Predictors of social instability stress effects on social interaction and anxiety in adolescent male rats

Hodges, Travis E.; Baumbach, Jennet L.; McCormick, Cheryl M.

doi:10.1002/dev.21626

Cited by 19 publications

(21 citation statements)

References 71 publications

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“…In contrast to saccharin preference and behavior in the open field and elevated-plus maze, active social interaction was only affected by hippocampal-kindling, but not in response to amygdala-kindling. Social isolation and disorganized social interaction complexity have been reported previously as a consequence of distress [37][38][39]. Thus, the increase in active social interaction in the absence of aggressive behavior is rather not interpreted as an indicator of an increased level of distress.…”

Section: Discussionmentioning

confidence: 92%

Toward evidence-based severity assessment in mouse models with repeated seizures: I. Electrical kindling

Boldt

Koska

Dijk

et al. 2021

Epilepsy & Behavior

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Objective: Ethical decisions about an allowance for animal experiments need to be based on scientifically sound information about the burden and distress associated with the experimental procedure and models. Thereby, species differences need to be considered for recommendations regarding evidence-based severity assessment and refinement measures. Methods: A comprehensive analysis of behavioral patterns and corticosterone or its metabolites in serum and feces was completed in kindled mice. The impact of kindling via two different stimulation sites in the amygdala and hippocampus was determined. Data were compared to those from naive and electrodeimplanted groups. Results: Amygdala and hippocampus kindled mice exhibited comparable behavioral patterns with increased activity in the open field, reduced anxiety-associated behavior in the elevated-plus maze, and increased anhedonia-associated behavior in the saccharin preference test. In addition, repeated stimulation of the hippocampus caused a reduction in burrowing behavior and an increase in active social interaction. Levels of corticosterone and its metabolites were not altered in serum or feces, respectively. A comparison of mouse data with findings from amygdala kindled rats confirmed pronounced species differences in behavioral patterns associated with the kindling process. Significance: Taken together the findings suggest a severity classification for the mouse kindling paradigms as moderate regardless of the stimulation site. The outcome of the species comparison provides valuable guidance for species selection for studies exploring behavioral comorbidities. In this context, it is emphasized that the mouse kindling paradigms seem to be well suited for studies exploring the link between ictal events and network alterations on the one hand, and hyperactivity and anhedoniaassociated behavior on the other hand. Moreover, the underlying pathophysiological mechanisms and the impact of therapeutic interventions on these behavioral alterations can be studied in these paradigms providing guidance for the clinical management of respective psychiatric comorbidities in patients.

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Section: Discussionmentioning

confidence: 92%

Toward evidence-based severity assessment in mouse models with repeated seizures: I. Electrical kindling

Boldt

Koska

Dijk

et al. 2021

Epilepsy & Behavior

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“…Exposure to RSD produced a short-term deficit of social interaction. This reduction of the ISI in defeated mice has been associated with the social avoidance that characterizes affective disorders (Golden et al, 2011), and has been repeatedly observed after RSD or social instability (Krishnan et al, 2007;Golden et al, 2011;Henriques-Alves and Queiroz, 2016;Browne et al, 2018;Dong et al, 2018;Hodges et al, 2018). Furthermore, the ISI is the most used measure to distinguish between mice that are resilient or vulnerable to the effects of different models of social defeat (Krishnan et al, 2007;Chaudhury et al, 2013;Donahue et al, 2014;Friedman et al, 2014;Hodes et al, 2014;Isingrini et al, 2016;Sun et al, 2016;Nelson et al, 2018;Prabhu et al, 2018;Gururajan et al, 2019).…”

Section: Resilience To the Long-term Effects Of Rsd On Cocaine Cpp Ismentioning

confidence: 93%

“…The influence that the novelty-seeking trait exerts on vulnerability to stress and drug use has been repeatedly demonstrated (Kabbaj et al, 2001;Duclot et al, 2011;Vidal-Infer et al, 2012;Duclot and Kabbaj, 2013;Clinton et al, 2014;Hodges et al, 2018). In particular, novelty-seeking behavior is one of the personality factors that may explain individual differences in vulnerability to drug abuse (Dellu et al, 1996).…”

Section: Resilience To the Long-term Effects Of Rsd On Cocaine Cpp Ismentioning

confidence: 99%

Behavioral Traits Associated With Resilience to the Effects of Repeated Social Defeat on Cocaine-Induced Conditioned Place Preference in Mice

Calpe-López

García-Pardo

Martínez-Caballero

et al. 2020

Front. Behav. Neurosci.

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The relationship between stress and drug use is well demonstrated. Stress-induced by repeated social defeat (RSD) enhances the conditioned place preference (CPP) induced by cocaine in mice. The phenomenon of resilience understood as the ability of subjects to overcome the negative effects of stress is the focus of increasing interest. Our aim is to characterize the behavior of resilient animals with respect to the effects of RSD on the CPP induced by cocaine. To this end, 25 male C57BL/6 mice were exposed to stress by RSD during late adolescence, while other 15 male mice did not undergo stress (controls). On the 2 days following the last defeat, all the animals carried out the elevated plus maze (EPM) and Hole Board, Social Interaction, Tail Suspension and Splash tests. Three weeks later, all the animals performed the CPP paradigm with a low dose of cocaine (1 mg/kg). Exposure to RSD decreased all measurements related to the open arms of the EPM. It also reduced social interaction, immobility in the tail suspension test (TST) and grooming in the splash test. RSD exposure also increased the sensitivity of the mice to the rewarding effects of cocaine, since only defeated animals acquired CPP. Several behavioral traits were related to resilience to the potentiating effect of RSD on cocaine CPP. Mice that showed less submission during defeat episodes, a lower percentage of time in the open arms of the EPM, low novelty-seeking, high social interaction, greater immobility in the TST and a higher frequency of grooming were those that were resilient to the long-term effects of social defeat on cocaine reward since they behaved like controls and did not develop CPP. These results suggest that the behavioral profile of resilient defeated mice is characterized by an active coping response during episodes of defeat, a greater concern for potential dangers, less reactivity in a situation of inevitable moderate stress and fewer depressive-like symptoms after stress. Determining the neurobehavioral substrates of resilience is the first step towards developing behavioral or pharmacological interventions that increase resilience in individuals at a high risk of suffering from stress.

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“…Additionally, whether our results suggest a positive effect of social interaction on reducing CPP for cocaine, it could constitute a key element within treatment avenues. In addition, we analysed the pattern of c-Fos expression which has shown to be a reliable marker to characterise neuronal activation in brain regions involved in addiction circuitry (Cruz et al, 2015; Kabbaj and Akil, 2001; Regier et al, 2012) as well as in social interaction (Hodges et al, 2018; Perkins et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

The presence of a social stimulus reduces cocaine-seeking in a place preference conditioning paradigm

et al. 2019

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Background: One challenge in the treatment of substance use disorders is to re-engage the interest toward non-drug-related activities. Among these activities, social interaction has had a prominent role due to its positive influence on treatment outcome. Aims and methods: Our aim was to study whether the presence of a social stimulus during the cocaine-induced conditioned place preference test was able to reduce the time spent in the drug-paired compartment. For that purpose, mice were trained for four days on a conditioned place preference task with one compartment paired with cocaine and the opposite with saline. On the test day, we introduced an unfamiliar juvenile male mouse into the saline-conditioned compartment (inside a pencil cup) to analyse the animal preference towards the two rewarding stimuli (cocaine vs mouse). Additionally, to discard the possible effect of novelty, as well as the housing condition (social isolation) on social preference, we decided to include a novel object during the test session, as well as perform the same conditioned place preference protocol with a group of animals in social housing conditions. Results: The social stimulus was able to reduce the preference for cocaine and enhance the active interaction with the juvenile mouse (sniffing) compared to the empty pencil cup paired with the drug. The introduction of a novel object during the test session did not reduce the preference for the cocaine-paired compartment, and interestingly, the preference for the social stimulus was independent of the housing condition. c-Fos immunohistochemistry revealed a different pattern of activation based on cocaine-paired conditioning or the presence of social stimulus. Conclusions: These results suggest that social interaction could constitute a valuable component in the treatment of substance use disorders by reducing the salience of the drug.

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Predictors of social instability stress effects on social interaction and anxiety in adolescent male rats

Cited by 19 publications

References 71 publications

Toward evidence-based severity assessment in mouse models with repeated seizures: I. Electrical kindling

Toward evidence-based severity assessment in mouse models with repeated seizures: I. Electrical kindling

Behavioral Traits Associated With Resilience to the Effects of Repeated Social Defeat on Cocaine-Induced Conditioned Place Preference in Mice

The presence of a social stimulus reduces cocaine-seeking in a place preference conditioning paradigm

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