The present investigation evaluated the relations between anxiety sensitivity and motivational bases of cigarette smoking, as well as barriers to quitting smoking, above and beyond concurrent substance use, negative affectivity, and emotional dysregulation among a community sample of 189 daily cigarette smokers (46% women; M age = 24.97 years, SD = 9.78). Results indicated that anxiety sensitivity was significantly related to coping, addictive, and habitual smoking motives, as well as greater perceived barriers to quitting. These effects were evident above and beyond the variance accounted for by concurrent tobacco, alcohol, and marijuana use and discernable from shared variance with negative affectivity and emotional dysregulation. Emotional dysregulation was significantly related to stimulation, habitual, and sensorimotor smoking motives and greater perceived barriers to quitting, whereas negative affectivity was only significantly related to smoking for relaxation. These findings uniquely add to a growing literature suggesting anxiety sensitivity is an important and unique cognitive factor for better understanding clinically-relevant psychological processes related to cigarette smoking.There has been an increased effort to better understand linkages between tobacco use and anxiety disorders (Brown & Wolfe, 1994;Feldner, Babson, & Zvolensky, 2007;Kalman, Morissette, & George, 2005;Koenen et al., 2006;Morissette, Tull, Gulliver, Kamholz, & Zimering, 2007;Morrell & Cohen, 2006;Patton, Carlin, Coffey, Wolfe, Hibbert, & Bowes, 1998;Zvolensky, Bernstein, Marshall, & Feldner, 2006;Zvolensky, Feldner, Leen-Feldner, & McLeish, 2005). These scientific activities are theoretically and clinically important as there are bidirectional relations between tobacco use and anxiety and its disorders (Morissette et al., 2007;Morrell & Cohen, 2006;Zvolensky & Bernstein, 2005).An important cognitively-based individual difference factor relevant to psychologically-based smoking processes is anxiety sensitivity (AS). AS is the fear of anxiety and arousal-related sensations (McNally, 2002), and it has been conceptualized as a trait-like, cognitive predisposition for anxiety and stress-related psychopathology Taylor, 1999) that is malleable if targeted via cognitive-behavioral or pharmacological clinical Correspondence concerning this article should be addressed to Michael J. Zvolensky, Ph.D. Dr. Zvolensky can be contacted at The University of Vermont, Department of Psychology, 2 Colchester Avenue, John Dewey Hall, Burlington, VT 05405-0134, 802-656-8994 (phone), 802-656-8783 (facsimile); electronic mail may be sent to Michael.Zvolensky@uvm.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may...