Prednisolone stimulates hepatic glutathione synthesis in mice

Speck, Roberto F.; Schranz, Christian; Lauterburg, Bernhard H.

doi:10.1016/s0168-8278(05)80010-8

Cited by 18 publications

(5 citation statements)

References 19 publications

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“…6 In protein components of the extracellular matrix, either directly or through the activation of vari-this regard, anticoagulant therapy was reported to suppress the invasion of cancer cells in ex-ous procollagenases such as procollagenase type IV secreted by tumour cells. 9 In this study perimental models and to show survival benefit in some types of lung tumour in humans when the blood concentration of the fibrin degradation fragment -dimer was found to be used in combination with other cytotoxic drugs. 7 Fibrin deposits in lung cancer tissues an independent predictor of survival in patients with lung cancer.…”

Section: Discussionmentioning

confidence: 93%

“…5 The erate plasmin -the active serine protease of the fibrinolysis system -that may act on fibrin biological significance of the activation of the clotting system and fibrinolysis in cancer has in the primary tumours increasing the detachment of cells and their penetration into the recently been discussed with regard to the potential role of these pathways in the patho-circulatory channels. 9 In addition, plasmin may promote tumour invasion by degrading various genesis of malignancy for their ability to regulate tumour growth and dissemination. 6 In protein components of the extracellular matrix, either directly or through the activation of vari-this regard, anticoagulant therapy was reported to suppress the invasion of cancer cells in ex-ous procollagenases such as procollagenase type IV secreted by tumour cells.…”

Section: Discussionmentioning

confidence: 99%

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Attenuation of oxidant/antioxidant imbalance during treatment of exacerbations of chronic obstructive pulmonary disease

Rahman

Skwarska

MacNee

1997

Thorax

133

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Abstractprotein components of the extracellular matrix, activate latent enzymes such as type IV colBackground -The peripheral blood concentrations of several proteases of the clot-lagenase, and dissolve tumour associated fibrin clots. 2 Circulating markers of the fibrinolysis ting system have been shown to predict survival in patients with malignancy. A system are raised in patients with lung cancer and they have been shown to correlate with study was undertaken to investigate the independent value of the plasma levels of tumour burden, clinical progression, and the response to chemotherapy. 3 The aim of this the D-dimer degradation product of fibrin before treatment for predicting prognosis study was to investigate the independent value of the pretreated plasma levels of -dimer fibrin in patients with lung cancer. Methods -The study comprised 70 patients degradation products for predicting prognosis in patients with lung cancer. with lung cancer (49 non-small cell lung cancer and 21 small cell lung cancer). Plasma levels of D-dimer were measured using an enzyme immunoassay kit. Multi-Methods variate statistical analysis was carried Seventy consecutive patients with lung cancer, out using the Cox's proportional hazards of median age 65 years (range 20-83), admitted model.to the Mie University Hospital from July 1990 Results -The median value of the plasma to December 1991 took part in the study. There level of D-dimer differentiated two groups were 49 cases with non-small cell lung cancer of patients with different outcomes: a (non-SCLC) and 21 with small cell lung cancer group with a D-dimer level of <150 ng/ml (SCLC). Clinical staging was performed ac-(low DD group) and those with D-dimer cording to the new international staging system. levels of [150 ng/ml (high DD group). Patients underwent curative surgery (n=20) Survival time was significantly better in or combination chemotherapy followed by patients in the low DD group than in those radiotherapy (n=50). Venous blood samples in the high DD group in all patients (haz-were taken 1-5 days (median two days) before ard ratio for high DD group=4.7; 95% starting any treatment and stored at −80°C confidence interval (CI) 1.8 to 11.7). The until needed. Plasma levels of -dimer were plasma levels of D-dimer predicted sur-determined using an enzyme immunoassay kit vival independently from the clinical stage (Dimertest, Agen, Mountain View, California, of disease, histological type, performance USA). -dimer levels were also measured in status, and tumour size (hazard ratio= blood samples from age matched healthy vo-3.9; 95% CI 1.6 to 9.2).lunteers (n=40) and from patients with benign Conclusions -These results suggest that pulmonary disease (n=25). There was a history plasma levels of D-dimer might be useful of smoking in 50 patients with lung cancer, in for predicting the clinical outcome in 15 with benign disease, and in 10 healthy patients with lung cancer. However, fur-subjects. The intra-assay and inter-assay prether prospective studies are needed in a cisio...

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Attenuation of oxidant/antioxidant imbalance during treatment of exacerbations of chronic obstructive pulmonary disease

Rahman

Skwarska

MacNee

1997

Thorax

133

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“…Although treatment with ICS or oral steroids does not change total and differential cell counts in induced sputum in COPD patients [10, 13], in contrast to asthmatic patients [23], it significantly reduces the chemotactic activity of neutrophils and increases the neutrophil elastase inhibitory capacity in induced sputum [11, 12]. In addition, evidence from in vitro studies suggest that among the anti-inflammatory actions of steroids there are a reduction in the generation of reactive oxygen species by neutrophils [24]and stimulation of the synthesis of glutathione in liver [25]. A few in vivo studies showed antioxidant effects of steroids.…”

Section: Discussionmentioning

confidence: 99%

Effects of Inhaled Corticosteroids with Different Lung Deposition on Exhaled Hydrogen Peroxide in Stable COPD Patients

Beurden

Harff²,

Dekhuijzen³

et al. 2003

Respiration

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Background: The effects of inhaled corticosteroids (ICS) on markers of oxidative stress in patients with stable COPD are unclear. Objectives: The aim was to investigate the effect of ICS on exhaled H₂O₂ in stable COPD patients and to compare ICS with different lung deposition. Methods: Forty-one stable patients with moderate COPD (FEV₁ ∼60% predicted) were randomized to sequence 1; first HFA-134a beclomethasone dipropionate (HFA-BDP, an ICS with more peripheral deposition) 400 µg b.i.d., then fluticasone propionate (FP, an ICS with more central deposition) 375 µg b.i.d. (n = 20) or sequence 2 ; first FP, then HFA-BDP (n = 21). Both 4-week treatment periods were preceded by a 4-week washout period. After each period, the concentration of H₂O₂ in exhaled breath condensate was measured. Results: The H₂O₂ concentration decreased significantly after the first treatment period in both sequence 1 and 2 (p < 0.05, p = 0.01, respectively). In neither sequence was there a return to baseline values after the second washout, indicating a carry-over effect. The concentrations remained low in both sequences during the second treatment period. Conclusions: Both ICS appeared to reduce exhaled H₂O₂ in stable COPD patients. However, this study showed no difference between ICS with different deposition patterns, which in part may be due to the carry-over effect.

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“…Another explanation for the observed decrease of total glutathione in the present study may be that GSSG is transported out of the RBC; however, this mechanism mainly occurs in heart and liver cells [9] and is only observed in RBC when exposed to very high levels of ROS. In addition, the observation of a decrease in RBC glutathione indirectly argues against systemic effects of inhaled BDP, since systemically applied corticosteroids have been shown in mice to increase hepatic synthesis of glutathione [40].…”

Section: Discussionmentioning

confidence: 99%

CD69 surface expression on human lung eosinophils after segmental allergen provocation

Julius¹,

Luttmann²,

Knoechel³

et al. 1999

Eur Respir J

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In asthmatic patients, antioxidant defence is decreased. Although inhaled corticosteroids decrease asthmatic inflammation and modulate reactive oxygen species (ROS) generation, little is known of their effect on cellular antioxidant levels. The aim of this study was to evaluate the effect of inhaled beclomethasone dipropionate (BDP; 1,000 mg . day -1 ) on erythrocyte antioxidant levels in stable asthmatic patients.Forty patients with stable, mild asthma were treated in a double-blind, placebocontrolled, parallel-group study with BDP 250 mg, two puffs b.i.d. for 6 weeks. At entry and every 2 weeks during treatment, erythrocyte antioxidant levels, haematological parameters, pulmonary function tests and asthma symptoms were determined.The results show that during treatment with BDP, erythrocyte catalase levels increased (at entry (meanSEM) 414, after 6 weeks 544 mmol H 2 O 2 . min -1 . g haemoglobin (Hb) -1 , p=0.05 in comparison with placebo). Erythrocyte total glutathione levels significantly decreased after 6 weeks treatment with BDP (from 7.00.4 to 6.60.3 mmol . g Hb -1 (p=0.04)). In the BDP-treated patients, blood eosinophil counts were higher in patients who responded with an increase in erythrocyte catalase levels during BDP treatment, as compared to those not responding ((meanSEM) 34039 and 15352610 6 cells . L -1, respectively, p=0.05). The present study shows that treatment with inhaled bedomethasone dipropionate results in changes in antioxidant levels in erythrocytes of patients with stable, mild asthma. Eur Respir J 1999; 13: 1260±1266.

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Prednisolone stimulates hepatic glutathione synthesis in mice

Cited by 18 publications

References 19 publications

Attenuation of oxidant/antioxidant imbalance during treatment of exacerbations of chronic obstructive pulmonary disease

Attenuation of oxidant/antioxidant imbalance during treatment of exacerbations of chronic obstructive pulmonary disease

Effects of Inhaled Corticosteroids with Different Lung Deposition on Exhaled Hydrogen Peroxide in Stable COPD Patients

CD69 surface expression on human lung eosinophils after segmental allergen provocation

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