Predictors of Response to Acute Treatment of Chronic and Double Depression With Sertraline or Imipramine

Hirschfeld, Robert M. A.; Russell, James M.; Delgado, Pedro L.; Fawcett, Jan; Friedman, Richard A.; Harrison, Wilma; Koran, Lorrin M.; Miller, Ivan W.; Thase, Michael E.; Howland, Robert H; Connolly, Margaret A.; Miceli, R. J.

doi:10.4088/jcp.v59n1205

Cited by 115 publications

(84 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…That is, it is possible that these individuals established social networks and interpersonal ties that were supportive, secure, and positive, thus augmenting treatment. This possibility dovetails nicely with findings that individuals with more social connections and more supportive social networks are less vulnerable to developing depressive symptomatology and more likely to respond well to depression treatment (Ezquiaga, Garcia, Bravo, & Pallares, 1998;Hirschfeld et al, 1998;Zuroff & Blatt, 2002).…”

Section: Pre-treatment Personality and Treatment Responsesupporting

confidence: 66%

Personality, stressful life events, and treatment response in major depression.

Bulmash¹,

Harkness²,

Stewart³

et al. 2009

Journal of Consulting and Clinical Psychology

View full text Add to dashboard Cite

Major Depression (MD) currently affects over 17 million individuals in North America (Greenberg et al., 2003). Identifying factors predictive of MD treatment response is important for developing more efficacious treatments and better understanding MD vulnerability. The goal of the present study was to examine the main and interactive effects of personality and stressful life events as predictors of MD treatment response.One hundred and thirty-one clinically depressed participants were randomly assigned to either 16-weeks of cognitive behavioural therapy (CBT), interpersonal psychotherapy (IPT), or pharmacotherapy (PT). Personality in the form of trait self-criticism, neediness, and connectedness was assessed at pre and post-treatment using the Depressive Experiences Questionnaire (DEQ; Blatt et al., 1976). Stressful life events experienced during treatment were assessed using the Life Events and Difficulties Schedule (LEDS; Bifulco et al., 1989). Results revealed that amongst individuals scoring lower in pretreatment self-criticism, higher pre-treatment connectedness predicted superior treatment response. As well, amongst individuals scoring lower in pre-treatment neediness, higher pre-treatment connectedness predicted superior treatment response. In terms of personality change, both a reduction in neediness and a reduction in self-criticism over the course of treatment predicted superior treatment response. A personality × stressful life event interaction was also found such that amongst those experiencing a stressful life event during treatment, higher scores on pre-treatment self-criticism predicted poor treatment response. These results suggest that personality and stressful life events play an important role in the treatment of MD. Limitations and clinical implications are discussed.iii Acknowledgements

show abstract

Section: Pre-treatment Personality and Treatment Responsesupporting

confidence: 66%

Personality, stressful life events, and treatment response in major depression.

Bulmash¹,

Harkness²,

Stewart³

et al. 2009

Journal of Consulting and Clinical Psychology

View full text Add to dashboard Cite

show abstract

“…This was addressed in the Chronic and Double Depression study [Hirschfeld et al, 1998]. Contrary to expectation, the presence of the personality disorders did not affect the rate of response to pharmacotherapy for chronic depression.…”

Section: Effect Of Comorbid Personality Disorders On the Treatment Ofmentioning

confidence: 94%

Personality disorders and depression: Comorbidity

Hirschfeld

1999

Depr. Anxi.

View full text Add to dashboard Cite

“…Social support and marital status have been repeatedly associated with increased probability to recover from a depressive episode, as well as good level of functioning and higher educational level. 8,23 At the opposite, other studies failed to detect any difference in response rate according to marital status and social class. 50 Religious belief is usually ignored; however, it has been reported to be associated with earlier remission.…”

Section: Socio-demographical and Psychological Issuesmentioning

confidence: 97%

“…However, the clinical experience is much more multifaceted and the most conservative option would be to exclude all the cases that do not satisfy completely and unanimously the criteria, but this could determine the exclusion of a large number of subjects; in a similar way the over-inclusion of any depression probably will never lead to strong genetic results, given that many other factors intervene in the outcome of broadly considered depression. 8 Moreover, a longitudinal observation has revealed that about 50% of young people hospitalized for a major depressive episode will develop manic or hypomanic episodes in the following 10-15 years, 9 therefore some actually depressive future bipolar subject could be involuntarily included in pharmacogenetic study. It has been also reported that the stability of diagnosis seems to improve as severity increases 10 and that bipolar disorder has probably a stronger genetic load compared to 'major depressive single episode';…”

Section: Clinical Features Of Depressionmentioning

confidence: 99%

Pharmacogenetic studies in depression: a proposal for methodologic guidelines

2007

View full text Add to dashboard Cite

Pharmacogenetic studies in mood disorders are rapidly proliferating after the initial reports linking gene variants to treatment outcomes. However, a considerable range of methodologies has been used, making it difficult to compare results across studies and limiting the representativeness of findings. Specification of sampling source (inpatients vs outpatients, primary vs tertiary settings), standardization of diagnostic systems and treatments, adequate monitoring of compliance through plasma levels, sufficient length of observation (at least 6 weeks for acute antidepressant treatments, though 3-6 months are preferable), the use of a range of response criteria and the inclusion of possible environmental confounding variables (life events, social support, temperament) are all potentially important issues when planning pharmacogenetic studies. We reviewed the state-of-the-art methodology and suggested possible guideline for future studies.

show abstract

Predictors of Response to Acute Treatment of Chronic and Double Depression With Sertraline or Imipramine

Cited by 115 publications

References 0 publications

Personality, stressful life events, and treatment response in major depression.

Personality, stressful life events, and treatment response in major depression.

Personality disorders and depression: Comorbidity

Pharmacogenetic studies in depression: a proposal for methodologic guidelines

Contact Info

Product

Resources

About