Predictors of PCP, OH-PCBs, PCBs and chlorinated pesticides in a general female Norwegian population

Rylander, Charlotta; Lund, Eiliv; Frøyland, Livar; Sandanger, Torkjel M.

doi:10.1016/j.envint.2012.02.008

Cited by 51 publications

(53 citation statements)

References 39 publications

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“…In agreement with most other studies (Caspersen et al 2016;Fernandez-Rodriguez et al 2015;Long et al 2015;Medehouenou et al 2011;Porta et al 2012;Rylander et al 2012;Sandau et al 2000;Wolff et al 2005), we found that the PCB and OCP concentrations were higher in older women (Table 4). This association is presumed to be a reflection of the persistency and long human serum half-life of the lipophilic POPs.…”

Section: Associations Between the Lipophilic Pop Concentrations And Tsupporting

confidence: 95%

“…Several studies have reported that the lipophilic POP concentrations are associated with age (Fernandez-Rodriguez et al 2015;Long et al 2015;Medehouenou et al 2011;Porta et al 2012;Rylander et al 2012;Sandau et al 2000;Wolff et al 2005), BMI (Fernandez-Rodriguez et al 2015;Halldorsson et al 2008b;Medehouenou et al 2011;Porta et al 2012;Wolff et al 2005), smoking status (Deutch et al 2007(Deutch et al , 2003Fernandez-Rodriguez et al 2015;Wolff et al 2005), and gestational age at blood draw (Adetona et al 2013;Longnecker et al 1999). Hence, in the present study, the temporal trends were analyzed for the lipidcorrected crude data and upon adjustment for these potential confounders.…”

Section: Statisticsmentioning

confidence: 98%

“…The temporal changes of lipophilic POP concentrations have not been studied much in Europe in recent years, and to our knowledge, no time trend studies have been conducted in Denmark. The lipophilic POP concentrations in human serum may be dependent on factors such as age, body mass index (BMI), parity, and gender (Caspersen et al 2016;Fernandez-Rodriguez et al 2015;Long et al 2015;Medehouenou et al 2011;Porta et al 2012;Rylander et al 2012;Sandau et al 2000;Wolff et al 2005). Hence, it is important to control for these covariates when conducting a time trend study by e.g., selecting a homogenous population such as nulliparous pregnant women.…”

Section: Responsible Editor: Hongwen Sunmentioning

confidence: 98%

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Temporal trends of lipophilic persistent organic pollutants in serum from Danish nulliparous pregnant women 2011–2013

Bjerregaard-Olesen

Long

Ghisari

et al. 2017

Environ Sci Pollut Res

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The use of the lipophilic persistent organic pollutants (POPs) including polychlorinated biphenyls (PCBs) and several organochlorine pesticides (OCPs) has been prohibited for more than 30 years. In this study, we present the temporal trends of the lipophilic POP serum concentrations in Danish nulliparous pregnant women between 2011 and 2013. We randomly selected 197 pregnant women (gestational age 11-13) from the Aarhus Birth Cohort. The concentrations of the lipophilic POPs in the serum samples were analyzed using gas chromatography. The concentrations were corrected for total serum lipids. The statistical analysis was performed by regression analysis with adjustment for age, BMI, gestational age at blood draw, and smoking status. The serum concentrations of PCB 118, 138, 153, 156, 170, 180, 187, and hexachlorobenzen, trans-nonachlor, β-hexachlorocyclohexane (β-HCH), and p,p'-dichlorodiphenyldichloroethylene were lower in 2013 than in 2011. However, the oxychlordane concentration was lowest in 2011. The serum levels of most lipophilic POPs followed downward trends during the study period, which was expected, as these compounds has been banned for many years. The upward trend of oxychlordane was unexpected and presumably a chance finding.

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Section: Associations Between the Lipophilic Pop Concentrations And Tsupporting

confidence: 95%

Section: Statisticsmentioning

confidence: 98%

Section: Responsible Editor: Hongwen Sunmentioning

confidence: 98%

See 1 more Smart Citation

Temporal trends of lipophilic persistent organic pollutants in serum from Danish nulliparous pregnant women 2011–2013

Bjerregaard-Olesen

Long

Ghisari

et al. 2017

Environ Sci Pollut Res

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“…The mechanism of PCB to hydroxylated polychlorinated biphenyls (OH-PCBs) metabolism generally involves the insertion of a OH-group on a biphenyl via arene oxide intermediate formation, possibly followed by 1,2 shift (NIH shift) [1,2] or via direct insertion of the hydroxyl group [3]. Despite the fact that most phenolic compounds are readily conjugated and excreted, several OH-PCBs have been found to be retained in human and wildlife blood [4][5][6][7][8] and due to their structural similarity to natural hormones have been shown endocrine-related toxicity, being capable of interacting and disrupting the thyroid hormone status in humans [9][10][11]. Approximately 40 different congeners have been identified in human plasma [12], [13], which are predominantly penta-through heptachlorinated OH-PCBs (4-OH-CB187, 4-OH-CB107, 4-OH-CB146, 3-OH-CB153 and 3-OH-CB138 [12,14,15].…”

Section: Introductionmentioning

confidence: 99%

Fast determination of hydroxylated polychlorinated biphenyls in human plasma by online solid phase extraction coupled to liquid chromatography-tandem mass spectrometry

Quinete

Kraus

Belov

et al. 2015

Analytica Chimica Acta

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“…As a result of the ubiquitous presence of both PCP and PFOS (PFOA) in the environment, it is possible for human to expose to them simultaneously. In the NOWAC (national representative Norwegian Women And Cancer) study, it was reported that the median concentrations of PFOS and PCP in plasma were 20 and 0.77 lg L À1 in a general female Norwegian population, respectively (Rylander et al, 2010(Rylander et al, , 2012.…”

Section: Introductionmentioning

confidence: 99%

Enhanced cytotoxicity of pentachlorophenol by perfluorooctane sulfonate or perfluorooctanoic acid in HepG2 cells

et al. 2013

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h i g h l i g h t sPFOS and PFOA could enhance the cytotoxity of PCP to HepG2 cells. PFOS displayed stronger synergistic cytotoxicity with PCP than PFOA. Cytotoxic enhancement might be via strengthening the phosphorylation uncoupling of PCP. PFOS and PFOA might cause membrane disruption and improve the uptake of PCP. a r t i c l e i n f o t r a c tChlorinated phenols and perfluoroalkyl acids (PFAAs) are two kinds of pollutants which are widely present in the environment. Considering liver is the primary toxic target organ for these two groups of chemicals, it is interesting to evaluate the possible joint effects of them on liver. In this work, the combined toxicity of pentachlorophenol (PCP) and perfluorooctane sulfonate (PFOS) or perfluorooctanoic acid (PFOA) were investigated using HepG2 cells. The results indicated that PFOS and PFOA could strengthen PCP's hepatotoxicity. Further studies showed that rather than intensify the oxidative stress or promote the biotransformation of PCP, PFOS (or PFOA) might lead to strengthening of the oxidative phosphorylation uncoupling of PCP. By measuring the intracellular PCP concentration and the cell membrane properties, it was suggested that PFOS and PFOA could disrupt the plasma membrane and increase the membrane permeability. Thus, more cellular accessibility of PCP was induced when they were co-exposed to PCP and PFOS (or PFOA), leading to increased cytotoxicity. Further research is warranted to better understand the combined toxicity of PFAAs and other environmental pollutants.

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Predictors of PCP, OH-PCBs, PCBs and chlorinated pesticides in a general female Norwegian population

Cited by 51 publications

References 39 publications

Temporal trends of lipophilic persistent organic pollutants in serum from Danish nulliparous pregnant women 2011–2013

Temporal trends of lipophilic persistent organic pollutants in serum from Danish nulliparous pregnant women 2011–2013

Fast determination of hydroxylated polychlorinated biphenyls in human plasma by online solid phase extraction coupled to liquid chromatography-tandem mass spectrometry

Enhanced cytotoxicity of pentachlorophenol by perfluorooctane sulfonate or perfluorooctanoic acid in HepG2 cells

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