Predictors of Remission of T2DM and Metabolic Effects after Laparoscopic Roux-en-y Gastric Bypass in Obese Indian Diabetics—a 5-Year Study

Bhasker, Aparna Govil; Remedios, Carlyne; Batra, Payal; Sood, Amit; Shaikh, Shehla; Lakdawala, Muffazal

doi:10.1007/s11695-014-1501-x

Cited by 38 publications

(25 citation statements)

References 19 publications

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“…The present study revealed that C-peptide level was positively associated with diabetes remission after RYGB. This result is consistent with previous studies by Lee [19,29]. It is assumed that the elevated C-peptide levels in morbidly obese diabetic patients implicate well-preserved pancreatic β cell function capable enough to compensate for the increased insulin resistance.…”

Section: Discussionsupporting

confidence: 93%

“…Age, type 2 diabetes duration, insulin requirement, preoperative BMI, and FBG, HbA1c, and Cpeptide levels were analyzed as predictors in the previous studies [7,8,[17][18][19][20][21]. Some investigators have attempted to devise scoring systems to predict the probability of diabetes remission following RYGB; these include the ABCD score by Lee et al and the DiaRem score by Still et al [21,22].…”

Section: Discussionmentioning

confidence: 99%

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Prediction of Diabetes Remission in Morbidly Obese Patients After Roux-en-Y Gastric Bypass

Park

Kim

2015

OBES SURG

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Prediction of Diabetes Remission in Morbidly Obese Patients After Roux-en-Y Gastric Bypass

Park

Kim

2015

OBES SURG

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“… 47 A study on Asian Indians patients with diabetes of less than five years duration showed 100% diabetes remission after LRYGB. 48 Other benefits include improvement in hypertension, dyslipidemia, osteoarthritis, NAFLD and obstructive sleep apnea. 49 , 50 …”

Section: Introductionmentioning

confidence: 99%

Management of obesity in adult Asian Indians

Behl

Misra

2017

Indian Heart Journal

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The prevalence of obesity in India is increasing and ranges from 8% to 38% in rural and 13% to 50% in urban areas. Obesity is a risk factor for development of type 2 diabetes mellitus (T2DM), hypertension, dyslipidemia, coronary heart disease and many cancers. In Asian Indians excess abdominal and hepatic fat is associated with increased risk for T2DM and cardiovascular disease. There is higher risk for development of obesity related non-communicable diseases at lower body mass index levels, compared to white Caucasians. Despite being a commonly encountered medical problem, obesity poses challenges in treatment. Many Indian physicians find themselves to be lacking time and expertise to prepare an appropriate obesity management plan and patients experience continuous weight gain over time despite being under regular medical supervision. In this article, we outline approaches to obesity management in ‘real life mode’ and in context to Asian Indian patients.

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“…The surgical efficacy on diabetes resolution seems less prominent in the less or non-obese patients compared to the results from morbidly obese patients. )[9,14,[22][23][24][25][26][27][28]. The remission rate ranged from 24% to 84%according to the type of surgery and to the baseline characteristics of the patients as well.…”

mentioning

confidence: 99%

Prediction of Diabetes Remission after Bariatric or Metabolic Surgery

Park

2018

J Metab Bariatr Surg

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Bariatric surgery has evolved from the surgical measure to treat morbid obesity into the epochal remedy to treat metabolic syndrome as a whole, which is represented by type 2 diabetes. Numerous clinical trials have unanimously advocated bariatric or metabolic surgery over the non-surgical interventions, demonstrating markedly superior metabolic outcomes not only in morbidly obese patients who satisfy traditional criteria for bariatric surgery (body mass index [BMI] ＞35kg/m 2) but also in less obese or even in simply overweight patients. Nevertheless, not all the diabetic patients can achieve the most desirable outcomes, that is, diabetes remission, after metabolic surgery and candidates for metabolic surgery should be selected carefully based on the comprehensive preoperative assessment of the risk-benefit ratio. Predictors for diabetes remission after metabolic surgery can be largely classified into 2 groups based the mechanism of action; 1) indices for the preserved pancreatic beta-cell function, such as younger age, shorter duration of diabetes, and higher C-peptide level, and 2) those represent the potential reserve for reduction in insulin resistance, such as higher baseline BMI, and visceral fat area. Several prediction models for diabetes remission have been suggested by merging these predictors to guide clinicians and patients' joint decision-making process. Among them, 3 models, DiaRem, ABCD, and Individualized Metabolic Surgery (IMS) scores provide intuitive scoring systems which can be simply utilized in the routine clinical practice and have been validated in the independent external cohort. These prediction models need further validation in the various different ethnicities to ensure the universal applicability.

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Predictors of Remission of T2DM and Metabolic Effects after Laparoscopic Roux-en-y Gastric Bypass in Obese Indian Diabetics—a 5-Year Study

Cited by 38 publications

References 19 publications

Prediction of Diabetes Remission in Morbidly Obese Patients After Roux-en-Y Gastric Bypass

Prediction of Diabetes Remission in Morbidly Obese Patients After Roux-en-Y Gastric Bypass

Management of obesity in adult Asian Indians

Prediction of Diabetes Remission after Bariatric or Metabolic Surgery

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