Predictors of Progression and Mortality in Patients with Chronic Hypersensitivity Pneumonitis: Retrospective Analysis of Registry of Fibrosing Interstitial Lung Diseases

Trushenko, Natalia V.; Suvorova, O. N.; Першина, Е. С.; Nekludova, Galina; Чикина, С. Ю.; Levina, Iuliia A.; Chernyaev, A. L.; Самсонова, М. В.; Tyurin, I. E.; Mustafina, Malika; Yaroshetskiy, Andrey I.; Nadtochii, N.B.; Merzhoeva, Zamira M.; Proshkina, A A; Avdeev, S. N.

doi:10.3390/life13020467

Cited by 5 publications

(3 citation statements)

References 36 publications

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“…In the literature, several studies show a large proportion of cases diagnosed as HP with no apparent exposure to antigens. 31 In contrast, in our study, 53% of the total number of patients with ILDs displayed potential exposures to HP-related antigens. However, the number of patients with a final diagnosis of HP in this group was only 44%.…”

Section: Discussioncontrasting

confidence: 77%

“…(30) Na literatura, vários estudos mostram uma grande proporção de casos diagnosticados como PH sem exposição aparente a antígenos. (31) Por outro lado, em nosso estudo, 53% do número total de pacientes com DPI apresentaram potencial exposição a antígenos para PH. No entanto, o número de pacientes com diagnóstico final de PH nesse grupo foi de apenas 44%.…”

Section: /7unclassified

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Relative incidence of interstitial lung diseases in Brazil

Lobo Krupok Matias1,

Alberto de Castro Pereira1,

Raquel Soares1

et al. 2024

J Bras Pneumol.

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Objective: To assess the relative frequency of incident cases of interstitial lung diseases (ILDs) in Brazil. Methods: This was a retrospective survey of new cases of ILD in six referral centers between January of 2013 and January of 2020. The diagnosis of ILD followed the criteria suggested by international bodies or was made through multidisciplinary discussion (MDD). The condition was characterized as unclassifiable ILD when there was no specific final diagnosis following MDD or when there was disagreement between clinical, radiological, or histological data. Results: The sample comprised 1,406 patients (mean age = 61 ± 14 years), and 764 (54%) were female. Of the 747 cases exposed to hypersensitivity pneumonitis (HP)-related antigens, 327 (44%) had a final diagnosis of HP. A family history of ILD was reported in 8% of cases. HRCT findings were indicative of fibrosis in 74% of cases, including honeycombing, in 21%. Relevant autoantibodies were detected in 33% of cases. Transbronchial biopsy was performed in 23% of patients, and surgical lung biopsy, in 17%. The final diagnoses were: connective tissue disease-associated ILD (in 27%), HP (in 23%), idiopathic pulmonary fibrosis (in 14%), unclassifiable ILD (in 10%), and sarcoidosis (in 6%). Diagnoses varied significantly among centers (?2 = 312.4; p < 0.001). Conclusions: Our findings show that connective tissue disease-associated ILD is the most common ILD in Brazil, followed by HP. These results highlight the need for close collaboration between pulmonologists and rheumatologists, the importance of detailed questioning of patients in regard with potential exposure to antigens, and the need for public health campaigns to stress the importance of avoiding such exposure.

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Section: Discussioncontrasting

confidence: 77%

Section: /7unclassified

Relative incidence of interstitial lung diseases in Brazil

Lobo Krupok Matias1,

Alberto de Castro Pereira1,

Raquel Soares1

et al. 2024

J Bras Pneumol.

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“…SpO 2 is an important physiological variable measured during exercise tests. It carries high prognostic importance in different ILDs and is predictor of mortality in IPF patients ( Imamura et al, 2023 ; Lama et al, 2003 ; Trushenko et al, 2023 ). In the present study, nadir SpO 2 during 6MWT and 1-STST showed good agreement (ICC=0.86; 0.77–0.92) and a strong correlation ( r =0.76, P <0.001).…”

Section: Discussionmentioning

confidence: 99%

Assessment of the feasibility of 1-min sit-to-stand test in evaluating functional exercise capacity in interstitial lung disease patients

Singh,

Aggarwal,

Dutta

et al. 2023

J Exerc Rehabil

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Six-min walk test (6MWT) is widely used exercise test for the evaluation of interstitial lung disease (ILD). However, the long test duration and need for long and flat surface hinder its routine use. One-min sit-to-stand test (1-STST) is devoid of such limitations, but has been scarcely evaluated. The study was conducted to evaluate the performance of 1-STST by correlating it with 6MWT in ILD patients. Stable ILD patients were prospectively enrolled. After initial spirometry, all patients performed 6MWT and 1-STST following the standard recommendations. Exercise capacity and physiological parameters (heart rate, pulse oxygen saturation, blood pressure and dyspnea [modified Borg scale]) including peripheral oxygen saturation (SpO2) were correlated after the tests using Pearson correlation, Intraclass correlation coefficient (ICC) and kappa (κ) coefficient. The results showed that the mean age of the patients (n= 60) was 58.8± 11.5 years (male:female= 1:1). Repetitions after 1-STST showed significant correlation with 6MWT (r = 0.48; P< 0.001). Changes in the physiological variables were similar (P> 0.05) with good consistency (ICC= 0.68–0.95) between 6MWT and 1-STST. Both lowest SpO2 and difference in SpO2 also showed good agreement (ICC= 0.86; 95% confidence interval [CI], 0.77–0.92 and ICC= 0.68; 95% CI, 0.47–0.81 respectively) and significant correlation (r = 0.76 and r= 0.52, respectively). 1-STST and 6MWT were consistent in identifying patients having oxygen desaturation ≥ 4% (κ= 0.56; 96% CI, 0.30–0.82). The results demonstrated that the performance of 1-STST was consistent with 6MWT in terms of exercise capacity and change in physiological parameters. 1-STST can be a valid alternative to 6MWT in the assessment of ILD patients, especially in peripheral health centers.

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