Predictors of spermatogenesis in radical orchiectomy specimen and potential implications for patients with testicular cancer

Fertility preservation in testicular cancer – predictors of spermatogenesis

“…With regards to other markers, Delouya et al and Shoshany et al found that raised tumour markers and more advanced tumour stage were negatively associated with presence of spermatogenesis, but neither of these results have been reproduced in our present study or other studies .…”

“…Recently, several other studies have also investigated spermatogenesis predictors. Our present overall rate of spermatogenesis (70%) is comparable to previous findings of 68% , 62% and 79% . These studies also found a statistically significant negative relationship between testicular tumour size and presence of spermatogenesis.…”

“…Our present results support Suzuki et al [21] who did not find age to be associated with the presence of spermatogenesis in a similar cohort size of 104 specimens. However, in a cohort of 145 patients, Shoshany et al [18] found on univariate analysis that older age was a negative predictor of spermatogenesis (P = 0.05). Our present results showed that men aged ≥50 years were Age (years) Fig.…”

“…Our present results support Suzuki et al who did not find age to be associated with the presence of spermatogenesis in a similar cohort size of 104 specimens. However, in a cohort of 145 patients, Shoshany et al found on univariate analysis that older age was a negative predictor of spermatogenesis ( P = 0.05). Our present results showed that men aged ≥50 years were much less likely to have spermatogenesis (45%) compared to men aged <50 years (75%), although these data were only based on 11 patients, and it is too small to draw any statistically significant conclusions; a larger cohort is required to strengthen this finding.…”

Çocuk ve yetişkinde onko-tese uygulamaları: 2019 güncelleme

“…[12] Özellikle 4 cm'den büyük seminomötöz ve non-seminmatöz germ hücreli tümörler spermatogenezde önemli azalma ile birliktedir. [13][14][15] Tümör ve infertilite arasındaki ilişki çeşitli mekanizmalar ile açıklanmaya çalışılmaktadır [13,16,17] : i) Tümör tarafından lokal olarak salınan β-hCG, α-fötoprotein, LDH gibi maddeler ile spermatogenezin etkilenmesi; ii) Tümörün neden olduğu anti-sperm antikorlar ile kan-testis bariyerinin hasarlanması; iii) Hormonal aktif tümörlerde hipotalomo-hipofizer aksın etkilenmesi; iv) Tümöre bağlı ateş nedeni ile spermatogenezin bozulması; Yapılan bazı çalışmalarda tümör marker düzeyi ile sperm sayısı arasında negatif korelasyon olduğuna ait veriler de vardır.…”