Predisposing factors and incidence of newly diagnosed atrial fibrillation in an urban African community: insights from the Heart of Soweto Study

Sliwa, Karen; Carrington, Melinda; Klug, Eric; Opie, Lionel H.; Lee, Geraldine; Ball, Jocasta; Stewart, Simon

doi:10.1136/hrt.2010.206938

Cited by 61 publications

(110 citation statements)

References 29 publications

(36 reference statements)

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“…Although the prevalence of diagnosed type 2 diabetes was relatively low (3.4%), 7% of patients (mainly obese women) were at risk of metabolic disorders on the basis of their blood glucose profile. Significantly, obesity is associated with other rarely reported forms of CVD in Soweto, with obese women in the Heart of Soweto cohort being more likely to present with atrial fibrillation [16]. Therefore, the potential impact of enhanced primary prevention in this context is obvious, particularly in truncating a future rise in hypertensive heart disease [17,18] as life-expectancy and unhealthy lifestyles escalate.…”

Section: Discussionmentioning

confidence: 99%

Elevated risk factors but low burden of heart disease in urban African primary care patients: A fundamental role for primary prevention

Stewart

Carrington

Pretorius

et al. 2012

International Journal of Cardiology

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Section: Discussionmentioning

confidence: 99%

Elevated risk factors but low burden of heart disease in urban African primary care patients: A fundamental role for primary prevention

Stewart

Carrington

Pretorius

et al. 2012

International Journal of Cardiology

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“…In South Africa (SA), the prevalence of AF in the urban black population has recently been documented to be 7% in a cardiovascular disease cohort (8% of heart failure patients, 4% of hypertensive patients, and 13% of valvular disease patients). [13] However, very little has been published on AF management outside the deve loped world. This prompted the Assessment of the Therapeutic Management of Patients with Atrial Fibrillation in South Africa (SAFIR-RSA).…”

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confidence: 99%

A survey on the treatment of atrial fibrillation in South Africa

Jardine¹,

Obel

2014

S Afr Med J

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Background. The burden of cardiovascular disease is expected to escalate in developing countries. However, studies and guidelines concerning atrial fibrillation (AF) are restricted to the developed world. Objectives. To assess the treatment modalities of AF in South Africa. Methods. A cross-sectional, observational, multicentre, national registry of the treatment of 302 patients with AF was conducted from February 2010 to March 2011. Specific drug use for rate or rhythm control, as well as drug use for stroke prevention, was surveyed. Events during the 12 months prior to the survey were also characterised, including non-drug treatments, resource utilisation and complications. Results. The single most prevalent clinical characteristic was hypertension (65.9%). Rhythm control was being pursued in 109 patients (36.1%) with class Ic and class III antiarrhythmic agents, while rate control, mainly with beta-blockers, was pursued in the remainder of the patients. Concomitant use of other cardiovascular drugs was high, and 75.2% of patients were on warfarin for stroke prevention. There was a high burden of AF-related morbidity during the preceding year, with 32.5% reporting a history of heart failure, 8.3% a stroke and 5.3% a transient ischaemic attack. Therapeutic success, as defined by either the presence of sinus rhythm or rate-controlled AF, was achieved in 86.8% as judged clinically by the treating physician, but in only 70.2% according to the electrocardiogram criterion of heart rate ≤80 bpm. Conclusion. There were no striking differences from previously reported registries worldwide. The lack of application of strict rate control criteria is highlighted.

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“…Several studies have shown that this rhythm disorder is associated with higher risk of readmission in individuals with HF regardless of ejection fraction or rhythm control. 29,30 Recent findings from Africa suggest that AF occurs in 4.6% of cardiac cases (estimated 5.6 out of 100,000 cases/y) 31 The mean age of occurrence is 57.2 6 18.8 years in Africa compared with 70.1 6 13.4 years in North America. 32 Common risk factors include hypertension, HF, and valvular heart disease.…”

Section: Discussionmentioning

confidence: 96%

Predictors of Rehospitalization in Patients Admitted With Heart Failure in Abeokuta, Nigeria: Data From the Abeokuta Heart Failure Registry

Stewart

Falase

Akinyemi

et al. 2014

Journal of Cardiac Failure

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Predisposing factors and incidence of newly diagnosed atrial fibrillation in an urban African community: insights from the Heart of Soweto Study

Abstract: These unique data suggest that urban Africans in Soweto develop AF at a relatively young age. Conventional strategies used to manage and treat AF need to be carefully evaluated in this setting.

Cited by 61 publications

References 29 publications

Elevated risk factors but low burden of heart disease in urban African primary care patients: A fundamental role for primary prevention

Elevated risk factors but low burden of heart disease in urban African primary care patients: A fundamental role for primary prevention

A survey on the treatment of atrial fibrillation in South Africa

Predictors of Rehospitalization in Patients Admitted With Heart Failure in Abeokuta, Nigeria: Data From the Abeokuta Heart Failure Registry

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