Predictors of Serum Total IgE in a Random Sample of 7–17 Year Old Children

Abstract

Background. There is little knowledge of the causes for raised serum total immunoglobulin E (IgE) in children. We investigated the association between perinatal, socioeconomic, demographic, clinical, paraclinical, and early life factors, and total serum IgE. Methods. In a random sample of 7–17 year old children, data on possible risk factors were collected using a questionnaire and total serum IgE was measured in venous blood. Airway responsiveness to inhaled histamine was measured and skin prick tests were performed using common aeroallergens. Data was analysed using linear regression. Results. Positive skin prick test (P < .001), airway hyperresponsiveness (P = .003), atopic dermatitis (P = .046), and parental predisposition to allergy (P = .047) showed a significant relation to serum total IgE levels. There was no association of smoking to serum total IgE. Conclusions. This study showed a strong positive relationship between markers of the atopic syndrome and serum total IgE levels in children. In contrast to some earlier studies, we did not find a significant relation between smoking status and IgE.

Association between infection with Helicobacter pylori and atopy in young Ethiopian children: A longitudinal study

“…The role of total IgE as a biomarker for atopy and allergic disease has been suggested in several studies . Two cross‐sectional studies by Burrows et al .…”

“…and Sunyer et al., reported an independent effect of total IgE on asthma using the data from Tucson and the European Community Respiratory Health Survey (ECRHS) study, respectively. Others demonstrated a strong positive relationship between markers of the atopic syndrome and serum total IgE levels in children, and suggested total IgE as a tool to discriminate those with and without atopy …”

“…51 The role of total IgE as a biomarker for atopy and allergic disease has been suggested in several studies. 39,[51][52][53] Two cross-sectional studies by Burrows et al 39 and Sunyer et al, 52 reported an independent effect of total IgE on asthma using the data from Tucson and T A B L E 4 Associations between atopy at age 6.5 y and CagA Helicobacter pylori exposure at 6.5 y, Butajira birth-cohort study, Ethiopia. 53 and suggested total IgE as a tool to discriminate those with and without atopy.…”

“…39,[51][52][53] Two cross-sectional studies by Burrows et al 39 and Sunyer et al, 52 reported an independent effect of total IgE on asthma using the data from Tucson and T A B L E 4 Associations between atopy at age 6.5 y and CagA Helicobacter pylori exposure at 6.5 y, Butajira birth-cohort study, Ethiopia. 53 and suggested total IgE as a tool to discriminate those with and without atopy. 51 Despite these observations, however, elevated IgE levels are occasionally observed in disorders like parasitic infection, 48 myeloma 54 and chronic inflammatory bowel diseases.…”

AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer—a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI)

“…In a non-selected Austrian adolescent cohort, male gender was associated with higher sensitization frequency (56.8%) compared to females, while family size and growing up on a farm inversely-correlated with ssIgE levels [ 90 ]. After multivariant adjustment in a random sample of Danish children, positive skin prick test, airway hyperresponsiveness, atopic dermatitis, and parental predisposition remained significant predictors of total serum IgE [ 91 ]. Smokers and those with occupational dust or gas exposure have higher mean logarithmic IgE values than non‐smokers and unexposed individuals [ 92 ].…”