Predictors of Weight Change in Male HIV-Positive Injection Drug Users Initiating Antiretroviral Therapy in Hanoi, Vietnam

Tang, Alice; Sheehan, Heidi; Jordan, Michael R.; Duong, Dang Van; Terrin, Norma; Dong, Kimberly R.; Lien, Trinh Thi Minh; Trung, Nguyen Vu; Wanke, Christine; Hiền, Nguyễn Đức

doi:10.1155/2011/890308

Cited by 15 publications

(15 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It was found that several significant predictors of weight gain, particularly in the first six months after ART initiation. Patients with more advanced HIV infection at baseline (CD 4 cell counts <200 cells/μl) were more likely to have positive weight changes (54 to 61 kg) in the first six months of therapy than the other, likely due to the beneficial effects of ART, which is similar to the above study 32 , while patients receiving ART whose CD 4 cell count > 350 cells/ µl patient had the least weight improvement from 56 kg to 59 kg this may due to they had good immune system. The average weight gain over the 24 months was 6 kg this is higher when compared with study conducted by Ross-Degnan et al and BMC Health services research both research stated that patients gained an average of 3.9 kg in the first six months of treatment 22 .…”

Section: Discussionsupporting

confidence: 70%

Assessment of Antiretroviral Therapy (Art) Outcomes Versus Cd4 Cell Count Threshold Among Hiv/Aids Patients in Ras Desta Hospital, Addis Ababa, Ethiopia

Kahissay¹,

Oga²,

Pharmacist³

2015

J Pharm Sci Innov

View full text Add to dashboard Cite

The initiation of ART is best based on CD4 cell count, a marker of immune status, rather than on viral load, a marker of virologic replication. For patients with advanced symptoms, treatment should be started regardless of CD4 count. However, the point during the course of HIV infection at which antiretroviral therapy (ART) is best initiated in asymptomatic patients remains unclear. The objective of this study is to assess ART treatment outcomes verses CD4 count threshold among HIV/AIDS patients in Ras Desta hospital. This was a periodic retrospective cross sectional study of HIV positive patient's ART treatment outcomes in relation to CD4 count threshold in Ras Desta hospital. From all HIV positive patients who had registered for ART from September 2009-February 2011 at Ras Desta hospital, 636 patients had met the criteria of the study and they were selected. Out of the 636 patients chosen for the study, 372 (58.5 %) were females while 264 (41.5 %) were males. For the whole sample under study, the median age was 36 years. Out of 636 patients 504 patients had a CD4 count less than 200 cells /mm 3 , 120 had a CD4 count greater than 200 and less than 350 cells/µl. Lastly, a total of 12 patients had a CD4 count greater than 350 cells /mm 3 at the initiation of ART. Other findings show that for all patients in the study receiving ART, median weight was 53 Kg (range 27 kg to 93 kg). Four hundred eighty (75.5 %) patients were alive, twenty one (3.3 %) patients had transferred out, 67 (10.5 %) were lost to follow-up and 68 (10.7 %) had died during two year period of ART use. A further observations of the deaths revealed that 53 (78 %) were CD4 count less than 200 cells/µl, 14 (20.5 %) patients were CD4 count > 200 and < 350 cells/µl, while only 1 (1.5 %) of the patient were died whose CD4 count > 350 cells/µl. This study show that early initiation of ART at CD4 levels higher than 200 cells/µl reduces mortality, immune-depression and weight loss and also improve outcome of ART treatment in asymptomatic, ART-naive, HIV-infected people. Practitioners and policy-makers may consider initiating ART at levels > 200 cells/ µl.

show abstract

Section: Discussionsupporting

confidence: 70%

Assessment of Antiretroviral Therapy (Art) Outcomes Versus Cd4 Cell Count Threshold Among Hiv/Aids Patients in Ras Desta Hospital, Addis Ababa, Ethiopia

Kahissay¹,

Oga²,

Pharmacist³

2015

J Pharm Sci Innov

View full text Add to dashboard Cite

show abstract

“…among adult receiving ART in Vietnam (Table 4). The proportion of viral suppression (< 1,000 copies/ml) at 6 and 12 month since ART initiation among IDU who were recruited from a treatment site in Ha Noi in 2006-2008, was of 74% and 68%, respectively [42]. This figure was likely to be substantially lower than of that of an average people receiving ART.…”

Section: Risks Factors For Emergence and Transmission Of Hiv Drug Resmentioning

confidence: 88%

“…Non-adherence is caused by numerous factors. Most adults on ART were IDU (62%) [24], whose high level of active illicit drug use during therapy (30-33%) [42], directly impacts on their adherence to ARV drugs. Furthermore, widespread stigma and discrimination related to HIV infection leads to a fear of disclosure of their HIV positive status and use of ART [54].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies investigated adherence among adults (aged over 18 years) receiving ART in Vietnam and showed that around one quarter of adults surveyed had poor adherence to HIV medications in the preceding month. During 2006-2008 in Ha Noi, this rate among 100 HIV-acquired IDU after 6 and 12 month of initiation of ART was of 26% and 32%, respectively, based on a 30-day visual analogue scale [42]. Although with different the study site, time and methodology, two other cross-sectional, clinic-based surveys in 2009-2010 also demonstrated a similar percentage of 25% self-reporting as nonadherence [43,44] (Table 4).…”

Section: Risks Factors For Emergence and Transmission Of Hiv Drug Resmentioning

confidence: 99%

See 1 more Smart Citation

A Review of the Extent of HIV Drug Resistance in Vietnam

2013

View full text Add to dashboard Cite

Background: In 2005, free antiretroviral therapy (ART) was rolled-out as a national program in Viet Nam. The estimated population of people living with HIV reached 254,000 in 2010 and this leads to increasing demand of ART in the near future. By 2009, ART coverage reached 53.7% for adults and adolescents, and 49.7% for children. This study aims to describe the prevalence of HIV acquired drug resistance (ADR) among people receiving ART and prevalence of transmitted drug resistance (TDR) among recently HIV-infected persons in Vietnam, and their associated ART coverage, antiretroviral treatment adherence and risk behaviors. Methods: We performed a comprehensive review of published English literature containing relevant epidemiological and behavioral indicators through internet searches. Results: Twenty-one relevant publications were included in this review. TDR prevalence among people recently infected with HIV increased from below 5% in 2006 to a higher level of 5-15% during 2007-2008 in urban Vietnam, whereas TDR prevalence among chronic antiretroviral-naïve HIV-infected adults stabilized between 6-8% across the country. About half of all adults and children with clinical or immunological criteria of therapeutic failure had evidence of developing resistance to antiretroviral drugs. Non-adherence among adults on ART ranged between 25-32% and the level of viral suppression (< 1,000 copies/ml) fluctuated from 68% to more than 83% at 12 month after initiating ART. However, relevant data concerning children were mostly absent. Conclusion: Increasing trend of transmission of HIV drug resistance was observed in urban Vietnam, suggesting an urgency of the establishment of regular surveillance for TDR. Viral load testing and availability of second or third line ART are recommended for the early diagnosis of drug resistance and prevention of its accumulation and transmission.

show abstract

“…The HFIAS has been used in several HIV cohorts in the US [47,48], and among HIV-positive populations in Zambia, Uganda and Kenya [49][50][51]. The Household Food Security Scale-Short Form (HFSS-SF) was recently applied in cohorts of PLHIV in Tanzania [52] and Vietnam [53].…”

Section: Food and Nutrition Scurity Measuresmentioning

confidence: 99%

Measuring Food and Nutrition Security: Tools and Considerations for Use Among People Living with HIV

et al. 2013

View full text Add to dashboard Cite

As an increasing number of countries implement integrated food and nutrition security (FNS) and HIV programs, global stakeholders need clarity on how to best measure FNS at the individual and household level. This paper reviews prominent FNS measurement tools, and describes considerations for interpretation in the context of HIV. There exist a range of FNS measurement tools and many have been adapted for use in HIV-endemic settings. Considerations in selecting appropriate tools include subtypes (food sufficiency, dietary diversity and food safety); scope/level of application; and available resources. Tools need to reflect both the needs of PLHIV and affected households and FNS program objectives. Generalized food sufficiency and dietary diversity tools may provide adequate measures of FNS in PLHIV for programmatic applications. Food consumption measurement tools provide further data for clinical or research applications. Measurement of food safety is an important, but underdeveloped aspect of assessment, especially for PLHIV.

show abstract

Predictors of Weight Change in Male HIV-Positive Injection Drug Users Initiating Antiretroviral Therapy in Hanoi, Vietnam

Cited by 15 publications

References 19 publications

Assessment of Antiretroviral Therapy (Art) Outcomes Versus Cd4 Cell Count Threshold Among Hiv/Aids Patients in Ras Desta Hospital, Addis Ababa, Ethiopia

Assessment of Antiretroviral Therapy (Art) Outcomes Versus Cd4 Cell Count Threshold Among Hiv/Aids Patients in Ras Desta Hospital, Addis Ababa, Ethiopia

A Review of the Extent of HIV Drug Resistance in Vietnam

Measuring Food and Nutrition Security: Tools and Considerations for Use Among People Living with HIV

Contact Info

Product

Resources

About