Predictors of Postacute Sequelae of COVID-19 Development and Rehabilitation: A Retrospective Study

Abdelwahab, Nermine; Ingraham, Nicholas E.; Nguyen, Nguyen; Siegel, Lianne; Silverman, Greg; Sahoo, Himanshu S.; Pakhomov, Serguei; Morse, Leslie R.; Billings, Joanne; Usher, Michael; Melnik, Tanya; Tignanelli, Christopher J.; Ikramuddin, Farha

doi:10.1016/j.apmr.2022.04.009

Cited by 6 publications

(10 citation statements)

References 24 publications

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“…Fourteen studies had a cross-sectional design [ 41 , 43 – 52 , 54 , 57 , 59 ], while the rest ( n = 5) followed a longitudinal design [ 42 , 53 , 55 , 56 , 58 ]. Twelve of the 14 cross-sectional studies conducted surveys, collecting their data at one time point only.…”

Section: Resultsmentioning

confidence: 99%

“…Two studies worked with already existing survey data, which were also collected at one time point [ 47 , 57 ]. Four of the five longitudinal studies analysed health records [ 42 , 53 , 55 ] and insurance data [ 56 ] over defined time periods. One study defined a subsample from an existing cohort study where the same individuals were surveyed three times: 1 month before, around the time of, and 12 weeks after infection [ 58 ].…”

Section: Resultsmentioning

confidence: 99%

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Social Inequalities in Long-Term Health Effects After COVID-19—A Scoping Review

Lammers,

Beese,

Hoebel

et al. 2024

Int J Public Health

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Objectives: We aimed to map and synthesize evidence about social inequalities in long-term health effects after COVID-19 (LTHE), often referred to as “long COVID” or “post-COVID-19 conditions.”Methods: We conducted a scoping review of peer-reviewed articles by searching the databases Embase and Scopus. According to predefined inclusion criteria, titles/abstracts and full texts were screened for eligibility. Additionally, reference lists of all included studies were hand-searched for eligible studies. This study followed the PRISMA guidelines for scoping reviews.Results: Nineteen articles were included. LTHE were analysed according to ethnicity, education, income, employment and deprivation indices. The studies varied significantly in their definitions of LTHE. Eighty-two analyses showed no statistically significant associations. At least 12 studies had a high risk of type II errors. Only studies associating deprivation indices and long COVID tended to show a higher prevalence of LTHE in deprived areas.Conclusion: Although some studies indicated social inequalities in LTHE, evidence was generally weak and inconclusive. Further studies with larger sample sizes specifically designed to detect social inequalities regarding LTHE are needed to inform future healthcare planning and public health policies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Social Inequalities in Long-Term Health Effects After COVID-19—A Scoping Review

Lammers,

Beese,

Hoebel

et al. 2024

Int J Public Health

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“…It has also been reported that one in five patients aged 18–34 with no chronic medical conditions after COVID-19 did not return to their normal state of health ( 29 ). While information on the duration of long COVID is limited, reported cases have extended from weeks to over a year ( 18 , 33 ). However, recent studies indicate a decline in the incidence of long COVID cases post-pandemic, and this reduction has been associated with the advancement of vaccination ( 34 , 35 ) Additionally, the Wuhan variant has been associated with diverse physical symptoms and emotional and behavioral changes, indicating a substantial impact on long-term health outcomes ( 36 ).…”

Section: Epidemiology Of Long Covidmentioning

confidence: 99%

Pathophysiological, immunological, and inflammatory features of long COVID

Bohmwald,

Diethelm-Varela,

Rodríguez-Guilarte

et al. 2024

Front. Immunol.

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The COVID-19 pandemic continues to cause severe global disruption, resulting in significant excess mortality, overwhelming healthcare systems, and imposing substantial social and economic burdens on nations. While most of the attention and therapeutic efforts have concentrated on the acute phase of the disease, a notable proportion of survivors experience persistent symptoms post-infection clearance. This diverse set of symptoms, loosely categorized as long COVID, presents a potential additional public health crisis. It is estimated that 1 in 5 COVID-19 survivors exhibit clinical manifestations consistent with long COVID. Despite this prevalence, the mechanisms and pathophysiology of long COVID remain poorly understood. Alarmingly, evidence suggests that a significant proportion of cases within this clinical condition develop debilitating or disabling symptoms. Hence, urgent priority should be given to further studies on this condition to equip global public health systems for its management. This review provides an overview of available information on this emerging clinical condition, focusing on the affected individuals’ epidemiology, pathophysiological mechanisms, and immunological and inflammatory profiles.

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“…Among the many ways in which COVID-19 has impacted humanity, the most profound one may actually prove beneficial-a period of prodigious scientific discovery aimed at advancing global health [1][2][3][4][5][6][7][8][9][10][11][12][13]. Adding to the disciplines influenced by pandemicrelated research, this hypothesis explores intriguing evidence of microbe-virus interplay, combining verified epidemiological and biochemical reports with new preliminary analyses to argue for the role of microbial proteases in rationalizing coronavirus epidemiology trends, to illuminate potential opportunities for novel therapeutic strategies.…”

Section: Introductionmentioning

confidence: 99%

“…Statistical support for many posited risk factors has declined through the pandemic, but some, such as a link between severe COVID-19 and prior medical history of cardiovascular and metabolic disorders (primarily diabetes, hypertension, and obesity) have gained strength according to extensive sustained analysis [5]. Autoimmune risk factors have also been determined to correlate with COVID-19 severity [6,7] and predispose patients to post-acute sequelae [8,9]. Other epidemiologically significant factors include chronic exposure to air pollution [10,11], as well as one metric that assimilates numerous subfactors-socioeconomic status [12,13].…”

Section: Introductionmentioning

confidence: 99%

Bacterial Proteases as Potentially Exploitable Modulators of SARS-CoV-2 Infection: Logic from the Literature, Informatics, and Inspiration from the Dog

Lushington,

Linde,

Melgarejo

2023

BioTech

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(1) Background: The COVID-19 pandemic left many intriguing mysteries. Retrospective vulnerability trends tie as strongly to odd demographics as to exposure profiles, genetics, health, or prior medical history. This article documents the importance of nasal microbiome profiles in distinguishing infection rate trends among differentially affected subgroups. (2) Hypothesis: From a detailed literature survey, microbiome profiling experiments, bioinformatics, and molecular simulations, we propose that specific commensal bacterial species in the Pseudomonadales genus confer protection against SARS-CoV-2 infections by expressing proteases that may interfere with the proteolytic priming of the Spike protein. (3) Evidence: Various reports have found elevated Moraxella fractions in the nasal microbiomes of subpopulations with higher resistance to COVID-19 (e.g., adolescents, COVID-19-resistant children, people with strong dietary diversity, and omnivorous canines) and less abundant ones in vulnerable subsets (the elderly, people with narrower diets, carnivorous cats and foxes), along with bioinformatic evidence that Moraxella bacteria express proteases with notable homology to human TMPRSS2. Simulations suggest that these proteases may proteolyze the SARS-CoV-2 spike protein in a manner that interferes with TMPRSS2 priming.

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Predictors of Postacute Sequelae of COVID-19 Development and Rehabilitation: A Retrospective Study

Cited by 6 publications

References 24 publications

Social Inequalities in Long-Term Health Effects After COVID-19—A Scoping Review

Social Inequalities in Long-Term Health Effects After COVID-19—A Scoping Review

Pathophysiological, immunological, and inflammatory features of long COVID

Bacterial Proteases as Potentially Exploitable Modulators of SARS-CoV-2 Infection: Logic from the Literature, Informatics, and Inspiration from the Dog

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