Prednisolone Induced Cushing Syndrome: A Case Report

Paul, Eldho; Jose, Stimson; Achar, Yogananda; Raghunath, Bharathi Doddlu

doi:10.5530/ijopp.9.2.15

Cited by 4 publications

(3 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Exogenous use of glucocorticoids (GCs), which are often administered in a regulated medical environment but their fraudulent use is uncommon, is the most frequent cause. Females, young patients, those with psychiatric illnesses, and those with connections in the medical industry are more likely to experience factitious CS [4].…”

Section: Discussionmentioning

confidence: 99%

Dexamethasone Induced Cushing's syndrome: A Case Report

Zaveri¹,

Thakkar²,

Solanki³

et al. 2022

Glob Acad J Pharm Drug Res

View full text Add to dashboard Cite

The term Cushing syndrome refers as the manifestations of excessive corticosteroids, most commonly due to supra physiologic doses of corticosteroids drugs and rarely due to spontaneous production of excessive corticosteroids by the adrenal cortex. In this case a 22 year old male patient came to the tertiary care hospital with the complaint of skin lesions over the body over three months. Patient taking injection of dexamethasone from the last 8 months, taking 2 doses within 15 days. On examination multiple erythematous, dry scaly plaques seen, multiple striae seen over bilateral crural folds, facial puffiness since eight months, abdominal distension. The patient was diagnosed with iatrogenic cushing's syndrome with tinea cruris with tinea corporis with acne eruption and also newly detected hypertension. Early detection of adverse effects can reduce the risk of occurrence of any other disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Dexamethasone Induced Cushing's syndrome: A Case Report

Zaveri¹,

Thakkar²,

Solanki³

et al. 2022

Glob Acad J Pharm Drug Res

View full text Add to dashboard Cite

show abstract

“…Fetotoxicity because its metabolite can pass into breastmilk Adulteration with mefenamic acid McKillop and Canning (1987) and Kamour et al 2017) Central nervous system toxicity, especially convulsions, altered conscious level, agitation, aggression, confusion, or disorientation Baker et al (1984) Interstitial nephritis and renal failure Adulteration with prednisone Ton et al (2004) and Lim and Pranata (2020) Steroid-dependence which can cause an acutely life-threatening condition in a sudden cessation White (2019) Adrenal crisis, resulting in vomiting, diarrhoea, flu-like illness, infective gastro-enteritis, and even death Paul et al (2016) Bone loss, osteoporosis, Cushing syndrome, cataract, hypertension, dyslipidaemia, skin atrophy, failure to thrive, hypo-thalamo-pituitary-adrenal axis suppression, striae, glaucoma, and a predisposition to life-threatening infections Adulteration with sibutramine hydrochloride James et al (2000) and de Simone and D'Addeo (2008) Increase of systemic pressure and heart rate, which are symptoms associated with cardiovascular effects Chong (2010) Psychosis Adulteration with sildenafil citrate McMurray (2007) Headache, dyspepsia, rhinitis, flushing, abnormal vision, and dizziness Nissan et al (2016) Acute liver toxicity Kloner (2007), Boden et al (2012), andEMA (2016) A risk for people using antihypertensives such as nitrates (e.g. nitroglycerine, doxazosin, and terazosin) and patients suffering from hypotension for whom use of PDE-5 inhibitors is contra-indicated Adulteration with glibenclamide EMA (2018b)…”

Section: Referencesmentioning

confidence: 99%

Risk characterisation of constituents present in jamu to promote its safe use

Suparmi

Wahidin²,

Rietjens

2021

Critical Reviews in Toxicology

View full text Add to dashboard Cite

Safety in use of jamu consumption, as part of traditional medicine from Indonesia, is dependent on the complete and adequate assessment of potential hazards and risks of the botanicals and botanical constituents included. This includes especially hazards and risks related to the presence in jamu of active pharmaceutical ingredients (APIs) as well as of constituents that are genotoxic and carcinogenic. The present review presents an overview of the current state-of-the art on these hazards and risks based on case reports on adulteration, and the actual detection of genotoxic and carcinogenic ingredients of concern in jamu. Based on the overview thus obtained, it appears that drug-adulteration presents important hazards responsible for potential adverse effects, due to overdosing. The potential hazards of exposure to APIs mainly relate to the presence of constituents that may cause liver damage, renal impairment, kidney failure, steroid dependence or genotoxicity and carcinogenicity. For these APIs, a risk characterisation was performed based on comparison of health-based guidance values (HBGVs) and exposure, while for the genotoxic carcinogens the margin of exposure (MOE) approach was used. Results of this risk characterisation should be used by risk managers to impose specification for constituents of health concern to protect consumers. It is concluded that to manage the risks identified and further improve the safety in use of jamu, a collaboration between farmers, manufacturer/producers, academia, government, health professionals, and consumers is indicated.

show abstract

“…Ilgalaikis gliukokortikoidų vartojimas taip pat turėjo įtakos antrinės arterinės hipertenzijos atsiradimui (10), aukštas pacientės kraujospūdis laikėsi net ir antihipertenzinių vaistų vartojimo pradžioje. Imuniteto slopinimas yra dar viena nepageidaujama reakcija sukelta piktnaudžiaujant prednizolonu ir gali lemti gyvybei pavojingų infekcijų atsiradimą (11). Stacionare nutraukiamas gliukokortikoidų vartojimas, tačiau pacientė išliko nekritiška ir nebuvo motyvuota nutraukti prednizolono vartojimo.…”

Section: Diskusijaunclassified

Kušingo Sindromas, Išsivystęs Dėl Piktnaudžiavimo Prednizolonu: Klinikinis Atvejis

Budrytė¹,

Karnickas²

2019

Public Health

View full text Add to dashboard Cite

Somatiniai simptomai, kurių priežasties neįmanoma paaiškinti jokia organine patologija atliekant diagnostinius tyrimus, yra vienas pagrindinių somatoforminių sutrikimų požymių. Nors somatinių simptomų paplitimas pirminėje sveikatos priežiūros srityje siekia iki 49 %, somatoforminiai sutrikimai retai diagnozuojami klinikinėje praktikoje ir diagnostiniais kriterijais persidengia su funkciniais sutrikimais. Šiame straipsnyje aptariamas klinikinis atvejis, kuriame atsiskleidžia sudėtinga ir užsitęsusi somatoforminių sutrikimų eiga, sukėlusi sunkias pasekmes pacientei. Besikartojančios įvairių specialistų konsultacijos ir tyrimai, gydytojų nesusitarimas ir kelių skirtingų diagnozių nustatymas lemia pacientės nepasitikėjimą paskirtu gydymu ir nesuteikiama tinkama pagalba. Tai sukėlė ne tik suprastėjusią pacientės gyvenimo kokybę, bet ir sunkų piktnaudžiavimą gliukokortikoidais, Kušingo sindromo išsivystymą ir antrinių lėtinių ligų atsiradimą. Taip pat pristatoma nauja pasiūlyta diagnostinė kategorija, kuri galėtų sujungti somatoforminius sutrikimus ir funkcinius somatinius sindromus. Tikimasi, jog tai užtikrins efektyvesnį somatoforminių sutrikimų eigos valdymą ir gydymą.

show abstract

Prednisolone Induced Cushing Syndrome: A Case Report

Cited by 4 publications

References 1 publication

Dexamethasone Induced Cushing's syndrome: A Case Report

Dexamethasone Induced Cushing's syndrome: A Case Report

Risk characterisation of constituents present in jamu to promote its safe use

Kušingo Sindromas, Išsivystęs Dėl Piktnaudžiavimo Prednizolonu: Klinikinis Atvejis

Contact Info

Product

Resources

About