Predictors of positive food challenge outcome in non–IgE-mediated reactions to food in children with atopic dermatitis

Niggemann, B.; Reibel, Susanne; Roehr, Charles Christoph; Felger, Dorothée; Ziegert, Mandy; Sommerfeld, Christine; Wahn, Ulrich

doi:10.1067/mai.2001.120192

Cited by 129 publications

(42 citation statements)

References 30 publications

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“…However, the possible role of foods causing worsening of established eczema by a non-IgE-mediated mechanism remains controversial. A number of studies have used double-blind placebo-controlled food challenges to demonstrate that food allergens, and in particular, CMPs are able to induce delayed eczematous reactions in children even in the absence of an immediate, histamine-mediated, component 29 69 70. However, attempts to show that dietary exclusions can objectively influence the course of atopic eczema have remained unconvincing.…”

Section: Immune-mediated Reactions To Cow's Milkmentioning

confidence: 99%

Identifying and managing cow's milk protein allergy

Toit

Shah

Heine

et al. 2010

Archives of Disease in Childhood - Education and Practice

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Cow's milk protein (CMP) is usually one of the first complementary foods to be introduced into the infant's diet and is commonly consumed throughout childhood as part of a balanced diet. CMP is capable of inducing a multitude of adverse reactions in children, which may involve organs like the skin, gastrointestinal (GI) tract or respiratory system. The diagnosis of CMP-induced adverse reactions requires an understanding of their classification and immunological basis as well as the strengths and limitations of diagnostic modalities. In addition to the well-recognised, immediate-onset IgE-mediated allergies, there is increasing evidence to support the role of CMP-induced allergy in a spectrum of delayed-onset disorders ranging from GI symptoms to chronic eczema. The mainstay of treatment is avoidance of CMP; this requires dietetic input to ensure that this does not lead to any nutritional compromise. This review is intended to highlight the broad spectrum of manifestations of CMP allergy and to offer an approach to the diagnosis and treatment thereof.

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Section: Immune-mediated Reactions To Cow's Milkmentioning

confidence: 99%

Identifying and managing cow's milk protein allergy

Toit

Shah

Heine

et al. 2010

Archives of Disease in Childhood - Education and Practice

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“…DBPCFC remains the golden standard in diagnosis of food allergy (Niggemann, Reibel, Roehr, & Wahn, 2001).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of food allergy to wheat, cow milk, egg, soy and peanuts in patients suffering from atopic dermatitis

Čelakovská

Ettlerová

Vaněčková

et al. 2013

Food and Agricultural Immunology

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Few large studies concerning the importance of food allergy in adolescents and adult patients with atopic dermatitis exist. The evaluation of food allergy to egg white and yolk, peanuts, soy, cow milk and wheat in patients suffering from atopic dermatitis. Two hundred forty patients (70 men, 170 women) were examined. Complete dermatological and allergological examination was performed in all patients, including specific IgE, skin prick test and atopy patch test. The challenge test was performed according to the results of examinations with suspected foods. The food allergy to peanuts was confirmed in 20% of patients, to egg in 6%, to soy in 3.3%, to wheat in 2.5% and to milk in 0.8% -altogether in 65 patients (27.5%). The positive results in examinations without clinical symptoms of food allergy were recorded in another 78 patients (32.5%). The diagnostic work-up should comprise not only the laboratory methods, but also the diagnostic hypoallergenic diet and the challenge test.

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“…Nine of them had negative CAP/RAST results, despite positive open challenge. Niggemann et al (2001) provided evidence that nonIgE mediated mechanisms are responsible for over 20% of positive challenge reactions to wheat in children with atopic dermatitis. More recently, the Finnish group already mentioned (Palosuo et al, 2001a) showed immediate (48%) and delayed (20%) hypersensitivity symptoms in 27 out of 40 children submitted to open or double blind oral wheat challenge, recruited on the basis of a history suggestive of wheat allergy.…”

Section: Wheat and Other Gluten-containing Cerealsmentioning

confidence: 99%

“…This approach, although theoretically interesting and appealing, has yielded conflicting results in clinical studies of different populations (Osterballe and Bindslev-Jensen, 2003;Sampson, 2001;Boyano Martínez et al, 2001;Morisset et al, 2003a;Niggemann et al, 2001). Since the specific IgE levels and skin test are only loosely related to the likelihood and severity of an allergic reaction and currently only applicable to a small number of allergens (for example peanut, egg and milk), knowing the specific immunological sensitisation level will not be helpful for the consumer or allow the industry to safely target products to consumers with different degrees of sensitisation.…”

Section: Prediction Of Individual's Sensitivity and Allergen Thresholdmentioning

confidence: 99%

“…The finding of a positive oral challenge to wheat in patients with no evidence of sensitisation is another peculiarity of wheat allergy, as pointed out by Simonato et al (2001a) and Niggemann et al (2001). Simonato et al (2001a) selected twenty patients affected by irritable bowel syndrome in whom hypersensitivity to wheat was suspected on the basis of history and results of elimination diet and open oral challenge.…”

Section: Wheat and Other Gluten-containing Cerealsmentioning

confidence: 99%

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Opinion of the Scientific Panel on Dietetic products, nutrition and allergies [NDA] on a request from the Commission relating to the evaluation of allergenic foods for labelling purposes

2004

EFS2

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Predictors of positive food challenge outcome in non–IgE-mediated reactions to food in children with atopic dermatitis

Cited by 129 publications

References 30 publications

Identifying and managing cow's milk protein allergy

Identifying and managing cow's milk protein allergy

Evaluation of food allergy to wheat, cow milk, egg, soy and peanuts in patients suffering from atopic dermatitis

Opinion of the Scientific Panel on Dietetic products, nutrition and allergies [NDA] on a request from the Commission relating to the evaluation of allergenic foods for labelling purposes

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