, Gouvea et al 2007, Montenegro et al 2007, Martini et al 2008, Domingues et al 2008, Ribeiro et al 2008. Altogether, during the pre-vaccination era, 2,492 RV-A-positive faecal samples were typed, either by use of monoclonal antibody or PCR assays.…”

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confidence: 99%

Group A rotavirus genotypes and the ongoing Brazilian experience: a review

Leite

Carvalho-Costa

Linhares

2008

Mem. Inst. Oswaldo Cruz

102

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Brazil was the first Latin American country to introduce universal group A rotavirus (RV-A) vaccination in March 2006, resulting in a unique epidemiological scenario. Since RV-A first identification in Brazil, 2,691 RV-A-positive stool samples, collected between 1982- 2007, were typed by independent research groups throughout the country. In the pre-vaccination era, 2,492 RV-A-positive samples collected from 1982-2005 were successfully typed, while 199 samples were analyzed from 2006-2007. According to the reviewed studies, there were two important times in the pre-vaccination era: (i) the period from 1982-1995, during which the detection of G5P[8] RV-A, in addition to the classical genotypes G1-4, challenged vaccine development programs; and (ii) the period from 1996-2005, during which genotype G9P[8] emerged, following a global trend. The rate of G2P[4] RV-A detection decreased from 26% (173/653) during 1982-1995 to 2% (43/1,839) during 1996-2005. The overall detection rate of RV-A genotypes from 1982-2005 was as follows: 43% (n = 1,079) G1P[8]/G1P[not typed (NT)]; 20% (n = 488) G9P[8]/G9P[NT]; 9% (n = 216) G2P[4]/G2P[NT]; 6% (n = 151) G3P[8]/G3P[NT]; 4% (n = 103) G4P[8]/G4P[NT]; and 4% (n = 94) G5P[8]/G5P[NT]. Mixed infections accounted for 189 (7%) of the positive samples, while atypical G/P combinations or other genotypes, including G6, G8, G10 and G12, were identified in 172 (7%) samples. The initial surveillance studies carried out in several Brazilian states with RV-A-positive samples collected in 2006 and 2007 show a predominance of G2P[4] strains (148/199 or 74%). Herein, we review RV-A typing studies carried out since the 1980s in Brazil, highlighting the dynamics of RV-A strain circulation profiles before and early after universal use of RV-A vaccine in Brazil

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“…However, only five G-and-P-type combinations have been commonly associated with human rotaviruses (2,3). They are G1P [8], G2P [4], G3P [8], G4P [8], and G9P [8]. Less common combinations, thought to have originated from animal rotaviruses, have also been identified (2,4).…”

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confidence: 99%

“…They are G1P [8], G2P [4], G3P [8], G4P [8], and G9P [8]. Less common combinations, thought to have originated from animal rotaviruses, have also been identified (2,4). These include human rotaviruses expressing G8, G10, G11, or G12 G types.…”

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confidence: 99%

Identification by Full-Genome Analysis of a Bovine Rotavirus Transmitted Directly to and Causing Diarrhea in a Human Child

et al. 2013

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The genome of rotaviruses consists of 11 segments of double-stranded RNA, and each genome segment has multiple genotypes. Thus, the genotype constellation of an isolate is often indicative of its host species. Albeit rarely, interspecies transmission occurs either by virions with nonreassorted or reassorted genomic segments. A rotavirus with the G6P[1] genotype, Ro8059, was isolated from the stool of a 1-year-old child during routine characterization of diarrheal specimens from a sentinel clinic in Israel in 1995. Since genotype G6P[1] is generally associated with bovine rotaviruses, and the child developed diarrhea within days of his first contact with calves at an urban farm, the aim of this study was to characterize the whole genomic constellation of Ro8059 and four G6P[1] bovine strains, BRV101, BRV105, BRV106, and CR231/39, by RNA-RNA hybridization and full genome sequencing to determine whether some or all of the segments were of bovine origin. The genome constellations of all four bovine G6P[1] strains were G6-P[1]-I2-R2-C2-M2-A3-N2-T6-E2-H3 for VP7-VP4-VP6-VP1-VP2-VP3-NSP1-NSP2-NSP3-NSP4-NSP5, respectively. Ro8059 shared the same genotype constellation with these bovine strains, with high nucleotide sequence identities (95.84 to 100%) for each of the 11 segments indicating that Ro8059 represented a direct interspecies whole-genome transmission of a nonreassorted rotavirus from a calf to a human infant. We conclude that this was the earliest example with a complete epidemiological link in which an entirely bovine rotavirus directly infected a human child and caused a symptomatic diarrheal illness. Thus, not all bovine rotaviruses are always naturally attenuated to the human host.

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Predominance of Rotavirus Genotype G9 during the 1999, 2000, and 2002 Seasons among Hospitalized Children in the City of Salvador, Bahia, Brazil: Implications for Future Vaccine Strategies

Cited by 65 publications

References 44 publications

Rotavirus and adenovirus in Rondônia

Rotavirus and adenovirus in Rondônia

Group A rotavirus genotypes and the ongoing Brazilian experience: a review

Identification by Full-Genome Analysis of a Bovine Rotavirus Transmitted Directly to and Causing Diarrhea in a Human Child

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