Predictors of Screening for AIDS Clinical Trials Among African-Americans and Latino/Hispanics Enrolled in an Efficacious Peer-Driven Intervention: Uncovering Socio-Demographic, Health, and Substance Use-Related Factors That Promote or Impede Screening

Gwadz, Marya; Cleland, Charles M.; Leonard, Noelle R.; Ritchie, Amanda S.; Banfield, Angela; Riedel, Marion; Colon, Pablo; Mildvan, Donna

doi:10.1007/s10461-012-0194-1

Cited by 9 publications

(14 citation statements)

References 45 publications

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“…27 While several studies and policy statements have highlighted the benefits to study recruitment and implementation when communities under study are engaged in staffing and recruitment strategies, 15,23,26,28–32 the processes for creating effective, culturally grounded teams have not been widely studied. 15,33 This study explores several key areas to prioritize for more systematic study in implementation research and scale-up of novel programs for black MSM, namely, the hiring and retention of study staff and the development of targeted, community-based recruitment plans.…”

Section: Discussion/lessons Learnedmentioning

confidence: 99%

Engaging, Recruiting, and Retaining Black Men Who Have Sex With Men in Research Studies

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Griffith

Arnold

et al. 2014

Journal of Public Health Management and Practice

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Context HIV/AIDS in the United States continues to primarily impact men who have sex with men (MSM), with disproportionately high rates among black MSM. Objective The purpose of this study was to identify factors that may influence engagement and retention of black MSM in HIV research. Design and Participants This was a qualitative evaluation of study implementation within a multisite, prospective, observational study (HIV Prevention Trials Network 061, BROTHERS) that enrolled 1553 black MSM in 6 cities throughout the United States. Data collection for this evaluation included a written, structured survey collected from each of the sites describing site characteristics including staff and organizational structure, reviews of site standard operating procedures, and work plans; semistructured key informant interviews were conducted with site coordinators to characterize staffing, site-level factors facilitating or impeding effective community engagement, study recruitment, and retention. Data from completed surveys and site standard operating procedures were collated, and notes from key informant interviews were thematically coded for content by 2 independent reviewers. Results Several key themes emerged from the data, including the importance of inclusion of members of the community being studied as staff, institutional hiring practices that support inclusive staffing, cultivating a supportive working environment for study implementation, and ongoing relationships between research institutions and community. Conclusions This study underscores the importance of staffing in implementing research with black MSM. Investigators should consider how staffing and organizational structures affect implementation during study design and when preparing to initiate study activities. Ongoing monitoring of community engagement can inform and improve methods for engagement and ensure cultural relevance while removing barriers for participation.

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Section: Discussion/lessons Learnedmentioning

confidence: 99%

Engaging, Recruiting, and Retaining Black Men Who Have Sex With Men in Research Studies

Magnus

Griffith

Arnold

et al. 2014

Journal of Public Health Management and Practice

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“…These challenges continue even when lifesaving medications are available: barriers to medication adherence and inability to access hard-to-reach populations most in need of interventions continue to stand in the way of adequate treatment in clinical trials settings as well as public health practice. Lack of generalizability of samples to the base population of interest, and failure to include minority populations that reflect those most affected by the epidemic, remain ongoing issues for HIV researchers (1–6,10). This barrier is furthered by inadequate support of institutions of higher learning towards mentorship of underrepresented faculty and staff in both sponsored and non-sponsored research and academic domains.…”

Section: The Critical Role Of Multidisciplinary Teams In Hivmentioning

confidence: 99%

“…Those communities highly affected by HIV can be better engaged and retained by such teams of researchers, and the research made more relevant (1–6). Still, multidisciplinary research is not without challenges.…”

Section: Challenges Of Multidisciplinary Researchmentioning

confidence: 99%

“…Development of research teams who have complementary expertise and representative personnel has been found multiple studies to be key to engaging and retaining participants in population-based samples; it, along with support of diverse research faculty and staffs, is also a crucial component of designing studies capable of examining the sensitive and nuanced issues surrounding HIV-related risk and health utilization behavior (1–6). Understanding barriers to multidisciplinary research is central to being able to overcome them and ultimately developing ways to translate research discovery into improvements in care.…”

Section: Introductionmentioning

confidence: 99%

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Breaking Down the Siloes: Developing Effective Multidisciplinary HIV Research Teams

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Castel

2016

AIDS Behav

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As the HIV epidemic nears its 35 year mark, the role of multidisciplinary approaches to HIV research has become increasingly important. Development of diverse, cross-cutting research teams has been found to be key to engaging and retaining participants in population-based studies; it is also a crucial component of designing studies capable of examining the sensitive and nuanced issues that surround HIV related risk and adherence behavior. Expanding our understanding of these issues is central to being able to overcome them and ultimately to the development of best practices for translation of research discovery into improvements in prevention and care. The objectives of this paper are to characterize the importance of multidisciplinary teams in HIV research where they are critical to gaining information that can have a positive impact on the epidemic and to propose specific methods for creating teams to conduct research with optimal public health impact.

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“…In past research, we described the constellation of individual, social, organizational, and structural barriers that impede access to HAMS for AABH-PLHA [5, 7, 14, 15], which are reviewed in brief below. At the individual level, AABH-PLHA express mistrust of and fears about medical research [15–17].…”

Section: Introductionmentioning

confidence: 99%

ACT2 Peer-Driven Intervention Increases Enrollment into HIV/AIDS Medical Studies Among African Americans/Blacks and Hispanics: A Cluster Randomized Controlled Trial

et al. 2014

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African American/Black and Hispanic persons living with HIV/AIDS (“AABH-PLHA”) are under-represented in HIV/AIDS medical studies (HAMS). This paper evaluates the efficacy of a social/behavioral intervention to increase rates of screening for and enrollment into HAMS in these populations. Participants (N=540) were enrolled into a cluster randomized controlled trial of an intervention designed to overcome multi-level barriers to HAMS. Primary endpoints were rates of screening for and enrollment into therapeutic/treatment-oriented and observational studies. Intervention arm participants were 30 times more likely to be screened than controls (49.3% vs. 3.7%; p < .001). Half (55.5%) of those screened were eligible for HAMS, primarily observational studies. Nine out of ten found eligible enrolled (91.7%), almost all into observational studies (95.2%), compared to no enrollments among controls. Achieving appropriate representation of AABH-PLHA in HAMS necessitates modification of study inclusion criteria to increase the proportion found eligible for therapeutic HAMS, in addition to social/behavioral interventions.

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Predictors of Screening for AIDS Clinical Trials Among African-Americans and Latino/Hispanics Enrolled in an Efficacious Peer-Driven Intervention: Uncovering Socio-Demographic, Health, and Substance Use-Related Factors That Promote or Impede Screening

Cited by 9 publications

References 45 publications

Engaging, Recruiting, and Retaining Black Men Who Have Sex With Men in Research Studies

Engaging, Recruiting, and Retaining Black Men Who Have Sex With Men in Research Studies

Breaking Down the Siloes: Developing Effective Multidisciplinary HIV Research Teams

ACT2 Peer-Driven Intervention Increases Enrollment into HIV/AIDS Medical Studies Among African Americans/Blacks and Hispanics: A Cluster Randomized Controlled Trial

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