Predictors of quality of life in young adults with congenital heart disease

Rometsch, Sarah; Greutmann, Matthias; Latal, Beatrice; Bernaschina, Ivana; Knirsch, Walter; Schaefer, Christina; Oxenius, Angela; Landolt, Markus A.

doi:10.1093/ehjqcco/qcy046

Cited by 25 publications

(27 citation statements)

References 26 publications

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“…The lack of correlation between other medical variables such as cyanosis, age or number of the surgeries and SHS or PeQoL has also been reported elsewhere. [44][45][46] The present study, however, found scoliosis to be the only medical parameter associated with poor quality of life. This finding seems logical because a significant scoliosis can potentially alter the respiratory capacity and thus the physical performance of the patient, and also negatively influence the patient's psychological approach to his (her) self-image.…”

Section: Discussioncontrasting

confidence: 69%

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Quality of life of adult Fontan patients

et al. 2020

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Background: Progress in the management of complex congenital heart disease (CHD) led to an improvement in survival rates of adults with a Fontan-like circulation. The objective of this study was to assess the subjective health status and quality of life of this population. Methods and results: Patients aged more than 18 years at the time of the study, who underwent a Fontan-like procedure. Subjective health status was assessed by the SF-36 questionnaire and a linear analog scale was used to score patients’ self-perception of their quality of life; cardiac and demographic parameters were collected. Results: Among 65 eligible patients, 60 (23 females; mean ± SD age: 25.7 ± 7.2 years) answered the SF-36 questionnaire and 46 of these were interviewed to evaluate their perceived quality of life. Among them, 20 (33.3%) were working full-time and 21 (35%) experienced arrhythmias. The physical SF-36 scores were lower in patients than in the general population (p ≤ 0.05). The New York Hear Association (NYHA) class and occupation were correlated with SF-36 scores of physical activity (respectively, p = 0.0001 and p = 0.025). SF-36 scores of psychological status were associated with the number of drugs and occupation (respectively, p = 0.0001 and p = 0.02). The mean ± SD quality of life score measured using a linear analog scale was 7.02 ± 1.6 and was linked to education and occupation (p ≤ 0.05) but not with cardiac parameters. Conclusion: Adult Fontan patients perceive an impaired physical health but report a good overall quality of life. Education and occupation impacts significantly on Fontan patients’ quality of life.

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Section: Discussioncontrasting

confidence: 69%

“…The NYHA class correlated significantly with the subjective physical health (SF-36) as previously reported. 29,44 NYHA has been controversially associated with the level of QoL. The lack of correlation between other medical variables such as cyanosis, age or number of the surgeries and SHS or PeQoL has also been reported elsewhere.…”

Section: Discussionmentioning

confidence: 99%

Quality of life of adult Fontan patients

et al. 2020

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“…Patients with congenital heart disease and healthy controls were recruited from a previous study on health-related quality of life in young adults with congenital heart diseases conducted in 2015 [12]. In short, 300 patients between 18 and 30 years of age without severe neurological impairments, comorbid genetic syndromes, severe psychiatric diagnoses and who were fluent in German were eligible for the study in 2015 and were approached when attending the cardiac outpatient clinic at the University Hospital Zurich, Switzerland.…”

Section: Study Design and Samplementioning

confidence: 99%

Impact of the COVID-19 Pandemic on Health-Related Concerns, Quality of Life and Psychological Adjustment in Young Adults with Congenital Heart Disease

Wehrle¹,

Landolt²,

Latal³

et al. 2020

Congenital Heart Disease

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Background: The risk for a severe disease course in case of infection with SARS-CoV-2 in young adults with congenital heart disease is largely unknown, potentially leading to uncertainty and anxiety among affected patients. This study aims to investigate health-related concerns, health-related quality of life and psychological adjustment in patients with congenital heart disease compared to healthy peers during the COVID-19 pandemic. Methods: One-hundred patients with congenital heart disease and 50 controls (M = 29.7, SD = 3.8 years) were recruited. They completed an online survey including the assessment of health-related concerns regarding COVID-19, the 12-item Short Form Health Survey and the Brief Symptom Inventory. Results: Patients considered COVID-19 to be a more serious issue (Generalized odds ratio [GenOR] = 1.67, p = 0.04), were more concerned about becoming infected (GenOR = 2.93, p < 0.001) and expressed more fear about leaving their homes (GenOR = 1.81, p = 0.004) while general anxiety symptoms were not different between groups (p = 0.23). Patients relied more on family and friends for support (30% vs. 2% in controls, p < 0.001) and reported better compliance with protective measures (p = 0.03). Mental health-related quality of life and psychological adjustment were not different between groups (p = 0.17 and p = 0.68, respectively). Physical health-related quality of life was lower in patients compared to controls (p = 0.03). Conclusions: Young adults with congenital heart disease in Switzerland are more concerned about their health during the COVID-19 pandemic compared to healthy peers. These concerns, however, do not translate into generally impaired mental wellbeing. The impact of the easing of lockdown measures on long-term anxiety levels and quality of life requires further study

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“…There is often variability in HRQoL between individuals and across time; hence, longitudinal designs are useful for understanding the variability of HRQoL trajectories and the factors associated with these trajectories. The paucity of longitudinal HRQoL data for patients with AMI11 limits the comprehensive evaluation of the burden of AMI, as well its appraisal as a potential study endpoint. The Evaluation of the Methods and Management of Acute Coronary Events (EMMACE)-3 and EMMACE-412 national longitudinal cohort studies collected data concerning AMI, comorbidities, treatments, clinical outcomes and HRQoL for patients with AMI in 77 hospitals in England between 2011 and 2015.…”

Section: Introductionmentioning

confidence: 99%

Quality of life trajectories in survivors of acute myocardial infarction: a national longitudinal study

Munyombwe

Hall

Dondo

et al. 2019

Heart

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AimTo define trajectories of perceived health-related quality of life (HRQoL) among survivors of acute myocardial infarction (AMI) and identify factors associated with trajectories.MethodsData on HRQoL among 9566 survivors of AMI were collected from 77 National Health Service hospitals in England between 1 November 2011 and 24 June 2015. Longitudinal HRQoL was collected using the EuroQol five-dimension questionnaire measured at hospitalisation, 1, 6 and 12 months post-AMI. Trajectories of perceived HRQoL post-MI were determined using multilevel regression analysis and latent class growth analysis (LCGA).ResultsOne or more percieved health problems in mobility, self-care, usual activities, pain/discomfort and anxiety/depression was reported by 69.1% (6607/9566) at hospitalisation and 59.7% (3011/5047) at 12 months. Reduced HRQoL was associated with women (−4.07, 95% CI −4.88 to −3.25), diabetes (−2.87, 95% CI −3.87 to −1.88), previous AMI (−1.60, 95% CI −2.72 to −0.48), previous angina (−1.72, 95% CI −2.77 to −0.67), chronic renal failure (−2.96, 95% CI −5.08 to −0.84; −3.10, 95% CI −5.72 to −0.49), chronic obstructive pulmonary disease (−3.89, 95% CI −5.07 to −2.72) and cerebrovascular disease (−2.60, 95% CI −4.24 to −0.96). LCGA identified three subgroups of HRQoL which we labelled: improvers (68.1%), non-improvers (22.1%) and dis-improvers (9.8%). Non-improvers and dis-improvers were more likely to be women, non-ST-elevation myocardial infarction (NSTEMI) and have long-term health conditions, compared with improvers.ConclusionsQuality of life improves for the majority of survivors of AMI but is significantly worse and more likely to decline for women, NSTEMI and those with long-term health conditions. Assessing HRQoL both in hospital and postdischarge may be important in determining which patients could benefit from tailored interventions.Trial registrationNCT01808027 and NCT01819103.

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Predictors of quality of life in young adults with congenital heart disease

Cited by 25 publications

References 26 publications

Quality of life of adult Fontan patients

Quality of life of adult Fontan patients

Impact of the COVID-19 Pandemic on Health-Related Concerns, Quality of Life and Psychological Adjustment in Young Adults with Congenital Heart Disease

Quality of life trajectories in survivors of acute myocardial infarction: a national longitudinal study

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