Predictors of pregnancy outcome for infertile couples attending IVF and ICSI programmes

Zhang, Z.; Zhu, Leilei; Jiang, Hongru; Chen, H.; Chen, Y.; Dai, Yutian

doi:10.1111/and.12525

Cited by 22 publications

(10 citation statements)

References 45 publications

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“…As summarized in Table 1, several studies have attempted to identify clinical SDF cut-offs for the prediction of natural or ART-related pregnancy [126][127][128][129][130][131]. Although there remains no unanimous consensus on a specific cut-off value, a recent meta-analysis suggests that a cut-off of 20% can potentially differentiate between fertile and infertile men [108].…”

Section: What Test Should I Order?mentioning

confidence: 99%

Sperm DNA Fragmentation: A New Guideline for Clinicians

Agarwal

Majzoub

Baskaran

et al. 2020

World J Mens Health

169

144

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Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases of spermatogenesis, which imparts compaction and protects the genetic content. Testicular (defective maturation and abortive apoptosis) and post-testicular (oxidative stress) mechanisms are implicated in the etiology of sperm DNA fragmentation (SDF), which affects both natural and assisted reproduction. Several clinical and environmental factors are known to negatively impact sperm DNA integrity. An increasing number of reports emphasizes the direct relationship between sperm DNA damage and male infertility. Currently, several assays are available to assess sperm DNA damage, however, routine assessment of SDF in clinical practice is not recommended by professional organizations. This article provides an overview of SDF types, origin and comparative analysis of various SDF assays while primarily focusing on the clinical indications of SDF testing. Importantly, we report four clinical cases where SDF testing had played a significant role in improving fertility outcome. In light of these clinical case reports and recent scientific evidence, this review provides expert recommendations on SDF testing and examines the advantages and drawbacks of the clinical utility of SDF testing using Strength-Weaknesses-Opportunities-Threats (SWOT) analysis.

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Section: What Test Should I Order?mentioning

confidence: 99%

Sperm DNA Fragmentation: A New Guideline for Clinicians

Agarwal

Majzoub

Baskaran

et al. 2020

World J Mens Health

169

144

View full text Add to dashboard Cite

show abstract

“…Since the middle and late abortion rate were not significantly different among the groups, we suggested that the difference in results was mainly due to the increased early abortion rate of the CryoloopTM group. Many studies have confirmed the female age as an independent predictor for outcomes of IVF (Zhang et al 2016;Loendersloot et al 2010). Although the higher age in the CryoloopTM group (33.29 ± 4.71 years vs. 31.96 ± 4.27 years for CryotopTM, and 31.3 ± 4.28 years for CryoleafTM, p < 0.05) may contribute to a higher early abortion rate, it cannot completely explain the increase of more than 15%.…”

Section: Resultsmentioning

confidence: 99%

Effects of different open cryo-carriers on embryo survival and clinical outcome in frozen embryo transfer cycle patients

Chu

Zhou

et al. 2018

Systems Biology in Reproductive Medicine

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LN: liquid nitrogen; CPA: cryoprotectant; ART: assisted reproductive technology; IVF: in vitro fertilization; ICSI: intracytoplasmic sperm injection; BMI: body mass index; FSH: follicular stimulation hormone; COH: controlled ovarian hyperstimulation; FET: frozen embryo transfer; mm: millimeter; HCG: human chorionic gonadotropin; RCT: randomized clinical trial; NC: natural cycle; AC: artificial cycle; EM: equilibration medium; DMSO: dimethyl sulphoxide; EG: ethylene glycol; VM: vitrification medium; WM: warming medium.

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“…Infertile men appear to have more genomes impaired than fertile males [23,24]. Analysis of the heterogeneity of sperm DNA as an indicator of the outcome of an ART attempt (IVF or ICSI) has been extensively reported on in recent years [6,[25][26][27]. Indeed, several studies: such as the meta-analysis for Simon et al, 2017 [28] highlight the role of the male genome in the artificial reproductive stages, particularly during fertilization and early embryonic development.…”

Section: Discussionmentioning

confidence: 99%

Impact of Paternal Genome with a High DNA Fragmentation Index (>60%) on Early Embryonic Development

Hachemi¹

2021

Int. J. Gynecol. Obst. Res.

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: Objectives: The objective of this study is to propose thresholds of the sperm DNA fragmentation rate (IFA≤30% IFA31%-60% IFA>60%), in order to assess the clinical effects of the paternal genome on intra cytoplasmic sperm injection parameters, in particular the effect of the latter on early embryonic development. Materials and Methods: The procedure is a retrospective study, which involved 101 patients enrolled in an ICSI program with their partners. The index of spermatic DNA fragmentation rate was measured using the Sperm Chromatin Dispersion assay. Results: There is a negative correlation between high levels of the spermatic DNA fragmentation index and spermiological characteristics: Concentration P=0.002 and mobility P=0.0001. For ICSI results, there are different observations on the existence of a correlation between the spermatic DNA fragmentation index and fertility rate. On the other hand, the rate of sperm DNA fragmentation does not seem to influence early embryonic development, and even couples whose partners have a high fragmentation index manage to obtain the best quality embryos (P=0.002). We observe a decrease in the rate of implantation with an increase in the rate of alteration of the sperm genome, but this remains insignificant P > 0.05. Conclusion: ICSI remains the only alternative for men with a high rate of sperm DNA fragmentation. Moreover, the operator seems to influence the results more than is suggested. This does not exclude the paternal effect which may influence the quality of the concepltus later on. Keywords: DNA Fragmentation Index, ICSI, Fertilization Rate, Embryos Quality.

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Predictors of pregnancy outcome for infertile couples attending IVF and ICSI programmes

Cited by 22 publications

References 45 publications

Sperm DNA Fragmentation: A New Guideline for Clinicians

Sperm DNA Fragmentation: A New Guideline for Clinicians

Effects of different open cryo-carriers on embryo survival and clinical outcome in frozen embryo transfer cycle patients

Impact of Paternal Genome with a High DNA Fragmentation Index (>60%) on Early Embryonic Development

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