Predictors of solid extra-hepatic non-skin cancer in liver transplant recipients and analysis of survival: A long-term follow-up study

Gitto, Stefano; Magistri, Paolo; Marzi, Luca; Mannelli, Nicolò; Maria, Nicola De; Mega, Andrea; Vitale, Giovanni; Valente, Giovanna; Vizzutti, Francesco; Villa, Erica; Marra, Fabio; Andreoné, Pietro; Benedetto, Fabrizio Di; Falcini, Margherita; Catellani, Barbara; Guerrini, Gian Piero; Serra, Valentina; Sandro, Stefano Di; Ballarin, Roberto; Piai, G.; Schepis, Filippo; Margotti, Marzia; Cursaro, Carmela; Simone, Paolo De; Petruccelli, S; Carrai, P; Forte, Paolo; Campani, Claudia; Zoller, Heinz

doi:10.1016/j.aohep.2022.100683

Cited by 6 publications

(2 citation statements)

References 35 publications

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“…Solid-organ transplant recipients (SOTRs) are known to be particularly susceptible to the development of malignancies, with skin cancers accounting for 40% of the total SOT-associated neoplasms [ 1 , 2 , 3 , 4 ]. In particular, non-melanoma skin cancers (NMSCs) seem to occur very frequently in SOTRs, representing one of the most common post-transplant complications.…”

Section: Introductionmentioning

confidence: 99%

De Novo Skin Neoplasms in Liver-Transplanted Patients: Single-Center Prospective Evaluation of 105 Cases

et al. 2022

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Background and Objectives: Solid-organ transplant recipients (SOTRs) are notably considered at risk for developing cutaneous malignancies. However, most of the existing literature is focused on kidney transplant-related non-melanoma skin cancers (NMSCs). Conflicting data have been published so far on NMSC incidence among liver transplant recipients (LTRs), and whether LTRs really should be considered at lower risk remains controversial. The aim of the present study was to prospectively collect data on the incidence of cutaneous neoplasms in an LTR cohort. Materials and Methods: All LTRs transplanted at the Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit of Modena University Hospital from October 2015 to June 2021 underwent a post-transplant periodic skin check at the Dermatology Unit according to our institutional integrated care pathway. Data on the presence of cutaneous malignant and premalignant lesions were collected at every timepoint. Results: A total of 105 patients were enrolled in the present study. Nearly 15% of the patients developed cutaneous cancerous and/or precancerous lesions during the follow-up period. Almost half of the skin cancerous lesions were basal cell carcinomas. Actinic keratoses (AKs) were observed in six patients. Four patients developed in situ squamous cell carcinomas, and one patient was diagnosed with stage I malignant melanoma. Otherwise, well-established risk factors for the occurrence of skin tumors, such as skin phototype, cumulative sun exposure, and familial history of cutaneous neoplasms, seemed to have no direct impact on skin cancer occurrence in our cohort, as well as an immunosuppressive regimen and the occurrence of non-cutaneous neoplasms. Conclusions: Close dermatological follow-up is crucial for LTRs, and shared protocols of regular skin checks in this particular subset of patients are needed in transplant centers.

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Section: Introductionmentioning

confidence: 99%

De Novo Skin Neoplasms in Liver-Transplanted Patients: Single-Center Prospective Evaluation of 105 Cases

et al. 2022

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“…(4) Some of the risk factors associated with the development of post-transplant malignancy in recipients of liver transplants include advanced age, smoking, alcohol consumption, oncogenic viruses, and long-term use of immunosuppression. (5,6) The most common malignancies that develop in recipients of liver transplants are post-transplant lymphoproliferative diseases and skin tumors in the pediatric and adult populations, respectively. These are closely followed by colorectal malignancies and lung cancers.…”

Section: Introductionmentioning

confidence: 99%

Surgical Management of Gastric Cancer With a History of Liver Transplantation: Case Report

Alabdallat

Tamam

Çulcu

et al. 2023

Preprint

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Rationale: The number of solid organ transplants has increased worldwide. Liver transplantation is an effective treatment of end-stage liver disease and some selected malignancies. The increased life expectancy has resulted in an increase in comorbidities after transplantation, including de novo malignancies. Gastric cancer after a liver transplant is not prevalent. In this case report, we report the case of a patient who presented with gastric cancer after liver transplantation. Patient concerns: Our patient is a 62-year-old male patient who received liver transplantation three years ago. About 36 months after transplantation, the patient presented with upper gastrointestinal bleeding. Diagnosis: A decision was taken to do upper gastrointestinal endoscopy, which revealed a 5-centimeter tumour on the greater curvature. A biopsy of the tumour was done, and the histology revealed Adenocarcinoma. Interventions: The patient underwent open total gastrectomy with D2 dissection and esophagojejunal anastomosis. Outcomes: The postoperative period of the patient was uneventful, and the patient was discharged after 10 days. Lessons: The mainstay of treatment of gastric cancer in recipients of liver transplantation is gastrectomy with D2 dissection. Prompt diagnosis and surgical management are required to treat these patients, and during the perioperative period, the immunosuppressive medications should be continued to prevent graft rejection.

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Is diabetes a risk factor for malignancy post-transplant in liver transplant recipients?

Congly

2022

Annals of Hepatology

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Predictors of solid extra-hepatic non-skin cancer in liver transplant recipients and analysis of survival: A long-term follow-up study

Cited by 6 publications

References 35 publications

De Novo Skin Neoplasms in Liver-Transplanted Patients: Single-Center Prospective Evaluation of 105 Cases

De Novo Skin Neoplasms in Liver-Transplanted Patients: Single-Center Prospective Evaluation of 105 Cases

Surgical Management of Gastric Cancer With a History of Liver Transplantation: Case Report

Is diabetes a risk factor for malignancy post-transplant in liver transplant recipients?

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