1992
DOI: 10.1177/019262339202000103
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Prednisone is Not a Mouse Carcinogen

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Cited by 12 publications
(10 citation statements)
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“…About 20% of cells in the inner cortex showed cellular degeneration and the accumulation of rounded vacuolated cell debris, membranous material and pigment. 156 This was also characterized by the presence of degeneration and accumulation of large cells containing abundant golden brown pigment at the corticomedullary junction, i.e. Similar findings have been reported in dogs treated with other glucocorticoids for prolonged periods.…”
Section: Atrophy Of the Zona Fasciculata And Reticularissupporting
confidence: 71%
“…About 20% of cells in the inner cortex showed cellular degeneration and the accumulation of rounded vacuolated cell debris, membranous material and pigment. 156 This was also characterized by the presence of degeneration and accumulation of large cells containing abundant golden brown pigment at the corticomedullary junction, i.e. Similar findings have been reported in dogs treated with other glucocorticoids for prolonged periods.…”
Section: Atrophy Of the Zona Fasciculata And Reticularissupporting
confidence: 71%
“…It has been reported that body weight loss in rodents treated with corticosteroids is caused by their systemic catabolic effects. 18 20 Although systemic exposure to the TCSs was not measured in the present study, the body weight loss in the DF group was considered possibly related to a systemic effect of DF of very strong potency compared to PV (medium potency) and BV (strong potency). Difference in clinical efficacy/potency may explain why the body weight loss was seen only in the DF group.…”
Section: Discussionmentioning
confidence: 90%
“…It has been reported that body weight loss in rodents treated with corticosteroids is caused by their systemic catabolic effects. [18][19][20] Although systemic exposure to the TCSs was not measured in the present study, the body weight loss in the DF group was considered , and DF (F). Cldn-1 positivity was seen in the suprabasal layer in the epidermis (A).…”
Section: Discussionmentioning
confidence: 99%
“…This study highlights temporal changes in the adrenal glands of offspring and the emergence of specific abnormalities with ageing as evidenced by the fact that at 12 months of age, male offspring of Cort-exposed dams had an increased number of adrenal plaques. These deposits have been shown to be associated not only with ageing (Rosol et al 2001) but also elevated corticosteroid levels (Schardein et al 1967, Dunn 1970, Dillberger et al 1992.…”
Section: :1mentioning
confidence: 99%