Predictors of Short- and Long-Term Outcomes of Takotsubo Cardiomyopathy

Gopalakrishnan, Mukesh; Hassan, Abdalla; Villines, Dana; Nasr, Sharif; Chandrasekaran, Mercy; Klein, Lloyd W.

doi:10.1016/j.amjcard.2015.08.024

Cited by 48 publications

(23 citation statements)

References 20 publications

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“…3). In-hospital cardiac mortality from TCM ranges from 0 to 2% (3,13) while all-cause mortality ranges from 0 to 9% (2,6,13,14). A diagnosis of TCM as a cause of cardiac arrest and shock can only be made if the patient survives the initial insult (15).…”

Section: Discussionmentioning

confidence: 99%

Estimation of Risk Factors for Cardiogenic Shock in Takotsubo Cardiomyopathy: A Retrospective Study

Vaidya

Madhira

2017

ICFJ

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Introduction: Presentation of Takotsubo cardiomyopathy(TCM) widely varies amongst the patients, ranging from asymptomatic patients to cardiogenic shock or even cardiac arrest. The underlying risk factors inherent to the patient that predispose to a catastrophic presentation have not been delineated well in the past.Objective: To distinguish risk factors and presenting characteristics of patients diagnosed with cardiogenic shock from TCM.Methods: Total 51 angiography-confirmed TCM patients admitted in Upstate Hospital from 2010 – 2014 were compared retrospectively, 13 presenting with cardiogenic shock.Results: While TCM was predominantly common in elderly females, four of the total six male TCM patients presented with shock (Odds ratio= 8.0, p=0.027). TSH was higher in cardiogenic shock group. Patients with shock had significantly higher incidence of ST elevations on EKG and higher peak troponins. Moreover, ST elevations were predominantly in the inferior, anteroseptal and lateral leads in the shock group as compared to only the septal leads in the control group. Echocardiography revealed lower LV ejection fraction, LV outflow tract obstruction and concomitant significant mitral regurgitation in shock patients. No correlation was found with age, BMI, coronary disease risk factors (diabetes, hypertension, smoking), coincident infection, electrolyte imbalance, QTc interval length.Conclusion: Risk factors and pathophysiology for cardiogenic shock in TCM were identified. TCM in males is rare, but male gender is a risk factor for shock.

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Section: Discussionmentioning

confidence: 99%

Estimation of Risk Factors for Cardiogenic Shock in Takotsubo Cardiomyopathy: A Retrospective Study

Vaidya

Madhira

2017

ICFJ

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“…Niestety w ostrej fazie choroby może dojść do wielu powikłań, takich jak ostra niewydolność serca, obrzęk płuc, wstrząs kardiogenny, ostra niedomykalność mitralna (MR, mitral regurgitation), dysfunkcja prawej komory (RV, right ventricle), zawężanie drogi odpływu LV, skrzeplina w LV, pęknięcie LV, przegrody międzykomorowej lub zaburzenia rytmu serca. Większość publikacji ocenia śmiertelność krótkoterminową na 2-3% [13,15,16], jednak w niektórych badaniach sięga ona 8,9% [17]. W dużym rejestrze obejmującym 24 701 pacjentów śmiertelność wewnątrzszpitalna wynosiła 4,2% [18].…”

Section: Rokowanie Krótkoterminoweunclassified

“…Krótszy skorygowany odstęp QT był związany z wyższym ryzykiem zgonu w czasie obserwacji odległej [26].…”

Section: Rokowanie Długoterminoweunclassified

Parametry echokardiograficzne wpływające na rokowanie pacjentów z kardiomiopatią takotsubo

Budnik

2017

Folia Cardiologica

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StreszczenieKardiomiopatia takotsubo to odwracalna dysfunkcja skurczowa lewej komory, której objawy przypominają ostry zespół wieńcowy. Rokowanie jest na ogół korzystne -w ciągu kilku tygodni dochodzi do poprawy funkcji skurczowej lewej komory, jednak czasami występują powikłania, takie jak ostra niedomykalność mitralna, dysfunkcja prawej komory, zawężanie drogi odpływu lewej komory, skrzeplina w lewej komorze, ostra niewydolność serca lub wstrząs kardiogenny, które mogą nawet prowadzić do zgonu. Dlatego niezwykle istotne jest znalezienie czynników, które wpływają na rokowanie pacjentów, a które są łatwo i szybko dostępne.Słowa kluczowe: takotsubo, zespół balotującego koniuszka, kardiomiopatia stresowa Cardiologica 2016; 11, 6: 569-574 Folia

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“…Mortality is similar compared to patients with ACS from other causes [14,15] and increased compared to control subject with reported chest pain [4]. Common complications include cardiogenic shock [16], arrhythmias [7] and death [5].…”

Section: Introductionmentioning

confidence: 99%

“…There are four types based on cardiac catheterization findings including the apical type (> 80% of cases), midventricular type, basal type and focal type [4]. The most common presenting symptoms are acute chest pain and dyspnea while associated clinical findings include elevation in cardiac enzymes and electrocardiogram (ECG) changes [5,6]. Other laboratory abnormalities include elevated brain natriuretic peptide (BNP) and BNP/peak troponin ratio when compared to ST-elevation myocardial infarction patients [7].…”

Section: Introductionmentioning

confidence: 99%

Lesser Severity of Recurrent Takotsubo Cardiomyopathy While Taking Angiotensin II Receptor Blocker and Beta Blocker

et al. 2018

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Takotsubo cardiomyopathy (TC) is characterized by transient systolic and diastolic dysfunction, ventricular wall motion abnormalities and troponin elevation. The most common presenting symptoms are acute chest pain and dyspnea. The etiology is unknown but believed to be related to a surge in catecholamines as it is commonly associated with a preceding physical or emotional stress. Due to the lack of specific treatment, recurrence occurs in 2-12% of patients per year. We present a case of a patient with TC subsequently treated with an angiotensin II receptor blocker (ARB) and beta-adrenergic blocker (beta-blocker). A repeat TC episode 4 months later showed less severely abnormal cardiac enzymes, echocardiogram and overall hospital course. Because our patient experienced a classic episode of TC and a recurrent episode with milder symptoms and lower troponins, we hypothesize her medication regimen was a contributing factor to the milder manifestation of this cardiac syndrome.

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Predictors of Short- and Long-Term Outcomes of Takotsubo Cardiomyopathy

Cited by 48 publications

References 20 publications

Estimation of Risk Factors for Cardiogenic Shock in Takotsubo Cardiomyopathy: A Retrospective Study

Estimation of Risk Factors for Cardiogenic Shock in Takotsubo Cardiomyopathy: A Retrospective Study

Parametry echokardiograficzne wpływające na rokowanie pacjentów z kardiomiopatią takotsubo

Lesser Severity of Recurrent Takotsubo Cardiomyopathy While Taking Angiotensin II Receptor Blocker and Beta Blocker

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