Predominance of delta variant among the COVID-19 vaccinated and unvaccinated individuals, India, May 2021

Abstract

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Clinical Characterization and Genomic Analysis of Samples from COVID-19 Breakthrough Infections during the Second Wave among the Various States of India

“…Breakthrough infections in healthcare workers vaccinated with the BNT162b2 vaccine were reported from Italy in the May 2021 during an outbreak of SARS-CoV-2 lineage B.1.1.7 [19]. In India, a few studies reported breakthrough infections in small parts of the country, such as in Kerala [20], Chennai [21], and Delhi [22]. Taking cognizance of such reports, in April-May 2021, a nationwide study was undertaken to understand the clinico-demographic profile of patients and SARS-CoV-2 strains responsible for post-vaccination breakthrough COVID-19 infections across the country.…”

The efficacy of COVID-19 vaccines against the B.1.617.2 (delta) variant

“…They comprised 7 clinical trials, 3 categories of vaccine (comprising 6 different vaccines), and a total of 504,781 cases (69,315 versus 435,466). [2][3][4][5][6][7][8] A meta-analysis was performed using R statistical software (details are shown in supplemental information, Figure S1, and Table S1). 9 We first investigated the efficacy of COVID-19 vaccines against overall infection by the delta variant.…”

Limited Impact of Delta Variant’s Mutations on the Effectiveness of Neutralization Conferred by Natural Infection or COVID-19 Vaccines in a Latino Population

“…Recent studies suggested that the Delta variant may infect vaccinated individuals, creating what are defined as breakthrough infections [38]. In vitro neutralization results using monoclonal antibodies argue that vaccination induces a low level of nAbs against the Delta variant [11,35,39].…”

“…Nonetheless, vaccination is still considered the most effective way of preventing severe disease and mortality. Vaccination, along with natural herd immunity, is our ticket to restoring our lives to some sense of normalcy, and it needs to advance, along with epidemiological and genomic surveillance, as a means to counter progressing SARS-CoV-2 fitness [38].…”