Predictors of Refractory Macular Edema After Branch Retinal Vein Occlusion Following Intravitreal Bevacizumab

Moon, Byung Gil; Cho, Ah Ran; Kim, You Na; Kim, June-Gone

doi:10.1097/iae.0000000000001674

Cited by 31 publications

(30 citation statements)

References 40 publications

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“…Alternative or additional pathways may contribute to visual outcomes. Previous studies regarding visual outcomes have focused on the outer layers of the retina, such as the ELM, EZ, and IZ [15][16][17][18]20]. In contrast, there were no significant differences between the recurrence of macular edema and the incidences of ELM or EZ disruption in the current study.…”

Section: Discussioncontrasting

confidence: 82%

“…In contrast, sectional images of the retina can easily be obtained using OCT. In this regard, previous reports have focused on findings from the external limiting membrane (ELM), ellipsoid zone (EZ), and interdigitation zone (IZ) as predictors of visual outcome after macular edema due to BRVO [15][16][17][18]. However, the predictive factors for recurrences have remained unclear.…”

Section: Introductionmentioning

confidence: 99%

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Predicting recurrences of macular edema due to branch retinal vein occlusion during anti-vascular endothelial growth factor therapy

Suzuki

Nagai

Minami

et al. 2019

Graefes Arch Clin Exp Ophthalmol

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Section: Discussioncontrasting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Predicting recurrences of macular edema due to branch retinal vein occlusion during anti-vascular endothelial growth factor therapy

Suzuki

Nagai

Minami

et al. 2019

Graefes Arch Clin Exp Ophthalmol

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“…In previous studies, a short distance of occlusion from the disc margin was found to be associated with increased retinal hemorrhage and development of refractory macular edema. [ 31 32 ] Although it was expected that there would be more congestion and ischemic areas in occlusions located close to the vascular root, the FAZ area and visual acuity were not associated with the optic disc-affected AV crossing distance. However, the vessel density was greater in the superficial and deep plexuses of the unaffected macular hemifield when the optic disc-affected AV crossing distance was smaller.…”

Section: Discussionmentioning

confidence: 99%

Microvascular and functional changes according to the fundus location of the affected arteriovenous crossing in patients with branch retinal vein occlusion

Arslan

Güven

Demir

et al. 2021

Indian Journal of Ophthalmology

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Purpose: The aim of this study was to evaluate the structural and functional changes occurring in patients with branch retinal vein occlusion (BRVO) according to the distance of the affected arteriovenous (AV) crossing to the centers of the fovea and optic disc by optic coherence tomography angiography (OCTA). Methods: Forty-five patients with unilateral BRVO and 45 age- and sex-matched healthy controls were included in this retrospective observational study. Images of the macula (3 mm × 3 mm) and affected AV crossing sites were obtained by OCTA. The fovea-AV crossing distance (FAVD), optic disc-AV crossing distance (DAVD), and optic disc-fovea distance (DFD) were measured. Results: The FAVD/DFD ratio was positively correlated with the vessel density in the superficial and deep affected hemifields ( r = 0.430, P < 0.05 and r = 0.308, P < 0.05, respectively) and negatively correlated with the superficial foveal avascular zone and logarithm of the minimum angle of resolution (logMAR) visual acuity ( r = –0.412, P < 0.05 and r = –0.356, P < 0.05, respectively). The DAVD/DFD ratio was not correlated with the logMAR visual acuity, superficial FAZ area or vessel densities in the affected hemifield (all P > 0.05). Conclusion: The affected AV crossing site that was further away from the fovea had better visual acuity and quantitative microvascular parameters in the affected hemifields. However, this correlation was not observed for the distance between the affected AV crossing site and the optic disc.

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“…These events increase vascular endothelial growth factor (VEGF) secretion and increase vascular permeability and thus cause macular edema (2,3). Macular edema is the most common cause of visual loss in BRVO (4,5). Laser photocoagulation, intravitreal steroid injection and intravitreal anti-VEGF injection are used for the treatment of macular edema (6,7).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Pre-treatment Intraretinal Cyst Diameter on Visual and Anatomical Outcomes after Intravitreal Ranibizumab Treatment in Cystoid Macular Edema Secondary to Branch Retinal Vein Occlusion

Bayat¹,

Çakir²,

Bölükbaşı³

et al. 2019

eamr

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To investigate the effect of the largest intraretinal cyst diameter in the macula on visual and anatomical outcomes after intravitreal ranibizumab (IVR) treatment in cystoid macular edema (CME) secondary to branch retinal vein occlusion (BRVO). Methods: Forty-two eyes of 42 patients who underwent IVR treatment for CME secondary to BRVO were studied retrospectively. Patients were evaluated after three-monthly IVR injection. The pre-treatment and post-treatment spectral domain optical coherence tomography parameters and best-corrected visual acuity (BCVA) were recorded. The effect of pre-treatment intraretinal cyst diameter on post-treatment central macular thickness (CMT) and BCVA was investigated. Results: There were 27 (64.3%) men and 15 (35.7%) women in the study. The mean age was 59.5±9.6 years. The mean pre-treatment CMT was 485±160 µm and the mean pre-treatment BCVA was 0.84±0.55 logMAR. After 3 doses of IVR, CMT gain was 201±168 µm and BCVA gain was 0.41±0.43 logMAR. The mean pre-treatment cyst diameter was 241±121 µm. Although there was a low degree positive correlation between pre-treatment cyst diameter and CMT gain, this correlation was not statistically significant (r=0.245, p=0.059). Although there was a low degree negative correlation between pre-treatment cyst diameter and BCVA, this correlation was not statistically significant (r=-0.145, p=0.184). Conclusion: There was no statistically significant correlation between pre-treatment cyst diameter and CMT and BCVA gain in CME treatment secondary to BRVO.

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Predictors of Refractory Macular Edema After Branch Retinal Vein Occlusion Following Intravitreal Bevacizumab

Abstract: If BRVO-ME patients exhibit the above-mentioned characteristics, they may have refractory ME, which should inform treatment decisions.

Cited by 31 publications

References 40 publications

Predicting recurrences of macular edema due to branch retinal vein occlusion during anti-vascular endothelial growth factor therapy

Predicting recurrences of macular edema due to branch retinal vein occlusion during anti-vascular endothelial growth factor therapy

Microvascular and functional changes according to the fundus location of the affected arteriovenous crossing in patients with branch retinal vein occlusion

The Effect of Pre-treatment Intraretinal Cyst Diameter on Visual and Anatomical Outcomes after Intravitreal Ranibizumab Treatment in Cystoid Macular Edema Secondary to Branch Retinal Vein Occlusion

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