2020
DOI: 10.1016/j.hpb.2019.08.013
|View full text |Cite
|
Sign up to set email alerts
|

Predictors of underlying pancreatic cancer in patients with acute pancreatitis: a Danish nationwide cohort study

Abstract: Background: To identify demographic characteristics, comorbidities, medical procedures, and prescription drug use that may act as predictors of underlying pancreatic cancer in acute pancreatitis.Methods: A cohort study of all patients admitted to Danish hospitals with incident acute pancreatitis during 1999-2015. The ability of age, sex, selected comorbidities, medical procedures, and prescription drug use to predict underlying pancreatic cancer in acute pancreatitis (i.e., pancreatic cancer diagnosed up to on… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3

Citation Types

5
16
1

Year Published

2020
2020
2022
2022

Publication Types

Select...
8
1

Relationship

1
8

Authors

Journals

citations
Cited by 23 publications
(26 citation statements)
references
References 35 publications
5
16
1
Order By: Relevance
“…Over the past few decades, multiple studies have shown that AP might be one of the earliest manifestations of PDAC [ 73 , 74 , 75 , 76 ]. In fact, about one percent of AP cases are caused by PDAC [ 9 , 77 ]. The reported prevalence of AP prior to pancreatic cancer ranges between 1.4% and 6%, and most cases of PDAC-induced AP follow a mild disease course [ 75 , 78 , 79 ].…”
Section: Pancreatitis As An Initial Symptom Of Pancreatic Cancermentioning
confidence: 99%
See 1 more Smart Citation
“…Over the past few decades, multiple studies have shown that AP might be one of the earliest manifestations of PDAC [ 73 , 74 , 75 , 76 ]. In fact, about one percent of AP cases are caused by PDAC [ 9 , 77 ]. The reported prevalence of AP prior to pancreatic cancer ranges between 1.4% and 6%, and most cases of PDAC-induced AP follow a mild disease course [ 75 , 78 , 79 ].…”
Section: Pancreatitis As An Initial Symptom Of Pancreatic Cancermentioning
confidence: 99%
“…Idiopathic pancreatitis was found to be a significant predictor in a large Danish cohort, with an adjusted hazard ratio of 2.52 (95% CI: 1.83–3.47) [ 7 ]. Other important risk factors that were described in the literature were age higher than 50 at diagnosis of AP, new-onset diabetes mellitus, and findings of CP at the time of AP diagnosis with alarm symptoms, including weight loss [ 77 , 80 ]. A Chinese study evaluating clinical predictors of underlying malignancy at the time of AP diagnosis found unexplained dilation of the main pancreatic to be highly suggestive of tumor presence (OR 417.83; 95% CI: 80.40–2171.42).…”
Section: Pancreatitis As An Initial Symptom Of Pancreatic Cancermentioning
confidence: 99%
“…This well-designed study found that a presumed idiopathic etiology appeared to be associated with the highest risk of PDAC [adjusted hazard ratio of 2.52 (95%CI: 1.83-3.47)]. This finding was supported by a recent cohort study, which found that biliary AP and a history of alcohol-related disease were predictors for no underlying PDAC[ 11 ]. In this study of 28231 patients with AP, 283 received the diagnosis PDAC during follow-up (overall risk 1.0%).…”
Section: Ap and Pancreatic Cancermentioning
confidence: 78%
“…
We read with great interest the recently published study on underlying pancreatic cancer (PC) in acute pancreatitis (AP). 1 Identifying underlying PC is important to reduce misdiagnosis. While, study design and statistical method could be improved a bit.First, excluding patients with chronic pancreatitis (CP) could make the study more accurate.
…”
mentioning
confidence: 99%