Predictors of quality of life ratings for persons with dementia simultaneously reported by patients and their caregivers: the Cache County (Utah) Study

Buckley, Trevor; Fauth, Elizabeth B.; Morrison, Ann; Tschanz, JoAnn T.; Rabins, Peter V.; Piercy, Kathleen W.; Norton, Maria C.; Lyketsos, Constantine G.

doi:10.1017/s1041610212000063

Cited by 49 publications

(71 citation statements)

References 27 publications

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“…The differences in the rating of QOL between self-report and proxy report generally depend on variables such as depressive symptoms and severity of dementia and should be recognized [55,61,62,63,64]. The QUALIDEM was developed to measure QOL in persons with dementia; however, observational instruments always have the possibility of observer bias [65].…”

Section: Discussionmentioning

confidence: 99%

Characteristics Associated with Quality of Life in Long-Term Care Residents with Dementia: A Cross-Sectional Study

Klapwijk

Caljouw

Pieper

et al. 2016

Dement Geriatr Cogn Disord

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Background: To determine which characteristics are associated with quality of life (QOL) in residents with moderate to very severe dementia in long-term care facilities (LTCFs). Material and Methods: This was a cross-sectional analysis of a cluster randomized controlled study in 12 Dutch LTCFs that enrolled 288 residents, with moderate to severe dementia assessed with the Reisberg Global Deterioration Scale (Reisberg GDS) and QOL with the QUALIDEM. Characteristics that were hypothesized to be associated with the six domains of QOL (applicable to very severe dementia) included demographic variables, activities of daily living (Katz ADL), cognitive performance (Cognitive Performance Scale; CPS), pain (Pain Assessment Checklist for Seniors with Limited Ability to Communicate; PACSLAC-D), neuropsychiatric symptoms (Neuropsychiatric Inventory-Nursing Home Version; NPI-NH) and comorbidities. Results: Multivariate logistic regression modelling showed associations with age in the domain Social isolation [odds ratio, OR, 0.95 (95% confidence interval, CI, 0.91-0.99)], ADL level in the domain Positive affect [OR 0.89 (95% CI 0.83-0.95)] and the domain Social relations [OR 0.87 (95% CI 0.81-0.93)], severity of dementia in the domain Social relations [OR 0.28 (95% CI 0.12-0.62)] and in the domain Social isolation [OR 2.10 (95% CI 1.17-3.78)], psychiatric disorders in the domain Positive affect [OR 0.39 (95% CI 0.17-0.87)] and pulmonary diseases in the domain Negative affect [OR 0.14 (95% CI 0.03-0.61)] of the QUALIDEM. Neuropsychiatric symptoms were independently associated with all six domains of the QUALIDEM [OR 0.93 (95% CI 0.90-0.96) to OR 0.97 (95% CI 0.95-0.99)]. Pain was associated with the domains Care relationship [OR 0.92 (95% CI 0.84-1.00)] and Negative affect [OR 0.92 (95% CI 0.85-1.00)]. Conclusion: QOL in dementia is independently associated with age, ADL, dementia severity, pain, psychiatric disorders, pulmonary diseases and neuropsychiatric symptoms. It is possible to detect persons with dementia at risk for a lower QOL. This information is important for developing personalized interventions to improve QOL in persons with dementia in LTCFs.

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Section: Discussionmentioning

confidence: 99%

Characteristics Associated with Quality of Life in Long-Term Care Residents with Dementia: A Cross-Sectional Study

Klapwijk

Caljouw

Pieper

et al. 2016

Dement Geriatr Cogn Disord

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“…The burden of Alzheimer’s disease (AD) is compounded by neuropsychiatric symptoms (NPS) which occur in almost all patients [1, 2], and are usually persistent [3], NPS are associated with accelerated cognitive and functional decline [4, 5], worse quality of life [6, 7], earlier institutionalization [8–10], and accelerated mortality [10, 11]. Depression, apathy, anxiety, agitation and irritability are the most commonly observed NPS [2, 12].…”

Section: Introductionmentioning

confidence: 99%

Latent Classes of Neuropsychiatric Symptoms in NACC Controls and Conversion to Mild Cognitive Impairment or Dementia

Leoutsakos

Forrester

Lyketsos

et al. 2015

JAD

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Background A number of studies have linked neuropsychiatric symptoms to increase risk of dementia. Objective To determine if risk of conversion to mild cognitive impairment or dementia among healthy controls varied as a function of their pattern of neuropsychiatric symptoms. Method We studied individuals in the National Alzheimer Coordinating Center dataset collected from 34 Alzheimer Disease Centers between 2005 and 2013. The analysis included 4,517 volunteers who were ≥ 60 years old, cognitively normal, and had complete Neuropsychiatric Inventory data at their baseline visit, and had at least one follow-up. We used latent class analysis to identify 4 classes based on patterns of NPI symptoms. We used a cox proportional hazards model to determine if time to MCI or dementia varied by baseline latent class membership. Results We identified 4 latent classes of neuropsychiatric symptoms: irritable, depressed, complex (depression, apathy, irritability and nighttime behaviors) and asymptomatic. 873 participants converted to MCI or dementia. Hazard ratios for conversion by class were 1.76 (95% CI: 1.34, 2.33) for the irritable class, 3.20 (95% CI: 2.24, 4.58) for the complex class, and 1.90 (95% CI: 1.49, 2.43) for the depressed class, with the asymptomatic class as the reference. Conclusions Membership in all 3 symptomatic classes was associated with greater risk of conversion to MCI or dementia; the complex class had the greatest risk. Different patterns of neuropsychiatric symptoms may represent different underlying neuropathological pathways to dementia. Further work imaging and pathology research is necessary to determine if this is the case.

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“…11 Moving to a care facility means to leave a known and familiar environment for an unfamiliar one, 12 and therefore the main challenge in residential care facilities is to create appropriate and supportive living environments that contribute to the QoL of older adults. 14 Previous research has shown the important role that cognitive performance 15 and loss of independence 16 has on the QoL of older adults with dementia, as well as the important negative effect of depression. theater, occupational therapy).…”

Section: Introductionmentioning

confidence: 99%

Quality of life in older people with dementia: A multilevel study of individual attributes and residential care center characteristics

Marventano

Flores

Sanz-Barbero

et al. 2014

Geriatrics Gerontology Int

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Predictors of quality of life ratings for persons with dementia simultaneously reported by patients and their caregivers: the Cache County (Utah) Study

Cited by 49 publications

References 27 publications

Characteristics Associated with Quality of Life in Long-Term Care Residents with Dementia: A Cross-Sectional Study

Characteristics Associated with Quality of Life in Long-Term Care Residents with Dementia: A Cross-Sectional Study

Latent Classes of Neuropsychiatric Symptoms in NACC Controls and Conversion to Mild Cognitive Impairment or Dementia

Quality of life in older people with dementia: A multilevel study of individual attributes and residential care center characteristics

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