Predictors of Pseudophakic Retinal Tears at a Tertiary Care Academic Medical Center

Fonteh, Cheryl N; Patnaik, Jennifer L; Grove, Nathan; Lynch, Anne M.; Christopher, Karen L

doi:10.1016/j.oret.2022.01.010

Cited by 4 publications

(1 citation statement)

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“…Ocular axial length (AL) is an eye dimension that refers to the distance (in millimeters) from the apex of the anterior corneal (front of the eye) to the retina. AL elongation is a feature of myopia, which is the most common form of refractive error, and several other eye diseases such as retinal tear, retinal detachment, inherited retinal diseases, glaucoma, and myopic macular degeneration ( Adams, 1987 ; Grosvenor, 1988 ; Arias et al, 2015 ; Tideman et al, 2016 ; Tideman et al, 2018 ; Streho et al, 2019 ; Rezapour et al, 2021 ; Fonteh et al, 2022 ; Foo et al, 2022 ; Omodaka et al, 2022 ; Williams et al, 2022 ; Xu et al, 2022 ). Moreover, the measurement of AL is generally more precise and reproducible than assessments of refractive/myopia status ( Mu et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

A multiethnic genome-wide analysis of 19,420 individuals identifies novel loci associated with axial length and shared genetic influences with refractive error and myopia

Jiang¹,

Melles²,

Yin³

et al. 2023

Front. Genet.

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Introduction: Long axial length (AL) is a risk factor for myopia. Although family studies indicate that AL has an important genetic component with heritability estimates up to 0.94, there have been few reports of AL-associated loci.Methods: Here, we conducted a multiethnic genome-wide association study (GWAS) of AL in 19,420 adults of European, Latino, Asian, and African ancestry from the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort, with replication in a subset of the Consortium for Refractive Error and Myopia (CREAM) cohorts of European or Asian ancestry. We further examined the effect of the identified loci on the mean spherical equivalent (MSE) within the GERA cohort. We also performed genome-wide genetic correlation analyses to quantify the genetic overlap between AL and MSE or myopia risk in the GERA European ancestry sample.Results: Our multiethnic GWA analysis of AL identified a total of 16 genomic loci, of which 5 are novel. We found that all AL-associated loci were significantly associated with MSE after Bonferroni correction. We also found that AL was genetically correlated with MSE (rg = −0.83; SE, 0.04; p = 1.95 × 10−89) and myopia (rg = 0.80; SE, 0.05; p = 2.84 × 10−55). Finally, we estimated the array heritability for AL in the GERA European ancestry sample using LD score regression, and found an overall heritability estimate of 0.37 (s.e. = 0.04).Discussion: In this large and multiethnic study, we identified novel loci, associated with AL at a genome-wide significance level, increasing substantially our understanding of the etiology of AL variation. Our results also demonstrate an association between AL-associated loci and MSE and a shared genetic basis between AL and myopia risk.

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