Predominance of Nootropic or Anxiolytic Effects of Selank, Semax, and Noopept Peptides Depending on the Route of Administration to BALB/c and С57BL/6 Mice

Васильева, Е. В.; Kondrakhin, E. A.; Abdullina, A. A.; Salimov, R. M.; Ковалев, Г. И.

doi:10.1134/s1819712420030113

Cited by 6 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because only male mice were tested in the PA assay, we currently do not know the procognitive effects in female mice, which is a limitation of this study. Interestingly, nootropics showing procognitive effects in the PA tests often also show anxiolytic-like effects 35 , in agreement with our observation in the EPM. To further explore the mechanisms of the procognitive effects of scoparone, we applied two different amnesia models related to scopolamine and LPS treatment, respectively.…”

Section: Discussionsupporting

confidence: 90%

Neuropsychopharmacological profiling of scoparone in mice

Kowalczyk

Budzyńska

Kurach

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Scoparone (6,7-dimethoxycoumarin) is a simple coumarin from botanical drugs of Artemisia species used in Traditional Chinese Medicine and Génépi liquor. However, its bioavailability to the brain and potential central effects remain unexplored. We profiled the neuropharmacological effects of scoparone upon acute and subchronic intraperitoneal administration (2.5–25 mg/kg) in Swiss mice and determined its brain concentrations and its effects on the endocannabinoid system (ECS) and related lipids using LC–ESI–MS/MS. Scoparone showed no effect in the forced swimming test (FST) but, administered acutely, led to a bell-shaped anxiogenic-like behavior in the elevated plus-maze test and bell-shaped procognitive effects in the passive avoidance test when given subchronically and acutely. Scoparone rapidly but moderately accumulated in the brain (Cmax < 15 min) with an apparent first-order elimination (95% eliminated at 1 h). Acute scoparone administration (5 mg/kg) significantly increased brain arachidonic acid, prostaglandins, and N-acylethanolamines (NAEs) in the FST. Conversely, subchronic scoparone treatment (2.5 mg/kg) decreased NAEs and increased 2-arachidonoylglycerol. Scoparone differentially impacted ECS lipid remodeling in the brain independent of serine hydrolase modulation. Overall, the unexpectedly potent central effects of scoparone observed in mice could have toxicopharmacological implications for humans.

show abstract

Section: Discussionsupporting

confidence: 90%

Neuropsychopharmacological profiling of scoparone in mice

Kowalczyk

Budzyńska

Kurach

et al. 2022

Sci Rep

View full text Add to dashboard Cite

show abstract

“…α-MSH has also been shown to reduce the activation of NMDAR and non-NMDAR (AMPAR and/or metabotropic group I glutamate receptors) in rat striatal slices [ 289 ]. In ex vivo binding studies in mice, peripheral administration of Semax has been shown to decrease the density of hippocampal NMDAR [ 290 ].…”

Section: The Glutamate Hypothesis Of Depression and Melanocortinsmentioning

confidence: 99%

The Melanocortin System: A Promising Target for the Development of New Antidepressant Drugs

Markov

Долотов

Гривенников

2023

IJMS

View full text Add to dashboard Cite

Major depression is one of the most prevalent mental disorders, causing significant human suffering and socioeconomic loss. Since conventional antidepressants are not sufficiently effective, there is an urgent need to develop new antidepressant medications. Despite marked advances in the neurobiology of depression, the etiology and pathophysiology of this disease remain poorly understood. Classical and newer hypotheses of depression suggest that an imbalance of brain monoamines, dysregulation of the hypothalamic-pituitary-adrenal axis (HPAA) and immune system, or impaired hippocampal neurogenesis and neurotrophic factors pathways are cause of depression. It is assumed that conventional antidepressants improve these closely related disturbances. The purpose of this review was to discuss the possibility of affecting these disturbances by targeting the melanocortin system, which includes adrenocorticotropic hormone-activated receptors and their peptide ligands (melanocortins). The melanocortin system is involved in the regulation of various processes in the brain and periphery. Melanocortins, including peripherally administered non-corticotropic agonists, regulate HPAA activity, exhibit anti-inflammatory effects, stimulate the levels of neurotrophic factors, and enhance hippocampal neurogenesis and neurotransmission. Therefore, endogenous melanocortins and their analogs are able to complexly affect the functioning of those body’s systems that are closely related to depression and the effects of antidepressants, thereby demonstrating a promising antidepressant potential.

show abstract