Predictors of pain during oocyte retrieval

Frederiksen, Yoon; Mehlsen, Mimi; Matthiesen, Signe Maria Schneevoigt; Zachariae, Robert; Ingerslev, Hans Jakob

doi:10.1080/0167482x.2016.1235558

Cited by 13 publications

(7 citation statements)

References 31 publications

(26 reference statements)

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“…Aside from the administered analgesia, pain scores are also affected by psychosocial factors. A study by Frederiksen et al showed that women who had a high level of anxiety, a low level of perceived control, or negative gynaecological experiences in the past, reported higher pain scores [4]. These findings support the administration of an anxiolytic in order to reduce pain during oocyte retrieval.…”

Section: Discussionmentioning

confidence: 90%

Different methods of pain relief for IVF and ICSI oocyte retrieval – A Dutch survey

Roest

Buisman

Steeg

et al. 2019

European Journal of Obstetrics & Gynecology and Reproductiv

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Objective Which analgesia methods are used during oocyte retrieval in the Netherlands? StudyDesign In April 2017, an online survey containing questions on the analgesia protocol used for IVF/ICSI oocyte retrieval was sent to all clinics in the Netherlands that perform oocyte retrievals. Results The response rate was 97%. We uncovered the large variety of medication protocols used for pain relief during oocyte retrieval in the Netherlands. Based on the main component of the given analgesia, we distinguished the three most frequently used analgesia protocols: intravenously (i.v.) administered opioids, intramuscularly (i.m) administered opioids, and non-sedative oral analgesics. Aside from analgesia, 61% provided anxiolysis with a benzodiazepine. Nearly half of the clinics registered pain scores. The vital functions were monitored at all clinics administering opioids i.v., but at none of the clinics administering opioids i.m. Conclusions A wide variety of analgesia protocols are used. The three most frequently used are i.v. administered opioids, i.m. administered opioids, and non-sedative oral analgesics. The variety of analgesia protocols is not desirable in the context of good clinical practice, and considering the risks of combining opioids and benzodiazepines. Monitoring of vital functions was only performed after administration of i.v. medication. A comparison of the pain scores could be a first step in finding the optimal method of analgesia, thereby forming the basis of guidelines for analgesia during oocyte retrieval.

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Section: Discussionmentioning

confidence: 90%

Different methods of pain relief for IVF and ICSI oocyte retrieval – A Dutch survey

Roest

Buisman

Steeg

et al. 2019

European Journal of Obstetrics & Gynecology and Reproductiv

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show abstract

“…These unpleasant experiences could results in excessive worry about IVF treatment. 21 A research of Yoon Frederiksenet al 22 has shown that about 7% of women feel distressed during oocyte retrieval. Combined with the ndings in the present study, anesthetic measures should and could be taken to relieve the pain in women receiving oocyte retrieval.…”

Section: Discussionmentioning

confidence: 99%

Effect of intravenous anesthetic drugs on fertilization rate in oocyte retrieval

Liu,

Gao,

et al. 2023

Preprint

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Background: The purpose of this study was to investigate the effects of intravenous anesthetic drugs on fertilization rate in subjects receiving oocyte retrieval by assisted reproduction technology (ART). Methods: Aretrospective cohort study was designed. The clinical information of subjects who received oocyte retrieval procedure was collected. The subjects were divided into two groups based on the type of anesthesia used: the no-anesthesia group and the intravenous anesthesia group. Propensity score matching (PSM) was performed and multiple linear regression analyses were conducted. Fertilization rate was compared between the two groups before and after PSM. Results: A total of 765 subjects were divided into two groups: the no-anesthesia group (n=482) and the intravenous anesthesia group (n=283). According to propensity scores, 258 pairs of subjects were well matched, and the baseline data between the two groups were not significantly different (P>0.05). Fertilization rate was 77% in the intravenous anesthesia group, and 76% in the no-anesthesia group, without significant between-group difference (P=0.685). Before matching, Poisson regression analysis showed no effect of intravenous anesthetic drugs on fertilization rate (RR=0.859, 95%CI: 0.59 to 1.25, P＞0.05). After matching, no difference was found either (RR=0.935, 95%CI: 0.67 to 1.29, P＞0.05). Conclusion: Intravenous anesthetic drugs may exert no effects on fertilization rate in subjects receiving ART.

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“…Second, patient's anxiety before OR was not assessed in our study. Indeed, higher levels of anxiety during oocyte retrieval seem positively associated with pain intensity and anxiety [14][15][16].…”

Section: Discussionmentioning

confidence: 99%

IVF oocyte retrieval: prospective evaluation of the type of anesthesia on live birth rate, pain, and patient satisfaction

Rolland

Perrin

Villes

et al. 2017

J Assist Reprod Genet

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Purpose Does the type of anesthesia (paracervical block (PCB) or general anesthesia (GA)) impact live birth rate, pain, and patient satisfaction? Methods A non-randomized prospective cohort study was conducted in women treated for IVF. Two groups of patients were prospectively included: the PCB group (n = 234) and the GA group (n = 247). The type of anesthesia was determined by the patients. The primary endpoint was cumulative live birth rate by OR. Secondary endpoints were self-assessment of the patients' peri-operative abdominal and vaginal pain vs the doctors' evaluations during PCB, post-operative abdominal and vaginal pain level, and patient satisfaction in both groups. Pain levels were assessed with a numerical rating scale (NRS). Results The live birth rate was similar in both groups (19.8% in the GA group vs 20.9% in the PCB group, P = 0.764). During oocyte retrieval in the PCB group, the physicians significantly underestimated the vaginal pain experienced by the patients (3.04 ± 0.173 for patients vs 2.59 ± 0.113 for surgeons, P = 0.014). Post-operative vaginal and abdominal pain were significantly greater in the PCB group compared to the GA group (2.26 ± 0.159 vs 1.66 ± 0.123, respectively, P = 0.005, and 3.80 ± 0.165 vs 3.00 ± 0.148, respectively, P < 0.001). Patients were more significantly satisfied with GA than with PBC (P < 0.001). Conclusion Because the LBR was similar in both groups and patient satisfaction was high, the choice of anesthesia should be decided by the patients.

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Predictors of pain during oocyte retrieval

Abstract: The findings of the present study may help to identify those women who are at increased risk of experiencing unacceptable pain levels during oocyte retrieval procedures and the medical staff is advised to take psychological factors into account.

Cited by 13 publications

References 31 publications

Different methods of pain relief for IVF and ICSI oocyte retrieval – A Dutch survey

Different methods of pain relief for IVF and ICSI oocyte retrieval – A Dutch survey

Effect of intravenous anesthetic drugs on fertilization rate in oocyte retrieval

IVF oocyte retrieval: prospective evaluation of the type of anesthesia on live birth rate, pain, and patient satisfaction

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