1967
DOI: 10.1016/s0022-3476(67)80052-0
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Predinsome therapy of acute childhood leukemia: Prognosis and duration of response in 330 treated patients

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1968
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Cited by 64 publications
(8 citation statements)
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“…3 In a study of 271 murine lymphoid cell lines the glucocorticoid receptor was shown to be the primary target for development of glucocorticoid resistance. 4 Resistance to glucocorticoids is significantly increased in childhood ALL patients at relapse compared to diagnosis.…”
Section: Introductionmentioning
confidence: 99%
“…3 In a study of 271 murine lymphoid cell lines the glucocorticoid receptor was shown to be the primary target for development of glucocorticoid resistance. 4 Resistance to glucocorticoids is significantly increased in childhood ALL patients at relapse compared to diagnosis.…”
Section: Introductionmentioning
confidence: 99%
“…The ability of glucocorticoid hormones to induce apoptosis in leukemia and lymphoma cells has been utilized by physicians for nearly a half-century (1,2). Today glucocorticoids are common components in many chemotherapeutic protocols for lymphoid malignancies, including multiple myeloma, acute lymphoblastic leukemia, chronic lymphocytic leukemia, and non-Hodgkin's lymphoma (3)(4)(5)(6).…”
mentioning
confidence: 99%
“…Most of the reported cases recovered spontaneously from the aplastic phase; prompt response to predni sone has also been described [1][2][3][4][5][6][7][8]. It is not clear whether the aplastic phase represents a true marrow failure preceding the development of ALL or the re mission of undiagnosed ALL.…”
Section: Discussionmentioning
confidence: 99%
“…In children typical aplastic anemia (AA) may pre cede the onset of acute lymphoblastic leukemia (ALL); the aplastic phase is transient and remission may be spontaneous or rapidly induced by corticoste roids [1][2][3][4][5][6][7][8]. This modality of presentation is observed in about 2-3% of pediatric ALL cases [8].…”
Section: Introductionmentioning
confidence: 99%