Predictors of Residual T1 High Grade on Re-Transurethral Resection in a Large Multi-Institutional Cohort of Patients with Primary T1 High-Grade/Grade 3 Bladder Cancer

Ferro, Matteo; Lorenzo, Giuseppe Di; Buonerba, Carlo; Lucarelli, Giuseppe; Russo, Giorgio Ivan; Cantiello, Francesco; Farhan, Abdal Rahman Abu; Stasi, S. Di; Musi, Gennaro; Hurle, Rodolfo; Serretta, Vincenzo; Busetto, Gian Maria; Berardinis, Ettore De; Perdonà, Sisto; Borghesi, Marco; Schiavina, Riccardo; Almeida, Gilberto Laurino; Bove, Pierluigi; Lima, Estêvão; Grimaldi, Giovanni; Matei, Deliu Victor; Mistretta, Francesco A.; Crişan, Nicolae; Terracciano, Daniela; Verze, Paolo; Battaglia, Michele; Guazzoni, Giorgio; Autorino, Riccardo; Morgia, Giuseppe; Damiano, Rocco; Muto, Matteo; Rocca, Roberto La; Mirone, Vincenzo; Cobelli, Ottavio De; Vartolomei, Mihai Dorin

doi:10.7150/jca.26129

Cited by 29 publications

(24 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ferro et al [19] demonstrated that NLR was a predictor of residual HG disease at re-TURB at univariate but not at multivariate analysis. Racioppi et al [20] reported that higher preoperative NLR could be predictive of poor BCG response in multivariate analysis.…”

Section: Discussionmentioning

confidence: 99%

Impact of systemic inflammatory markers on the response to Hyperthermic IntraVEsical Chemotherapy (HIVEC) in patients with non-muscle-invasive bladder cancer after bacillus Calmette–Guérin failure

Chiancone

Fabiano

Carrino

et al. 2021

Arab Journal of Urology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of systemic inflammatory markers on the response to Hyperthermic IntraVEsical Chemotherapy (HIVEC) in patients with non-muscle-invasive bladder cancer after bacillus Calmette–Guérin failure

Chiancone

Fabiano

Carrino

et al. 2021

Arab Journal of Urology

View full text Add to dashboard Cite

show abstract

“…Our results are consistent with previous research. Ferro et al found that tumor size and the presence of carcinoma in situ are independent predictors to identify patients at risk of residual T1 high-grade bladder cancer after a complete TUR ( 34 ). This suggests that the combination of pathological features and inflammatory status is a good predictor of LN metastasis in patients with T1 high-grade urothelial carcinoma ( 12 ).…”

Section: Discussionmentioning

confidence: 99%

Development and Validation of a Nomogram to Predict Lymph Node Metastasis in Patients With T1 High-Grade Urothelial Carcinoma of the Bladder

Song

Liu

et al. 2020

Front. Oncol.

View full text Add to dashboard Cite

Purpose This study aims to develop and validate a nomogram to predict lymph node (LN) metastasis preoperatively in patients with T1 high-grade urothelial carcinoma. Methods We retrospectively evaluated the data of 2,689 patients with urothelial carcinoma of the bladder (UCB) treated with radical cystectomy (RC) and bilateral lymphadenectomy in two medical centers. Eventually, 412 patients with T1 high-grade urothelial carcinoma were enrolled in the primary cohort to develop a prognostic nomogram designed to predict LN status. An independent validation cohort (containing 783 consecutive patients during the same period) was subjected to validate the predicting model. Binary regression analysis was used to develop the predicting nomogram. We assessed the performance of the nomogram concerning its clinical usefulness, calibration, and discrimination. Results Overall, 69 (16.75%), and 135 (17.24%) patients had LN metastasis in the primary cohort and external validation cohort, respectively. The final nomogram included information on tumor number, tumor size, lymphovascular invasion (LVI), fibrinogen, and monocyte-to-lymphocyte ratio (MLR). The nomogram showed good predictive accuracy and calibration with a concordance index in the primary cohort of 0.853. The application of the nomogram in the external validation cohort still gave good discrimination (C-index, 0.845) and good calibration. The analysis of the decision curve shows that the nomogram has clinical application value. Conclusion The nomogram that incorporated the tumor number, tumor size, LVI, fibrinogen, and MLR showed favorable predictive accuracy for LN metastasis. It may be conveniently used to predict LN metastasis in patients with T1 high-grade urothelial carcinoma and be helpful in guiding treatment decisions.

show abstract

“…HG-NMIBC (Ta and T1 with high-grade/G3) was considered to have a strong correlation with recurrence. 18 After studying our data, we found that the NLR change in HG-NMIBC patients could significantly predict the recurrence status ( Figure 5 , Table 5 ). However, in LG-NMIBC patients with recurrence, there was no significant change in postoperative NLR.…”

Section: Resultsmentioning

confidence: 86%

Clinical Value of Postoperative Neutrophil-to-Lymphocyte Ratio Change as a Detection Marker of Bladder Cancer Recurrence

Zhang¹,

Lai²,

Wang³

et al. 2021

CMAR

View full text Add to dashboard Cite

Purpose This study investigated the clinical significance of postoperative neutrophil-to-lymphocyte ratio (NLR) changes in bladder cancer recurrence. Patients and Methods For evaluating the predictive value of postoperative dynamic change of NLR, a retrospective cohort study was performed to analyze 213 patients with bladder cancer who underwent surgical treatment from January 2013 to December 2019 at the Affiliated Tumor Hospital of Guangxi Medical University. Baseline characteristics and recurrence-free survival (RFS) were statistically compared, and a multivariate analysis was used to identify prognostic factors. Results Compared with preoperative NLR levels, postoperative decreased NLR in 130 patients and postoperative increased NLR in 83 patients were detected. The 1-, 3- and 5-year RFS rates were 88.0%, 75.4% and 75.4% in the decreased postoperative NLR group, respectively, and 51.2%, 25.8% and 16.1% in the increased postoperative NLR group, respectively (P < 0.05). Kaplan–Meier curves showed that the cumulative DFS rate in the increased group was significantly lower than that in the decreased group (P < 0.05). The preoperative NLR showed significant difference with postoperative NLR in the total cohort, high-grade non-muscle-invasive bladder cancer (HG-NMIBC) and muscle-invasive bladder cancer (MIBC) group, while there was no significant difference between postoperative NLR and NLR of recurrence or last follow-up. Multivariate analysis suggested that postoperative-preoperative NLR was an independent predictor for RFS (HR=6.206, 95% CI: 3.826–10.067, P < 0.001) in the total cohort, RFS (HR=9.373, 95% CI: 2.724–32.245, P < 0.001) in the LG-NMIBC group, RFS rates (HR=6.873, 95% CI: 2.486–18.999, P < 0.001) in the HG-NMIBC group and RFS rates (HR=6.109, 95% CI: 2.847–13.109, P < 0.001) in the MIBC group. Conclusion The dynamic change of postoperative NLR is a potential marker for the early detection of bladder cancer recurrence. Patients with increased NLR after surgery tend to have higher risk of recurrence.

show abstract

Predictors of Residual T1 High Grade on Re-Transurethral Resection in a Large Multi-Institutional Cohort of Patients with Primary T1 High-Grade/Grade 3 Bladder Cancer

Cited by 29 publications

References 25 publications

Impact of systemic inflammatory markers on the response to Hyperthermic IntraVEsical Chemotherapy (HIVEC) in patients with non-muscle-invasive bladder cancer after bacillus Calmette–Guérin failure

Impact of systemic inflammatory markers on the response to Hyperthermic IntraVEsical Chemotherapy (HIVEC) in patients with non-muscle-invasive bladder cancer after bacillus Calmette–Guérin failure

Development and Validation of a Nomogram to Predict Lymph Node Metastasis in Patients With T1 High-Grade Urothelial Carcinoma of the Bladder

Clinical Value of Postoperative Neutrophil-to-Lymphocyte Ratio Change as a Detection Marker of Bladder Cancer Recurrence

Contact Info

Product

Resources

About