Predictors of Treatment Response in Pediatric Obsessive-Compulsive Disorder

Evidence-Based Treatments in Treatment-Naïve and Treatment-Resistant Pediatric Obsessive-Compulsive Disorder

“…Interestingly, family accommodation does not seem to be associated with the clinical outcome when CBT follows a more intensive family approach [29]. Moreover, tic disorders do not seem to be a predictor of poor outcome either [27,29,30].…”

“…In addition, up to 30 % show little or no improvement [9,20]. Factors have been found that can predict a poor outcome of CBT, such as higher initial OCD severity [27][28][29], more internalizing and externalizing symptoms/disorders [28][29][30], and family dysfunction or high family accommodation [27,28,31]. Interestingly, family accommodation does not seem to be associated with the clinical outcome when CBT follows a more intensive family approach [29].…”

“…In the most recent review [27] of predictors of SSRI response, comorbid tics and externalizing disorders were associated with a poorer outcome. However, there was little evidence that gender, age, or duration of OCD predicted treatment response.…”

Obsessive-Compulsive Disorders or Not: Differential Diagnosis of Repetitive Behaviors Among Individuals with Intellectual and Developmental Disorders

“…Longitudinal studies also suggest that nearly 50% of this group will develop full syndrome OCD in time. Those converters are characterized by an early age of onset, positive family history of OCD and additional comorbid anxiety disorders (Murphy et al 2003;Black et al, 2008;Ginsberg et al 2008). In behavioral terms OCD is a response to distress created by disturbing cognitions, images, urges (obsessions).…”

Optimal management of pediatric obsessive-compulsive disorder

“…44,69,70 Furthermore, family accommodation can serve as a treatment barrier, preventing the child from experiencing the natural habituation of anxiety and reinforcing obsessivecompulsive symptoms. 71,72 insight and motivation Children with poor insight and low motivation may not respond optimally to treatment due to limited symptom resistance and poor adherence to treatment recommendations (eg, taking medication, participating in CBT). 67,73 Poor insight is associated with more severe obsessive-compulsive symptoms, higher levels of internalizing behaviors, greater impairment in school, social, and family contexts, and poor treatment response to CBT and pharmacotherapy.…”