Prednisolone Trimethylacetate in Intra-articular Therapy

Murdoch, W. R.; Will, George F.

doi:10.1136/bmj.1.5132.1267

BMJ

1959

DOI: 10.1136/bmj.1.5132.1267

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Prednisolone Trimethylacetate in Intra-articular Therapy

W. R. Murdoch¹,

George F. Will²

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Cited by 6 publications

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References 14 publications

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“…While undertaking a clinical trial of prednisolone trimethylacetate (Murdoch and Will, 1959) we decided to make observations on the cytological and biochemical characters of the synovial fluid in an attempt to detect changes which might occur, and to establish their possible relationship to clinical improvement.…”

mentioning

confidence: 99%

Synovial Fluid Changes in Intra-articular Therapy

Murdoch¹,

Will²

1959

BMJ

Self Cite

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mentioning

confidence: 99%

Synovial Fluid Changes in Intra-articular Therapy

Murdoch¹,

Will²

1959

BMJ

Self Cite

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Intra-articular corticosteroid for knee osteoarthritis

Jüni

Hari

Rutjes

et al. 2015

Cochrane Database of Systematic Reviews

322

302

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Background Knee osteoarthritis is a leading cause of chronic pain, disability, and decreased quality of life. Despite the long-standing use of intraarticular corticosteroids, there is an ongoing debate about their benefits and safety. This is an update of a Cochrane review first published in 2005. Objectives To determine the benefits and harms of intra-articular corticosteroids compared with sham or no intervention in people with knee osteoarthritis in terms of pain, physical function, quality of life, and safety. Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, and EMBASE (from inception to 3 February 2015), checked trial registers, conference proceedings, reference lists, and contacted authors. Selection criteria We included randomised or quasi-randomised controlled trials that compared intra-articular corticosteroids with sham injection or no treatment in people with knee osteoarthritis. We applied no language restrictions. Data collection and analysis We calculated standardised mean differences (SMDs) and 95% confidence intervals (CI) for pain, function, quality of life, joint space narrowing, and risk ratios (RRs) for safety outcomes. We combined trials using an inverse-variance random-effects meta-analysis. Main results We identified 27 trials (13 new studies) with 1767 participants in this update. We graded the quality of the evidence as 'low' for all outcomes because treatment effect estimates were inconsistent with great variation across trials, pooled estimates were imprecise and did not rule out relevant or irrelevant clinical effects, and because most trials had a high or unclear risk of bias. Intra-articular corticosteroids appeared to be more beneficial in pain reduction than control interventions (SMD-0.40, 95% CI-0.58 to-0.22), which corresponds to a difference in pain scores of 1.0 cm on a 10-cm visual analogue scale between corticosteroids and sham injection and translates 1 Intra-articular corticosteroid for knee osteoarthritis (Review)

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Die Corticoide in der Behandlung der Lungentuberkulose

1963

Beiträge zur Klinik der Tuberkulose

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Prednisolone Trimethylacetate in Intra-articular Therapy

Cited by 6 publications

References 14 publications

Synovial Fluid Changes in Intra-articular Therapy

Synovial Fluid Changes in Intra-articular Therapy

Intra-articular corticosteroid for knee osteoarthritis

Die Corticoide in der Behandlung der Lungentuberkulose

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