Predictors of outcome in patients with metastatic cutaneous head and neck squamous cell carcinoma involving cervical lymph nodes: Improved survival with the addition of adjuvant radiotherapy

Abstract

In patients with metastatic cutaneous HNSCC involving cervical nodes, survival was significantly improved with the addition of radiotherapy.

Outcomes of nodal metastatic cutaneous squamous cell carcinoma of the head and neck treated in a regional center

“…The majority of patients treated at our center received adjuvant radiotherapy, in accordance with the consensus in the literature that combined modality therapy is best practice . However, in this study, we were unable to demonstrate a survival benefit of adjuvant radiotherapy ( p = .597).…”

“…Patients in our cohort received 6‐month chest radiograph and neck ultrasound, with CT of the neck, chest, and abdomen performed at 18 months. As in other series, the majority of recurrences were locoregional (18 of 26) . However, because of the aggressive multimodality primary therapy received by our patients, treatment options for recurrence were limited, with only 7 of 26 patients (27%) successfully salvaged.…”

“…Of the 26 patients who experienced recurrence in our cohort, 50% (13 of 26) relapsed within 6.5 months and 92% (24 of 26) relapsed within 24 months of surgery. Other studies have reported a median time to recurrence of 8 to 15 months . Our data therefore suggest that intense follow‐up for at least 2 years postsurgery is warranted.…”

MicroRNA-17-5p regulated apoptosis-related protein expression and radiosensitivity in oral squamous cell carcinoma caused by betel nut chewing

“…Concurrent chemoradiation therapy has improved locoregional control and patient survival; however, locoregional failure remains a significant problem [52, 53]. Patients with individual head and neck cancers and advanced oral squamous cell carcinoma having tumors similar in sizes and stages may respond extremely differently to RT [54, 55]. …”

Prognostic markers in metastatic cutaneous squamous cell carcinoma of the head and neck

“…3 The majority of the cases of NMSC arise on the sun-exposed head and neck region. 8 Various prognostic parameters for overall survival (OS) in patients with node-positive head and neck cutaneous SCC have been demonstrated, including the presence and extent of nodal extracapsular extension (ECE), [9][10][11] total lymph node ratio (defined as the number of positive nodes divided by the total number of nodes resected), 12 the involvement of parotid lymph nodes, 3,13 differentiation of the primary tumor, 14 immunosuppression, 15 and margin status of the primary lesion. [4][5][6][7] In fact, head and neck cutaneous SCC is the most common parotid malignancy in Australia.…”