Predictors of outcome in thymectomy for myasthenia gravis

Budde, Jason M.; Morris, Cullen D.; Gal, Anthony A.; Mansour, Kamal A.; Miller, Joseph I.

doi:10.1016/s0003-4975(01)02678-9

Cited by 116 publications

(71 citation statements)

References 21 publications

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“…In contrast to previous studies, males were the dominant group in the present study. The atypical gender preponderance may have affected the clinical outcomes in this study, as a previous study found that female patients responded better than males (5). In contrast, another study found that gender did not affect clinical outcomes (8).…”

Section: Resultsmentioning

confidence: 71%

“…(4) first performed a thymectomy, with good outcomes, this procedure has been considered an effective treatment compliment to medical therapies. Previous studies reported improvement rates of 54-94% and remission rates of 13-46% following a thymectomy, making it the treatment of choice for MG (5,6). Similarly, our study showed good clinical outcomes, with an overall remission/ improvement rate of 87.5 and a clinical unchanged/worsened rate of 12.5% (Figure 3).…”

Section: Resultsmentioning

confidence: 99%

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Thymectomy for Myasthenia Gravis: A 10-year Review of Cases at the Hospital Universiti Sains Malaysia

Muhammed

Chen

Hitam

et al. 2016

MJMS

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Background: A thymectomy is considered effective for patients with myasthenia gravis (MG).Although a few studies have described the role of a thymectomy in the treatment of MG in Asians countries, there are no published data on the application of this surgical approach for MG in Malaysia. We aimed to describe the clinical outcomes of MG patients who underwent a thymectomy and the factors affecting these outcomes.Methods: This was a retrospective study involving 16 patients with MG who underwent a thymectomy at the Hospital Universiti Sains Malaysia (HUSM) from January 2002 until December 2012, with a follow-up period ranging from 3-120 months.Results: The study consisted of 16 patients aged 22-78 years, 10 of whom were males. The overall remission/improvement rate was 87.5%, and the rate of clinical outcomes classified as unchanged/ worsened was 12.5%. Thymomamatous or non-thymomamatous MG, histology features, Osserman stage and the duration of follow-up were not significant prognostic factors. Post-operative mortality was 6.2% (1 of 16 patients died of septic shock).Conclusion: A thymectomy seems to be an effective treatment for MG, with low surgical morbidity. Patients with a lower Osserman stage and those with/without thymomas had favourable outcomes.

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Section: Resultsmentioning

confidence: 71%

Section: Resultsmentioning

confidence: 99%

Thymectomy for Myasthenia Gravis: A 10-year Review of Cases at the Hospital Universiti Sains Malaysia

Muhammed

Chen

Hitam

et al. 2016

MJMS

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“…Treatment with thymectomy may not significantly improve the course of thymoma associated myasthenia gravis 18 . Standerd primary treatment for these types of tumors is surgical with enbloc resection for invasive tumors, if possible.This report suggest our line of management 19,20 .…”

Section: Discussionmentioning

confidence: 95%

Thymoma Presenting as a Giant Intrathoracic Mass

Hasan¹,

Khan²,

Nahian³

et al. 2016

J. Bangladesh Coll. Phys.

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Summary:Thymoma is an epithelial neoplasm of the thymus, which commonly lies in the anterior mediastinum. Thymomas comprise about 1% of all mediastinal tumours. The current treatment of invasive thymoma is often multidisciplinary. This report presents a case of giant thymoma arising in the anterior mediastinum. Introduction:Thymomas are epithelial neoplasm of the thymus.The overall incidence of thymoma is rare, which approximately 0.15 cases per 100,000 of the population per year 1 . Thymoma account for about 20 percent of mediastinal neoplasm. Localization of thymoma resembles that of thymus itself with 75% of thymoma originating in anterior mediastinum,15% originating in both anterior and superior mediastinum, 6% originating in the superior mediastinum.Other 4% occur ectopically 2 . In general, thymomas are indolent tumors with local recurrence rather than metastasis. Thymic carcinomas, however, are typically invasive, with high risk of relapse and death 3,4 . Most thymomas patients are between 40 to 60 years of age, and there is slight male predominance. Invasive thymomas and thymic carcinomas are relatively rare tumors, which together represent about 0.2-1.5% of all malignancies 5 . The major

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“…16 In total, 80% of MG patients show symptomatic improvement after undergoing a thymectomy. 17,18 One year after a thymectomy, the MG remission rate is <20%, although this rises to 50% after 7-10 years. 19 The Association of British Neurologists have previously published detailed clinician guidelines to inform the management and treatment of MG patients.…”

Section: Treatment Of Myasthaenia Gravismentioning

confidence: 99%

Myasthaenia Gravis: Clinical management issues before, during and after pregnancy

Hassan¹,

Yasawy²

2017

SQUMJ

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Myasthaenia gravis (MG) is an autoimmune neuromuscular disorder which is twice as common among women, often presenting in the second and third decades of life. Typically, the first trimester of pregnancy and first month postpartum are considered high-risk periods for MG exacerbations. During pregnancy, treatment for MG is usually individualised, thus improving its management. Plasma exchange and immunoglobulin therapies can be safely used to treat severe manifestations of the disease or myasthaenic crises. However, thymectomies are not recommended because of the delayed beneficial effects and possible risks associated with the surgery. Assisted vaginal delivery-either vacuum-assisted or with forceps-may be required during labour, although a Caesarean section under epidural anaesthesia should be reserved only for standard obstetric indications. Myasthaenic women should not be discouraged from attempting to conceive, provided that they seek comprehensive counselling and ensure that the disease is under good control before the start of the pregnancy.

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Predictors of outcome in thymectomy for myasthenia gravis

Cited by 116 publications

References 21 publications

Thymectomy for Myasthenia Gravis: A 10-year Review of Cases at the Hospital Universiti Sains Malaysia

Thymectomy for Myasthenia Gravis: A 10-year Review of Cases at the Hospital Universiti Sains Malaysia

Thymoma Presenting as a Giant Intrathoracic Mass

Myasthaenia Gravis: Clinical management issues before, during and after pregnancy

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