Prednisolone excretion in human milk

L, Ost; Wettrell, Göran; Björkhem, Ingemar; Rane, Anders

doi:10.1016/s0022-3476(85)80259-6

Cited by 206 publications

(12 citation statements)

References 5 publications

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“…Although the metabolite is relatively inactive, it is advisable to avoid administering a high dose of 5-ASA to lactating women. Use of corticosteroids results in low concentrations of drug in breastmilk, and a 4-hour delay following oral dosing is recommended to reduce neonatal exposure 193. Infant exposure to AZA metabolites through breastmilk is undetectable 194.…”

Section: Special Populationsmentioning

confidence: 99%

Management of Crohn's disease in Taiwan: consensus guideline of the Taiwan Society of Inflammatory Bowel Disease

et al. 2017

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Crohn's disease (CD) is a chronic relapsing and remitting inflammatory disease of the gastrointestinal tract. CD is rare in Taiwan and other Asian countries, but its prevalence and incidence have been steadily increasing. A steering committee was established by the Taiwan Society of Inflammatory Bowel Disease to formulate statements on the diagnosis and management of CD taking into account currently available evidence and the expert opinion of the committee. Thorough clinical, endoscopic, and histological assessments are required for accurate diagnosis of CD. Computed tomography and magnetic resonance imaging are complementary to endoscopic evaluation for disease staging and detecting complications. The goals of CD management are to induce and maintain remission, reduce the risk of complications, and improve quality of life. Corticosteroids are the mainstay for inducing re-mission. Immunomodulating and biologic therapies should be used to maintain remission. Patients should be evaluated for hepatitis B virus and tuberculosis infection prior to treatment and receive regular surveillance for cancer. These consensus statements are based on current local evidence with consideration of factors, and could be serve as concise and practical guidelines for supporting clinicians in the management of patients with CD in Taiwan.

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Section: Special Populationsmentioning

confidence: 99%

Management of Crohn's disease in Taiwan: consensus guideline of the Taiwan Society of Inflammatory Bowel Disease

et al. 2017

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“…A nursing infant of a mother consuming a daily dose of 80 mg of prednisolone would ingest < 0.1%, which is equivalent to < 10% of endogenous cortisol production [249]. As a result, although it may be reasonable to delay breast-feeding for several hours after ingesting prednisone, it appears to be safe during breast-feeding [251]. …”

Section: Urticaria and Pregnancymentioning

confidence: 99%

Diagnosis and Treatment of Urticaria and Angioedema: A Worldwide Perspective

Sánchez‐Borges

Asero

Ansotegui³

et al. 2012

World Allergy Organization Journal

180

111

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Urticaria and angioedema are common clinical conditions representing a major concern for physicians and patients alike. The World Allergy Organization (WAO), recognizing the importance of these diseases, has contributed to previous guidelines for the diagnosis and management of urticaria. The Scientific and Clinical Issues Council of WAO proposed the development of this global Position Paper to further enhance the clinical management of these disorders through the participation of renowned experts from all WAO regions of the world. Sections on definition and classification, prevalence, etiology and pathogenesis, diagnosis, treatment, and prognosis are based on the best scientific evidence presently available. Additional sections devoted to urticaria and angioedema in children and pregnant women, quality of life and patient-reported outcomes, and physical urticarias have been incorporated into this document. It is expected that this article will supplement recent international guidelines with the contribution of an expert panel designated by the WAO, increasing awareness of the importance of urticaria and angioedema in medical practice and will become a useful source of information for optimum patient management worldwide.

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“…Only trace amounts of hydrocortisone are excreted into human breast milk [ 84 ]. In six lactating women, prednisolone doses of 10 to 80 mg/day resulted in milk concentrations ranging from 5% to 25% of maternal serum levels [ 85 ]. Even at a maternal dose of 80 mg/day, the nursing infant would ingest only 10 μg/kg which corresponds to <10% of the infant's endogenous cortisol production.…”

Section: Corticosteroidsmentioning

confidence: 99%

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et al. 2006

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Rheumatic diseases in women of childbearing years may necessitate drug treatment during a pregnancy, to control maternal disease activity and to ensure a successful pregnancy outcome. This survey is based on a consensus workshop of international experts discussing effects of anti-inflammatory, immunosuppressive and biological drugs during pregnancy and lactation. In addition, effects of these drugs on male and female fertility and possible long-term effects on infants exposed to drugs antenatally are discussed where data were available. Recommendations for drug treatment during pregnancy and lactation are given. Review Anti-inflammatory and immunosuppressive drugs and reproduction

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Prednisolone excretion in human milk

Cited by 206 publications

References 5 publications

Management of Crohn's disease in Taiwan: consensus guideline of the Taiwan Society of Inflammatory Bowel Disease

Management of Crohn's disease in Taiwan: consensus guideline of the Taiwan Society of Inflammatory Bowel Disease

Diagnosis and Treatment of Urticaria and Angioedema: A Worldwide Perspective

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