Predictors of Serum Vitamin D Levels in African American and European American Men in Chicago

Kelley, Brian M.; Nyame, Yaw A.; Martin, Iman K.; Smith, Demetria J.; Castaneda, Lauren; Zagaja, Gregory J.; Hollowell, Courtney M.P.; Kittles, Rick A.

doi:10.1177/1557988312437240

Cited by 39 publications

(47 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We are using this measure as a proxy for early lifetime vitamin D deficiency or chronic deficiency in EA and AA men. We, and other investigators, have shown that the biggest determinant of serum 25-OH D level in Chicago for EA men was sun exposure (12, 35) and for AA men the major determinant was skin color. Sun exposure due to recreational activity may decline with aging whereas skin color is relatively stable.…”

Section: Discussionmentioning

confidence: 46%

“…skin color). Furthermore, AA men would rarely have high levels of vitamin D, which may make associations between cancer status and vitamin D deficiency easier to detect (12, 36). …”

Section: Discussionmentioning

confidence: 99%

“…There were small numbers of Hispanics, Asians and were excluded. We stratified the analyses by EA and AA race, since AA men have higher rates of positive biopsy (20), higher Gleason grade and stage at presentation (21), and higher prevalence of vitamin D deficiency (12, 13). …”

Section: Methodsmentioning

confidence: 99%

“…For the majority of individuals, approximately 90% of vitamin D is estimated to derive from sunshine, with the liver converting solar ultraviolet (UV) radiation into 25-hydroxyvitamin D3 (25-OH D3), the form of vitamin D typically measured in blood serum (11). AA men have lower serum vitamin D levels than their European American and Hispanic counterparts (12, 13) in part due to lower skin synthesis from the UV blocking effects of melanin in the skin (14-17). A recent epidemiologic study suggests that vitamin D deficiency may explain the disparity in cancer survival between European Americans and AAs, including PCa (18)…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Vitamin D Deficiency Predicts Prostate Biopsy Outcomes

Murphy

Nyame

Martin

et al. 2014

Clinical Cancer Research

Self Cite

View full text Add to dashboard Cite

Purpose The association between vitamin D and prostate biopsy outcomes has not been evaluated. We examine serum vitamin D levels with prostate biopsy results in men with abnormal PSA and/or digital rectal examination. Experimental Design Serum 25-hydroxyvitamin D (25-OH D) was obtained from 667 men, age 40-79, prospectively enrolled from Chicago urology clinics undergoing first prostate biopsy. Logistic regression was used to evaluate the associations between 25-OH D status and incident prostate cancer (PCa), Gleason score, and tumor stage. Results Among European American (EA) men, there was an association of 25-OH D < 12 ng/ml with higher Gleason score ≥ 4+4 (OR = 3.66 [1.41, 9.50], p = 0.008) and tumor stage (stage ≥ cT2b vs. ≤ cT2a, OR = 2.42 [1.14, 5.10], p = 0.008). In African American (AA) men, we find increased odds of PCa diagnosis on biopsy with 25-OH D < 20 ng/ml (OR = 2.43 [1.20, 4.94], p = 0.01). AA men demonstrated an association between 25-OH D < 12ng/ml and Gleason ≥ 4+4 (OR = 4.89 [1.59, 15.07]; p = 0.006). There was an association with tumor stage ≥ cT2b vs. ≤ cT2a (OR: 4.22, [1.52 – 11.74], p = 0.003). Conclusions In AA men, vitamin D deficiency was associated with increased odds of PCa diagnosis on biopsy. In both EA and AA men, severe deficiency was positively associated with higher Gleason grade and tumor stage.

show abstract

Section: Discussionmentioning

confidence: 46%

“…skin color). Furthermore, AA men would rarely have high levels of vitamin D, which may make associations between cancer status and vitamin D deficiency easier to detect (12, 36). …”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Vitamin D Deficiency Predicts Prostate Biopsy Outcomes

Murphy

Nyame

Martin

et al. 2014

Clinical Cancer Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, previously, we demonstrated that serum vitamin D levels were associated with prostate biopsy outcome and adverse pathology after undergoing radical prostatectomy in our study group [18, 29], and this is the first study to demonstrate significant association between vitamin D intake and PCa. Compared to other work, our study has the advantage of including a large number of AA participants and men living in a low ultraviolet radiation environment who were vitamin D deficient [14, 15]. …”

Section: Discussionmentioning

confidence: 99%

Race and BMI modify associations of calcium and vitamin D intake with prostate cancer

et al. 2017

Self Cite

View full text Add to dashboard Cite

BackgroundAfrican Americans have disproportionately higher burden of prostate cancer compared to European Americans. However, the cause of prostate cancer disparities is still unclear. Several roles have been proposed for calcium and vitamin D in prostate cancer pathogenesis and progression, but epidemiologic studies have been conducted mainly in European descent populations. Here we investigated the association of calcium and vitamin D intake with prostate cancer in multiethnic samples.MethodsA total of 1,657 prostate cancer patients who underwent screening and healthy controls (888 African Americans, 620 European Americans, 111 Hispanic Americans, and 38 others) from Chicago, IL and Washington, D.C. were included in this study. Calcium and vitamin D intake were evaluated using food frequency questionnaire. We performed unconditional logistic regression analyses adjusting for relevant variables.ResultsIn the pooled data set, high calcium intake was significantly associated with higher odds for aggressive prostate cancer (ORQuartile 1 vs. Quartile 4 = 1.98, 95% C.I.: 1.01–3.91), while high vitamin D intake was associated with lower odds of aggressive prostate cancer (ORQuartile 1 vs. Quartile 4 = 0.38, 95% C.I.: 0.18–0.79). In African Americans, the association between high calcium intake and aggressive prostate cancer was statistically significant (ORQuartile 1 vs. Quartile 4 = 4.28, 95% C.I.: 1.70–10.80). We also observed a strong inverse association between total vitamin D intake and prostate cancer in African Americans (ORQuartile 1 vs. Quartile 4 = 0.06, 95% C.I.: 0.02–0.54). In European Americas, we did not observe any significant associations between either calcium or vitamin D intake and prostate cancer. In analyses stratifying participants based on Body Mass Index (BMI), we observed a strong positive association between calcium and aggressive prostate cancer and a strong inverse association between vitamin D intake and aggressive prostate cancer among men with low BMI (<27.8 kg/m2), but not among men with high BMI (≥27.8 kg/m2). Interactions of race and BMI with vitamin D intake were significant (P Interaction < 0.05).ConclusionCalcium intake was positively associated with aggressive prostate cancer, while vitamin D intake exhibited an inverse relationship. However, these associations varied by race/ethnicity and BMI. The findings from this study may help develop better prostate cancer prevention and management strategies.Electronic supplementary materialThe online version of this article (doi:10.1186/s12885-017-3060-8) contains supplementary material, which is available to authorized users.

show abstract

Association among plasma 1,25(OH)₂D, ratio of 1,25(OH)₂D to 25(OH)D, and prostate cancer aggressiveness

et al. 2019

View full text Add to dashboard Cite

Background African‐American (AA) men tend to present with more aggressive prostate cancer (Gleason score >7) than European‐American (EA) men. Vitamin D and its metabolites are implicated in prostate cancer biology with vitamin D deficiency, indicated by its metabolite levels in serum or plasma, usually observed in AA men. Objective To determine if 1, 25‐dihydroxy vitamin D3 [1,25(OH) 2 D] plasma levels in AA and EA prostate cancer patients alter the risk of having aggressive prostate cancer. Design Research subjects from the North Carolina‐Louisiana Prostate Cancer Project (AA n = 435 and EA n = 532) were included. Plasma metabolites 1,25(OH) 2 D and 25‐hydroxyvitamin D3 [25(OH)D] were measured using liquid chromatography with tandem mass spectrophotometry. Research subjects were classified into low (Gleason sum < 7, stage T1‐T2, and Prostate‐specific antigen (PSA) < 9 ng/mL) or high (Gleason sum > 8 or Gleason sum = 7 with 4 + 3, or PSA > 20 ng/mL, or Gleason sum = 7 and stage T3‐T4) aggressive disease. Results Research subjects in the second and third tertiles of plasma levels of 1, 25(OH) 2 D had lower odds of high aggressive prostate cancer (AA [OR T2vsT1 : 0.66, 95%CI: 0.39‐1.12; OR T3vsT1 : 0.83, 95%CI: 0.49‐1.41] and EA [OR T2vsT1 : 0.68, 95%CI: 0.41‐1.11; OR T3vsT1 : 0.67, 95%CI: 0.40‐1.11]) compared with the first tertile, though confidence intervals included the null. Greater 1,25(OH) 2 D/25(OH)D molar ratios were associated with lower odds of high aggressive prostate cancer more evidently in AA (OR Q4vsQ1 : 0.45, CI: 0.24‐0.82) than in EA (OR Q4vsQ1 : 0.64, CI: 0.35‐1.17) research subjects. Conclusions The 1,25(OH) 2 D/25(OH)D molar ratio was associated with decreased risk of high aggressive prostate cancer in AA men, and possibly in EA men. Further studies analyzing vitamin D polymorphisms, vitamin D binding protein levels, and prostatic levels of these metabolites may be useful. These studies may provide a better understanding of the vitamin D pathway and its biological role underlying health disparities in prostate cancer.

show abstract

Predictors of Serum Vitamin D Levels in African American and European American Men in Chicago

Cited by 39 publications

References 31 publications

Vitamin D Deficiency Predicts Prostate Biopsy Outcomes

Vitamin D Deficiency Predicts Prostate Biopsy Outcomes

Race and BMI modify associations of calcium and vitamin D intake with prostate cancer

Association among plasma 1,25(OH)₂D, ratio of 1,25(OH)₂D to 25(OH)D, and prostate cancer aggressiveness

Contact Info

Product

Resources

About

Predictors of Serum Vitamin D Levels in African American and European American Men in Chicago

Cited by 39 publications

References 31 publications

Vitamin D Deficiency Predicts Prostate Biopsy Outcomes

Vitamin D Deficiency Predicts Prostate Biopsy Outcomes

Race and BMI modify associations of calcium and vitamin D intake with prostate cancer

Association among plasma 1,25(OH)2D, ratio of 1,25(OH)2D to 25(OH)D, and prostate cancer aggressiveness

Contact Info

Product

Resources

About

Association among plasma 1,25(OH)₂D, ratio of 1,25(OH)₂D to 25(OH)D, and prostate cancer aggressiveness