Predictors of urinary antibiotics in children of Shanghai and health risk assessment

Wang, Hexing; Tang, Chuanxi; Yang, Jiaqi; Wang, Na; Jiang, Feng; Xia, Qinghua; He, Gengsheng; Chen, Yue; Jiang, Qingwu

doi:10.1016/j.envint.2018.09.032

Cited by 48 publications

(23 citation statements)

References 48 publications

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“…In order to distinguish the influences of home diet and school canteen diet on urine iodine concentration (UIC), each participant provided morning urine samples on a Monday and a Thursday, and we used the method of inductively coupled plasma mass spectrometry (ICP-MS) to determine the UICs. Weighted daily urine iodine output was calculated as follows: (1) daily urine iodine output (μg) = MCr×1000×UIC÷UCr, ( 22 ) (MCr: daily urine creatinine output, mmol/day, MCr = EXP(0.0102×H-0.6854; H: body height, cm; UIC: urine iodine concentration, μg/L; UCr: urine creatinine content, μmol/L); and (2) weighted daily urine iodine output (μg) = 2/7× daily urine iodine output on Monday + 5/7 × daily urine iodine output on Thursday.…”

Section: Methodsmentioning

confidence: 99%

Thyroid Stimulating Hormone (TSH) Is Associated With General and Abdominal Obesity: A Cohort Study in School-Aged Girls During Puberty in East China

Wang

Dong²,

et al. 2020

Front. Endocrinol.

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Section: Methodsmentioning

confidence: 99%

Thyroid Stimulating Hormone (TSH) Is Associated With General and Abdominal Obesity: A Cohort Study in School-Aged Girls During Puberty in East China

Wang

Dong²,

et al. 2020

Front. Endocrinol.

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“…Testing participants' feces and/or urine for the presence of antibiotic residues and/or metabolites has the potential to be an objective marker of current drug consumption; recent studies of urinary antibiotic residues among children demonstrate a correlation with self-reported antibiotic use 119 . Testing environmental samples that are impacted by human feces and urine, such as sewage or latrine pits, may be another approach for objectively inferring antibiotic use among a population 116 .…”

Section: ) Quantify the Impacts Of Improved Water Quality And Safelymentioning

confidence: 99%

“…Testing environmental samples that are impacted by human feces and urine, such as sewage or latrine pits, may be another approach for objectively inferring antibiotic use among a population 116 . However, measuring antibiotics and/or their metabolites can be expensive, the technology required may not be available in some LMICs, and antibiotics that are less stable (e.g., β-lactams) may not be detectable using current methods 119 . For estimates of population-level antibiotic use based on environmental samples, the partitioning of antibiotic residues between solid and aqueous phases would also have to be accounted for and this parameter may be difficult to estimate 116 .…”

Section: ) Quantify the Impacts Of Improved Water Quality And Safelymentioning

confidence: 99%

Urban informal settlements as hotspots of antimicrobial resistance and the need to curb environmental transmission

et al. 2020

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Antimicrobial resistance is a growing public health challenge that is expected to disproportionately burden lower-and middle-income countries (LMICs) in the coming decades. Although the contributions of human and veterinary antibiotic misuse to this crisis are well-recognized, environmental transmission (via water, soil, or food contaminated with human and animal feces) has been given less attention as a global driver of antimicrobial resistance (AMR), especially in urban informal settlements in LMICs, commonly known as "shantytowns" or "slums." These settlements may be unique hotspots for environmental AMR transmission given: 1) the high density of humans, livestock, and vermin living in close proximity; 2) frequent antibiotic misuse; and 3) insufficient drinking water, drainage, and sanitation infrastructure. Here, we highlight the need for strategies to disrupt environmental AMR transmission in urban informal settlements. We propose that water and waste infrastructure improvements tailored to these settings should be evaluated for their effectiveness in limiting environmental AMR dissemination, lowering the community-level burden of antimicrobial-resistant infections, and preventing antibiotic misuse. We also suggest that additional research is directed towards developing economic and legal incentives for evaluating and implementing water and waste infrastructure in these settings. Given that almost 90% of urban population growth will occur in regions predicted to be most burdened by the AMR crisis, there is an urgent need to build effective, evidence-based policies that could influence massive investments in the built urban environment in LMICs over the next few decades. Urban informal settlements are densely populated residential areas characterized by insufficient access to improved water and sanitation services, households constructed of non-durable material, insufficient living area, insecure residential status, and high participation in the informal economy 1-3. Four of the five largest slums in the world are in Asian and African LMICs, and in some countries, over 50% of the urban population resides in these types of settlements (e.g., Bangladesh, Kenya, Ethiopia) 1. Population densities are difficult to measure in urban informal settlements but they are estimated to exceed 125,000 persons/square km in multiple major LMIC cities, including Hyderabad

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“…Children following plant-based diets might have a lower risk of developing obesity [25], are less exposed to veterinary antibiotics found in animal-derived foods [26], and show a more favorable anti-inflammatory adipokine profile [27].…”

Section: Vegan Diets During Pregnancy Lactation and Childhoodmentioning

confidence: 99%

Vegan Nutrition for Mothers and Children: Practical Tools for Healthcare Providers

Baroni¹,

et al. 2018

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As the number of subjects choosing vegan diets increases, healthcare providers must be prepared to give the best advice to vegan patients during all stages of life. A completely plant-based diet is suitable during pregnancy, lactation, infancy, and childhood, provided that it is well-planned. Balanced vegan diets meet energy requirements on a wide variety of plant foods and pay attention to some nutrients that may be critical, such as protein, fiber, omega-3 fatty acids, iron, zinc, iodine, calcium, vitamin D, and vitamin B12. This paper contains recommendations made by a panel of experts from the Scientific Society for Vegetarian Nutrition (SSNV) after examining the available literature concerning vegan diets during pregnancy, breastfeeding, infancy, and childhood. All healthcare professionals should follow an approach based on the available evidence in regard to the issue of vegan diets, as failing to do so may compromise the nutritional status of vegan patients in these delicate periods of life.

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Predictors of urinary antibiotics in children of Shanghai and health risk assessment

Cited by 48 publications

References 48 publications

Thyroid Stimulating Hormone (TSH) Is Associated With General and Abdominal Obesity: A Cohort Study in School-Aged Girls During Puberty in East China

Thyroid Stimulating Hormone (TSH) Is Associated With General and Abdominal Obesity: A Cohort Study in School-Aged Girls During Puberty in East China

Urban informal settlements as hotspots of antimicrobial resistance and the need to curb environmental transmission

Vegan Nutrition for Mothers and Children: Practical Tools for Healthcare Providers

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