Predictors of Progression of Recently Diagnosed Atrial Fibrillation in REgistry on Cardiac Rhythm DisORDers Assessing the Control of Atrial Fibrillation (RecordAF)–United States Cohort

Zhang, Yuanyuan; Qiu, Chunfu; Davis, Pamela J.; Jhaveri, Mehul; Prystowsky, Eric N.; Kowey, Peter R.; Weintraub, William S.

doi:10.1016/j.amjcard.2013.02.056

Cited by 48 publications

(36 citation statements)

References 25 publications

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“…The observed rate of progression in the current analysis (23% over an 18-month period) is consistent with similar, but smaller studies, which consistently have shown progression rates of about 14–18% at 1 year. 6 8 9 The one notable exception is the Canadian Registry of Atrial Fibrillation (CARAF), which enrolled 757 patients with paroxysmal AF. 4 The progression rate to chronic AF (defined as ECG documentation of AF on two consecutive ECGs at least a week apart) was only 8.6% during the first year, although a slow but steady increase was observed thereafter (about 25% at 5 years).…”

Section: Discussionmentioning

confidence: 99%

Heart rate is associated with progression of atrial fibrillation, independent of rhythm

Holmqvist

Kim

Steinberg

et al. 2015

Heart

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ObjectiveAtrial fibrillation (AF) often progresses from paroxysmal or persistent to more sustained forms, but the rate and predictors of AF progression in clinical practice are not well described.MethodsUsing the Outcomes Registry for Better Informed Treatment of AF, we analysed the incidence and predictors of progression and tested the discrimination and calibration of the HATCH (hypertension, age, TIA/stroke, chronic obstructive pulmonary disease, heart failure) and CHA2DS2VASc scores for identifying AF progression.ResultsAmong 6235 patients with paroxysmal or persistent AF at baseline, 1479 progressed, during follow-up (median 18 (IQR 12–24) months). These patients were older and had more comorbidities than patients who did not progress (CHADS2 2.3±1.3 vs 2.1±1.3, p<0.0001). At baseline, patients with AF progression were more often on a rate control as opposed to a rhythm control strategy (66 vs 56%, p<0.0001) and had higher heart rate (72(64–80) vs 68(60–76) bpm, p<0.0001). The strongest predictors of AF progression were AF on the baseline ECG (OR 2.30, 95% CI 1.95 to 2.73, p<0.0001) and increasing age (OR 1.16, 95% CI1.09 to 1.24, p<0.0001, per 10 increase), while patients with lower heart rate (OR 0.84, 95% CI 0.79 to 0.89, p<0.0001, per 10 decrease ≤80) were less likely to progress. There was no significant interaction between rhythm on baseline ECG and heart rate (p=0.71). The HATCH and CHA2DS2VASc scores had modest discriminatory power for AF progression (C-indices 0.55 (95% CI 0.53 to 0.58) and 0.55 (95% CI 0.52 to 0.57)).ConclusionsWithin 1.5 years, almost a quarter of the patients with paroxysmal or persistent AF progress to a more sustained form. Progression is strongly associated with heart rate, and age.

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Section: Discussionmentioning

confidence: 99%

Heart rate is associated with progression of atrial fibrillation, independent of rhythm

Holmqvist

Kim

Steinberg

et al. 2015

Heart

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“…Although AF remains paroxysmal for the majority of patients (42,43), sustained forms of AF are associated with more severe complications and poorer prognoses. Prevention of AF progression could lead to a substantial reduction in AF-related complications.…”

Section: Discussionmentioning

confidence: 99%

Dietary Fat Intake Is Differentially Associated with Risk of Paroxysmal Compared with Sustained Atrial Fibrillation in Women

Chiuve

Sandhu

Moorthy

et al. 2015

The Journal of Nutrition

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“…18 Progression in AF type was considered as a binary outcome (either "the same/better" or "worsening"); worsening was defined as (1) paroxysmal AF at baseline (or "first detected/new onset" AF becoming paroxysmal AF at next available follow-up) becoming persistent or permanent at the last follow-up visit or (2) persistent AF at baseline (or "first detected/new onset" AF becoming persistent AF at next available follow-up) becoming permanent at the last follow-up visit. 19 The baseline ORBIT-AF population included 10,132 patients enrolled between June 2010 and August 2011 from 176 sites. Data on CPAP treatment were lacking in 4 patients, yielding a study population of 1,837 patients with OSA for the analyses regarding CPAP.…”

Section: Methodsmentioning

confidence: 99%

Impact of obstructive sleep apnea and continuous positive airway pressure therapy on outcomes in patients with atrial fibrillation—Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF)

Holmqvist¹,

Guan²,

Zhu³

et al. 2015

American Heart Journal

198

136

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Predictors of Progression of Recently Diagnosed Atrial Fibrillation in REgistry on Cardiac Rhythm DisORDers Assessing the Control of Atrial Fibrillation (RecordAF)–United States Cohort

Cited by 48 publications

References 25 publications

Heart rate is associated with progression of atrial fibrillation, independent of rhythm

Heart rate is associated with progression of atrial fibrillation, independent of rhythm

Dietary Fat Intake Is Differentially Associated with Risk of Paroxysmal Compared with Sustained Atrial Fibrillation in Women

Impact of obstructive sleep apnea and continuous positive airway pressure therapy on outcomes in patients with atrial fibrillation—Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF)

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