Predictors of restenosis: A morphometric and quantitative evaluation by intravascular ultrasound

Jain, Suresh P.; Jain, Ashit; Collins, Tyrone J.; Ramee, Stephen R.; White, Christopher J.

doi:10.1016/0002-8703(94)90262-3

Cited by 53 publications

(21 citation statements)

References 36 publications

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“…[13][14][15] In clinical practice, however, atherosclerotic lesions form the lipid-rich and inflammatory "soil" of restenosis, which is reflected histologically by the presence of foam cells in the restenotic neointima. 16,17 Moreover, pre-intervention plaque burden has been found to be a predictor of restenosis after angioplasty without 18 and with stent implantation. 19 The quest for improved reliability and clinical relevance of preclinical models for postangioplasty restenosis has led to the introduction of double injury protocols, in which dilatation is inflicted on pre-existing atherosclerotic lesions.…”

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confidence: 99%

Adenoviral Transfer of Endothelial Nitric Oxide Synthase Attenuates Lesion Formation in a Novel Murine Model of Postangioplasty Restenosis

Thüsen

Fekkes

Passier

et al. 2004

ATVB

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Objective-Restenosis remains a major late complication of percutaneous transluminal coronary angioplasty (PTCA), for which the development of prevention strategies has thus far been hampered by the lack of a representative and practical animal model. We have, therefore, developed a murine model of PTCA-induced restenosis. Methods and Results-Rigid probe angioplasty of pre-existing atherosclerotic lesions in the carotid arteries of ApoE-deficient mice was found to result in an increase in lesion size (0.14Ϯ0.04ϫ10 5 m 2 to 0.42Ϯ0.09ϫ10 5 m 2 , Pϭ0.007) with a smooth muscle cell-rich, fibrotic lesion morphology. In an additional experiment, lesions were incubated immediately after angioplasty with adenovirus bearing an endothelial nitric oxide synthase (eNOS) transgene (Ad.APT.eNOS), or an "empty" control virus (Ad.APT.empty) at a titer of 1.5ϫ10 9 pfu/mL.

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confidence: 99%

Adenoviral Transfer of Endothelial Nitric Oxide Synthase Attenuates Lesion Formation in a Novel Murine Model of Postangioplasty Restenosis

Thüsen

Fekkes

Passier

et al. 2004

ATVB

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“…However, patients with type C to F dissection had significantly higher rates of in-hospital complications. Jain, et al 34) supported these findings using IVUS. Plaque fracture was noted in only 30% of the restenosis group patients and 74% of the no-restenosis group patients (p=0.04).…”

Section: Discussionmentioning

confidence: 85%

“…Newer techniques such as intravascular ultrasound imaging can visualize the lumen and the vessel wall and thereby detect dissections not visible on the coronary angiogram. 34,39) Indeed, we did not include type A dissections which are angiographically indistinct lesions in our analyses, a pathologic study found intimal-medial injury in 2 of 4 cases. 37) Further, of 5 lesions with intraluminal and extraluminal haziness, all exhibited intimal-medial injury.…”

Section: Discussionmentioning

confidence: 99%

Angiographic Classification of Coronary Dissections after Plain Old Balloon Angioplasty for Prediction of Regression at Follow-up.

et al. 2001

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SUMMARYCoronary dissection after plain old balloon angioplasty often shows regression during follow-up. This study sought to determine whether we can predict such phenomenon angiographically. We analyzed 64 patients with 71 type B-D coronary dissections determined by the National, Heart, Lung, and Blood Institute (NHLBI) criteria. Regression was considered present when minimal lumen diameter increased by more than 0.3 mm during follow-up. Dissections were divided into subgroups using the NHLBI criteria and our classification in which type a and b dissections were characterized by the width of a dissection lumen exceeding one quarter of the reference diameter with the outer edge of the dissection lumen within the boundary of reference in type a and beyond it in type b. In type c and type d dissections, the width of the dissection lumen was within one quarter of the reference with its outer edge within the boundary of reference in type c and beyond it in type d. Type e dissection had a protruding flap or spiral appearance. Regression was recognized in 23.9%. The distribution of dissection types was similar in the groups with and without regression by the NHLBI criteria, but type c dissection had regression more frequently than the other types of coronary dissections (p<0.001) using our classification. (Jpn Heart J 2001; 42: 393-408)

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“…The absence of plaque fracture, the existence of a major dissection, and greater plaque burden were associated with increased incidence of restenosis. 14) On the other hand, Horie et al have reported that serum lipoprotein (a) levels were significantly higher, and fell significantly after PTCA in the restenosis group. 15) We hope to predict restenosis more accurately using both SMMHC levels and intravascular ultrasound imaging.…”

Section: Discussionmentioning

confidence: 97%

Intracoronary Serum Smooth Muscle Myosin Heavy Chain Levels Following PTCA may Predict Restenosis.

et al. 2000

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SUMMARYRecently a novel biochemical method that uses an immunoassay to quantitate serum smooth muscle myosin heavy chain (SMMHC) levels was developed for diagnosis of aortic dissection.1) The purpose of this study was to determine whether SMMHC released from the coronary arterial wall can be used to predict restenosis after percutaneous transluminal coronary angioplasty (PTCA). Fifty-two consecutive patients undergoing successful PTCA for single vessel disease were examined (40 men, 12 women, 63 ± 8 years). Intracoronary blood samples were obtained distal to the lesion, and from the femoral artery after PTCA. In 10 patients, blood samples were taken immediately after the final balloon inflation, and 10 and 20 minutes after PTCA. SMMHC levels were measured by ELISA using SMMHC-specific monoclonal antibodies. Follow-up coronary angiography was performed 3 months after PTCA. Intracoronary serum SMMHC levels were significantly higher than those obtained from the femoral artery (10.6 ± 1.5 vs 2.1 ± 0.1 ng / ml, p 0.001). Of 40 patients without apparent dissection, the 23 patients who did not develop restenosis in the follow-up study were found to have had higher levels of intracoronary SMMHC levels immediately after PTCA compared to the 17 patients with restenosis (15.2 ± 2.9 vs 7.1 ± 1.2 ng / ml, p 0.05). We suggest that elevated intracoronary SMMHC levels after PTCA may reflect the extent of injury to the arterial wall. Intracoronary SMMHC may be a possible biochemical marker for the prediction of

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Predictors of restenosis: A morphometric and quantitative evaluation by intravascular ultrasound

Cited by 53 publications

References 36 publications

Adenoviral Transfer of Endothelial Nitric Oxide Synthase Attenuates Lesion Formation in a Novel Murine Model of Postangioplasty Restenosis

Adenoviral Transfer of Endothelial Nitric Oxide Synthase Attenuates Lesion Formation in a Novel Murine Model of Postangioplasty Restenosis

Angiographic Classification of Coronary Dissections after Plain Old Balloon Angioplasty for Prediction of Regression at Follow-up.

Intracoronary Serum Smooth Muscle Myosin Heavy Chain Levels Following PTCA may Predict Restenosis.

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