Predictors of Post-Stroke Depression: A Retrospective Cohort Study

Chaudhary, Durgesh; Friedenberg, Isabel; Sharma, Vishakha; Sharma, Pragyan; Abedi, Vida; Zand, Ramin; Li, Jiang

doi:10.3390/brainsci12080993

Cited by 7 publications

(5 citation statements)

References 57 publications

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“…Identifying factors associated with PSD is very important due to the underdiagnosis and undertreatment of PSD. At present, various studies indicated that chronic stress (including financial and health-related stress, irrespective of age), [ 48 ] IL-33 concentration of ≤71.85 ng/L [ 49 ] significantly increased the risk for PSD. And Shi YZ et al pointed out that female gender, smoking, mild global cognitive impairment, and stroke recurrence predict early-onset or late-onset PSD after minor ischemic stroke.…”

Section: Discussionmentioning

confidence: 99%

Scientometric analysis of post-stroke depression research based on CiteSpace

et al. 2023

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Post-stroke depression (PSD) has served as a severe and common complication leading to a higher level of mortality. Though various studies have been focused on PSD, limited research endeavor has been dedicated to bibliometric analysis in the past. In view of this, the current analysis serves to elucidate the latest status of global research and pinpoint the emerging area of interest for PSD, in order to support further investigation of the field. Publications related to PSD were retrieved from the Web of Science Core Collection database on September 24, 2022, and included in the bibliometric analysis. VOSviewer and CiteSpace software were used to visually analyze publication outputs, scientific cooperation, highly-cited references, and keywords to identify the current status and future trends in PSD research. A total of 533 publications were retrieved. The annual number of publications showed an increasing trend from 1999 to 2022. In terms of country and academic institution, the USA and Duke University have topped the list of PSD research respectively. Meanwhile, Robinson RG and Alexopoulos GS have been the most representative investigators of the field. In the past, researchers focused on the risk factors of PSD, late-life depression, and Alzheimer disease. In recent years, further research effort has been placed on meta-analysis, ischemic stroke, predictor, inflammation, mechanism, and mortality. In conclusion, in the past 20 years, PSD research has been progressing and gaining more attention. The bibliometric analysis successfully unveiled the field’s major contributing countries, institutions, and investigators. Furthermore, current hot spots and future trends in the field of PSD were identified, which included meta-analysis, ischemic stroke, predictor, inflammation, mechanism, and mortality.

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Section: Discussionmentioning

confidence: 99%

Scientometric analysis of post-stroke depression research based on CiteSpace

et al. 2023

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“… 16 , 17 While the one-third prevalence rate for PSD is well-supported across studies, some studies have reported lower rates ranging from 15.8% to 21%, depending on setting and time since stroke. 18 , 19 Higher rates have also been reported, and the cumulative incidence of PSD may be as high as 55%. 20 The varying rates of depression after stroke are due to combined factors, mostly related to methodology.…”

Section: Post Stroke Depressionmentioning

confidence: 99%

“…Research suggests that marital status, years of education, history of prior stroke and/or history of myocardial infarction, recent life stressors, poverty, and lack of social supports are associated with a higher incidence of depression following a stroke. 18 , 21 , 31 …”

Section: Risk Factorsmentioning

confidence: 99%

Evaluation & Treatment of Psychological Effects of Stroke

Devereux,

Berns

2023

Delaware Journal of Public Health

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Strokes are a common medical condition in the United States, including in Delaware. An under-recognized effect of stroke is the impact on mood that often occurs. Many individuals develop depression, anxiety, PTSD, and other psychological sequelae. These disorders can significantly affect their lives and their relationships. The emotional effects of stroke pose a public health problem for our residents, leading to devastating decreases in the quality of life for the patient and the family. These challenges negatively impact the community due to the associated healthcare and economic burdens. The population of the State of Delaware is growing, and the proportion of senior residents, who are also at greater risk for strokes, is also increasing. Strokes will remain an ongoing important clinical concern for our healthcare providers. Emotional changes after a stroke will occur in many Delaware residents who suffer a stroke. The emotional sequelae of stroke are under-treated. It is critical for healthcare professionals to be trained to recognize, assess, and treat the psychological disorders that can result from having a stroke. This article provides an overview of the major psychological effects of stroke, recommended assessment tools, promising treatment trends, and directions for further research. Improving our ability to detect and treat these difficult emotional challenges can facilitate effective treatment and prevention strategies and increase quality of life for stroke survivors, their loved ones, and their communities.

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“…Previous studies identified several risk factors for PSD. For example, PSD occurs at a greater rate after left-hemispheric stroke [ 7 ], strokes in the frontal lobe or basal ganglia [ 8 ], more anterior location of stroke [ 9 ], more severe stroke [ 3 ], level of physical disability [ 10 ], level of dependence on others [ 11 ], history of previous stroke [ 11 ], chronic accumulation of small macrovascular and microvascular lesions [ 12 ], female gender [ 13 ], treatment for depression prior to stroke [ 10 ], diabetes mellitus [ 14 ], history of myocardial infarction [ 15 ], stressful life events in the months before stroke [ 13 ], living alone at time of stroke [ 16 ], Medicaid patients (versus private insurance patients) [ 15 ], and lower educational attainment [ 16 ]. Comorbidities such as pseudobulbar affect [ 13 ], anxiety [ 3 ], and greater cognitive impairment are more common in patients with PSD [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Biological, Psychiatric, Psychosocial, and Cognitive Factors of Poststroke Depression

Dulay

Criswell

Hodics

2023

IJERPH

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Background: Depression is the most common psychiatric condition that occurs after cerebrovascular accident, especially within the first year after stroke. Poststroke depression (PSD) may occur due to environmental factors such as functional limitations in daily activities, lower quality of life, or biological factors such as damage to areas in the brain involved in emotion regulation. Although many factors are hypothesized to increase the risk of PSD, the relative contribution of these factors is not well understood. Purpose: We evaluated which cross-sectional variables were associated with increased odds of PSD in our adult outpatient stroke neuropsychology clinic population. Methods: The sample included 325 patients (49.2% female; mean age of 59-years old) evaluated at an average of 8.1 months after an ischemic or hemorrhagic stroke. Variables included in logistic regression were stroke characteristics, demographics, psychosocial factors, comorbid medical problems, comorbid psychiatric conditions, and cognitive status. The Mini International Neuropsychiatric Inventory was used to determine DSM-defined PSD and anxiety disorders. A standard neuropsychological test battery was administered. Results: PSD occurred in 30.8% of the sample. Logistic regression indicated that increased odds of PSD were associated with a comorbid anxiety disorder (5.9 times more likely to suffer from PSD, p < 0.001). Further, increased odds of PSD were associated with a history of depression treatment before stroke (3.0 times more likely to suffer from PSD), fatigue (2.8 times more likely), memory impairment (2.4 times more likely), and younger age at stroke (all p values < 0.006). Discussion: Results suggest that PSD is likely multifactorial and extends the literature by demonstrating that a comorbid anxiety disorder correlated strongest with PSD. Poststroke screening and treatment plans should address not only depression but comorbid anxiety.

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Predictors of Post-Stroke Depression: A Retrospective Cohort Study

Cited by 7 publications

References 57 publications

Scientometric analysis of post-stroke depression research based on CiteSpace

Scientometric analysis of post-stroke depression research based on CiteSpace

Evaluation & Treatment of Psychological Effects of Stroke

Biological, Psychiatric, Psychosocial, and Cognitive Factors of Poststroke Depression

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