Predictors of Relapse After Treatment for Methamphetamine Use

Ml, Brecht; C, von Mayrhauser; Anglin,

doi:10.1080/02791072.2000.10400231

Cited by 76 publications

(68 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8 The thalamic, but not the striatal deficits in relative activity, normalized after the first year. 9 Although the first weeks of abstinence from MA abuse are important for retention in treatment, 10 we know of no reports on cerebral metabolic changes during this period. Such effects might have important implications for therapies that involve specific brain circuits, and therefore are the subject of the present report.…”

Section: Introductionmentioning

confidence: 99%

Changes in cerebral glucose metabolism during early abstinence from chronic methamphetamine abuse

et al. 2007

View full text Add to dashboard Cite

Changes in brain function during the initial weeks of abstinence from chronic methamphetamine abuse may substantially affect clinical outcome, but are not well understood. We used positron emission tomography with [F-18]fluorodeoxyglucose (FDG) to quantify regional cerebral glucose metabolism, an index of brain function, during performance of a vigilance task. A total of 10 methamphetamine-dependent subjects were tested after 5-9 days of abstinence, and after 4 additional weeks of supervised abstinence. A total of 12 healthy control subjects were tested at corresponding times. Global glucose metabolism increased between tests (P = 0.01), more in methamphetamine-dependent (10.9%, P = 0.02) than control subjects (1.9%, NS). Glucose metabolism did not change in subcortical regions of methamphetaminedependent subjects, but increased in neocortex, with maximal increase ( > 20%) in parietal regions. Changes in reaction time and self-reports of negative affect varied more in methamphetamine-dependent than in control subjects, and correlated both with the increase in parietal glucose metabolism, and decrease in relative activity (after scaling to the global mean) in some regions. A robust relationship between change in self-reports of depressive symptoms and relative activity in the ventral striatum may have great relevance to treatment success because of the role of this region in drug abuse-related behaviors. Shifts in corticalsubcortical metabolic balance either reflect new processes that occur during early abstinence, or the unmasking of effects of chronic methamphetamine abuse that are obscured by suppression of cortical glucose metabolism that continues for at least 5-9 days after cessation of methamphetamine self-administration.

show abstract

Section: Introductionmentioning

confidence: 99%

Changes in cerebral glucose metabolism during early abstinence from chronic methamphetamine abuse

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Few studies have examined racial and ethnic differences in outcomes of individuals who abuse drugs other than narcotics, and most have found no significant racial or ethnic differences in alcohol, drug, legal, or psychiatric outcomes (3,4,12,22). The exceptions have been findings that compared with whites, Hispanics were more likely to have better family and social outcomes (3) and to have a shorter time to relapse following treatment for methamphetamine abuse (23). Also, in a study of drug offenders, African Americans had poorer employment outcomes compared with Hispanics and whites (12).…”

mentioning

confidence: 92%

Racial and Ethnic Differences in Substance Abuse Service Needs, Utilization, and Outcomes in California

Niv¹,

Pham²,

Hser³

2009

Psychiatric Services

View full text Add to dashboard Cite

Objective-This study examined differences in service needs and treatment utilization, retention, and outcomes between African-American, Hispanic, and white substance abusers in communitybased treatment programs.Methods-Data were collected from 2,401 African Americans, 3,222 Hispanics, and 7,980 whites who were admitted to 43 drug treatment programs across California from 2000 to 2001. The Addiction Severity Index (ASI) was administered at intake to assess clients' problem severity in a number of domains (alcohol use, drug use, employment, family and social relationships, legal, medical, and psychological), and treatment retention and arrest data were obtained from administrative records. A subsample was followed up at three months to assess service utilization (N=2,145) and again at nine months to readminister the ASI (N=2,566).Results-All three groups had similar severity levels of drug and legal problems upon treatment entry. Upon entry to treatment, white clients had the highest severity levels of alcohol, family, and psychiatric problems and African Americans had the highest severity levels of employment problems compared with the other two groups. Treatment retention did not differ between the three groups, but whites received a greater number of alcohol treatment services than did African Americans or Hispanics, and African Americans received a greater number of employment services than did Hispanic and white clients. All three groups showed significant improvement in all outcome domains except for medical outcomes. At the nine-month follow-up, whites had worse outcomes in the alcohol domain compared with the other two groups, and whites had worse outcomes in the legal domain compared with Hispanics. Compared with whites, African Americans were significantly less likely to be charged with driving under the influence in the year after treatment admission.Conclusions-All three groups improved after treatment, although benefits from treatment can be further enhanced if services underscore different facets of the psychosocial problems of each racial and ethnic group.Racial and ethnic disparities in the availability and quality of substance abuse treatment are of interest to both policy makers and treatment service providers. A number of studies have indicated greater unmet needs for health services and poorer health outcomes for persons from racial or ethnic minority groups across a range of disease areas, including cardiovascular disease, mental disorders, diabetes, and other chronic and infectious diseases (1). However, there has been little research on the service needs, utilization, and outcomes of African Americans and Hispanics in substance abuse treatment.The authors report no competing interests. Few studies have examined the service needs of persons from racial or ethnic minority groups in substance abuse treatment. Some studies have indicated that among persons in drug treatment, Hispanics have more severe substance use (2) and employment problems (2,3) than do African Americans or whites. Le...

show abstract

“…As Brechet et al argued, 50% of patients who stopped methamphetamine abuse experienced recurrence and came back to the cycle of addiction to this drug. This recurrence took place in 36% of cases during the first 6 months after withdrawal (14). Other research studies have highlighted physiological dependence and abuse craving as two important factors affecting relapse and return to the cycle of addiction among recovered individuals (15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

“…Reluctance to receive treatment could be due to the belief that treatment centers and their programs have been just for opioid-like substance abusers and they have given no help in terms of changes and treatments in their abuse manner (18,19). Deficiencies in the management of withdrawal symptoms during treatment may cause a lot people abandon treatment on the first few days or weeks after withdrawal (14). A better understanding of the natural process and the symptoms of methamphetamine withdrawal can help in preventing its recurrence (20,21).…”

Section: Introductionmentioning

confidence: 99%

Investigating the Trend and Severity of Withdrawal Symptoms in Methamphetamine Users Amongst Homeless Addicts

Khani

Barati

Mollajan

et al. 2018

Int J High Risk Behav Addict

View full text Add to dashboard Cite

Background and Objectives: Determining the trend and severity of withdrawal symptoms is considered as the first stage of addiction treatment. Therefore, the purpose of this study was to investigate the trend and severity of withdrawal symptoms in methamphetamine (meth) addicts. Methods: This cross-sectional study was conducted on all the clients admitted to quit methamphetamine abuse in a residential treatment center for homeless addicts in Alborz province in 2014. According to the average daily intake, the clients were divided into two groups: mild and severe. To collect the data for this study; methamphetamine withdrawal symptoms assessment scale, Beck depression inventory, and a demographic information questionnaire were used. The analysis of variance (ANOVA) was employed for repeated measures through the SPSS software version 16 and at a significance level of 0.05. Results:The findings showed that methamphetamine withdrawal symptoms including anxiety, abuse craving, and fatigue in the first 24 hours and the first, the second, and the third weeks as well as the symptoms of depression within three weeks after the withdrawal began to decline significantly (P < 0.0001). Following the analysis of variance (ANOVA) for repeated data and taking addiction severity index into account, it was observed that the difference between the two groups of mild and severe addicts was significant in terms of the trend and severity of methamphetamine withdrawal symptoms (P < 0.0001). Conclusions:The hardest stage to quit methamphetamine addiction was the first 24 hours after withdrawal with a downward trend; however, abuse craving especially in severe addicted group persisted even after the third week of withdrawal which could be a risk factor for recurrence and re-abuse. Thus, it was suggested that therapists were required to pay more attention to this issue in the treatment of this group of addicted individuals.

show abstract

Predictors of Relapse After Treatment for Methamphetamine Use

Cited by 76 publications

References 20 publications

Changes in cerebral glucose metabolism during early abstinence from chronic methamphetamine abuse

Changes in cerebral glucose metabolism during early abstinence from chronic methamphetamine abuse

Racial and Ethnic Differences in Substance Abuse Service Needs, Utilization, and Outcomes in California

Investigating the Trend and Severity of Withdrawal Symptoms in Methamphetamine Users Amongst Homeless Addicts

Contact Info

Product

Resources

About