Predictors of urinary phthalate biomarker concentrations in postmenopausal women

Reeves, Katherine W.; Santana, Mary Díaz; Manson, Jo Ann E.; Hankinson, Susan E.; Zoeller, R. Thomas; Bigelow, Carol; Hou, Lifang; Wactawski‐Wende, Jean; Liu, Simin; Tinker, Lesley F.; Calafat, Antònia M.

doi:10.1016/j.envres.2018.10.024

Cited by 22 publications

(10 citation statements)

References 47 publications

(57 reference statements)

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“…We found that urinary concentrations of the low molecular weight phthalate metabolites MEP and MBP were positively associated with BMI, which is consistent with some 40 , 59 – 61 but not all 62 previous studies. We also observed higher concentrations of metabolites of high molecular weight phthalates (including DINP and DEHP) among women with higher BMI.…”

Section: Discussionsupporting

confidence: 92%

Correlates of urinary concentrations of phthalate and phthalate alternative metabolites among reproductive-aged Black women from Detroit, Michigan

Wesselink

Fruh

Hauser

et al. 2020

J Expo Sci Environ Epidemiol

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Background: Phthalates are endocrine-disrupting chemicals that are widely present in consumer products. In the United States, Black women are more highly exposed to phthalates than other racial/ethnic groups, yet information on predictors of phthalate exposure among Black women is limited. Objective: We evaluated the association of demographics, lifestyle, reproductive history, and personal care product use with urinary concentrations of phthalate and phthalate alternative metabolites, using cross-sectional data from 754 Black women from Detroit, Michigan (2010–2012). Methods: Women completed questionnaires and provided urine specimens which were analyzed for 16 phthalate and phthalate alternative metabolites. We used linear regression models to estimate mean percentage differences and 95% confidence intervals (CIs) in concentrations across levels of correlates. Results: Monoethyl (MEP) and mono-n-butyl phthalate concentrations were positively associated with personal care product use, particularly nail products. Educational attainment was positively associated with high molecular weight phthalate concentrations but inversely associated with monobenzyl phthalate (MBzP) concentrations. Parity was positively associated with MBzP concentrations and inversely associated with concentrations of MEP and high molecular weight phthalates. Significance: We found that sociodemographics, reproductive characteristics, and use of certain personal care products were associated with urinary phthalate concentrations among Black women. Our results emphasize the importance of examining exposure determinants among multiply-marginalized populations.

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Section: Discussionsupporting

confidence: 92%

Correlates of urinary concentrations of phthalate and phthalate alternative metabolites among reproductive-aged Black women from Detroit, Michigan

Wesselink

Fruh

Hauser

et al. 2020

J Expo Sci Environ Epidemiol

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“…This could be due to the rapid biotransformation of parent compounds through metabolic processes (Staples et al., 1997), thereby preventing bioaccumulation. In humans, age‐related differences in phthalate exposure have been attributed to changes in metabolism and biotransformative properties that could potentially slow with age (Reeves et al., 2019). For example, children tend to excrete higher concentrations of oxidized DEHP metabolites (i.e., MEHHP and MEOHP) than MEHP compared to adults (Wittassek & Angerer, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…This large sample size enabled demographic examinations of phthalate exposure, a first for any marine mammal species. Conversely, human studies evaluating demographic differences may rely on sample sizes in the hundreds to thousands (CDC, 2019; Huang, Tsai, et al., 2015; Percy et al., 2016; Reeves et al., 2019). Second, this study relied upon well‐established CDC analytical methods to screen for phthalate metabolites in urine, a matrix that consistently yields accurate measurements, even at low concentrations (Calafat & McKee, 2006; Frederiksen et al., 2007).…”

Section: Discussionmentioning

confidence: 99%

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Demographic Assessment of Mono(2‐ethylhexyl) Phthalate (MEHP) and Monoethyl Phthalate (MEP) Concentrations in Common Bottlenose Dolphins (Tursiops truncatus) From Sarasota Bay, FL, USA

et al. 2021

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Phthalates are esters; a colorless, odorless chemical compound originating from phthalic acid. They are used as plasticizers, often in conjunction with polyvinyl chloride (PVC) to soften and extend the durability of plastic, or to enhance certain properties of cosmetics, nail polishes, fragrances, sunscreens, building materials, waxes, food packaging, inks, textiles with prints, deodorizers, insecticides, toothbrushes, and car parts (Table 1; NTP-CERHR, 2003, 2000Shelby, 2006). Phthalates are not chemically bound to the product being modified, and can therefore easily leach into the surrounding environment (Aurela et al., 1999;FDA, 2001).

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“…We think smoking here may be more likely to re ect an unhealthy lifestyle. For example, the Women's Health Initiative found that a lack of healthy behaviors such as not smoking, a high-quality diet, and moderate physical activity were predictors of urinary phthalate metabolites (Reeves et al, 2019). A Norwegian study also indicated that smoking, consuming food with plastic packaging and eating with hands were associated with higher levels of phthalate metabolites (Giovanoulis et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Exposure to Phthalates and Cardiovascular Diseases with type 2 Diabetes

Zhang¹,

Chen

Chen³

et al. 2021

Preprint

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Purpose Cardiovascular disease (CVD) results in more than half of the mortality and the majority of morbidity in patients with type 2 diabetes. We aim to evaluate the associations of urinary concentrations of phthalate metabolites with CVD in diabetic patients and explore whether CVD risk factors mediate or interact with these associations.Methods A total of 675 type 2 diabetic participants were enrolled from one community in Shanghai, China in 2018. CVD was defined as a self-reported diagnosis by a physician and included coronary heart disease, myocardial infarction or stroke; it was further reconfirmed in the records from the registration platform. Ten phthalate metabolites were measured in urine.Results Positive associations were found among the level of monoethyl phthalate and monoisobutyl phthalate and CVD (OR 1.138, 95% CI 1.032, 1.254; OR 1.369, 95% CI 1.049, 1.786, respectively). Monoisobutyl phthalate and monobenzyl phthalate were marginally and positively associated with carotid intima-media thickness and common carotid artery diameter, respectively. None of the CVD risk factors, including HOMA-IR, body mass index, lipid profile or blood pressure, significantly mediated the association between the metabolites and CVD. The conditional indirect effect on CVD was significantly stronger for current smoking and dyslipidemia for monoethyl phthalate and for no statin usage and men for monoisobutyl phthalate.Conclusion Phthalate exposure was positively associated with CVD in type 2 diabetes. Type 2 diabetic men who are currently smoking, have an uncontrolled lipid profile and are not using statins may be more susceptible to CVD when exposed to phthalates.

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Predictors of urinary phthalate biomarker concentrations in postmenopausal women

Abstract: Background-Phthalates are ubiquitous endocrine disrupting chemicals present in a wide variety of consumer products. However, the personal characteristics associated with phthalate exposure are unclear.

Cited by 22 publications

References 47 publications

Correlates of urinary concentrations of phthalate and phthalate alternative metabolites among reproductive-aged Black women from Detroit, Michigan

Correlates of urinary concentrations of phthalate and phthalate alternative metabolites among reproductive-aged Black women from Detroit, Michigan

Demographic Assessment of Mono(2‐ethylhexyl) Phthalate (MEHP) and Monoethyl Phthalate (MEP) Concentrations in Common Bottlenose Dolphins (Tursiops truncatus) From Sarasota Bay, FL, USA

Exposure to Phthalates and Cardiovascular Diseases with type 2 Diabetes

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