Predictors of outcome in outpatients with anxiety disorders: The Leiden routine outcome monitoring study

Schat, Anke; Noorden, Martijn S. van; Noom, Marc; Giltay, Erik J.; Wee, Nic J.A. van der; Vermeiren, Robert; Zitman, Frans G.

doi:10.1016/j.jpsychires.2013.09.005

Cited by 12 publications

(19 citation statements)

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“…When, after checking for collinearity, these variables were entered in multivariable logistic regression, panic disorder with or without agoraphobia (OR = 1.73; 95% CI = 1.29–2.31; p < .001), social phobia (OR = 0.57; 95% CI = 0.40–0.81; p = 0.002), cognitive distortion (OR = 1.20; 95% CI = 1.00–1.45; p = 0.05), and affective lability (OR = 1.50 95% CI = 1.15–1.95; p = .003) best predicted lower observed compared to self‐reported anxiety severity (Table ). When analyses were repeated with only those patients who met criteria for at least moderate severity (BAS ≥ 10.38 (Tyrer et al ., ; Schat et al ., )) and/or BSI‐12 ≥ 6 (Roy‐Byrne et al ., ; Schat et al ., ) ( n = 1,852) results did not change (results not shown).…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, as a sensitivity analysis, we repeated analyses with only those subjects who met criteria for at least moderate severity on either the BAS or the BSI‐12 so as to guarantee substantial anxiety severity. Moderate severity was defined as BAS ≥ 10.38 (Schat et al ., ; Tyrer et al ., ) and/or BSI‐12 ≥ 6 (Roy‐Byrne et al ., ; Schat et al ., ). We used SPSS version 20.0 (IBM Corp., Armonk, NY, USA).…”

Section: Methodsmentioning

confidence: 99%

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Concordance between self‐reported and observer‐rated anxiety severity in outpatients with anxiety disorders: The Leiden routine outcome monitoring study

et al. 2017

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Concordance between self‐reported and observer‐rated anxiety severity in outpatients with anxiety disorders: The Leiden routine outcome monitoring study

et al. 2017

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“…If the BSI-12 had been measured more often during the 18 months of follow-up, recurrence rates would have likely been higher and different predictors of anxiety recurrence may have been identified. However, other studies have similarly used the BSI to measure anxiety in long-term outcomes studies (Andreescu et al, 2007; Lang et al, 2006; Roy-Byrne et al, 2010; Schat et al, 2013). Finally, the differences between our analyzed sample and those excluded due to incomplete follow-up suggest our results may be more representative of patients who are older, more financially secure, less anxious, and prescribed fewer psychotropics.…”

Section: Discussionmentioning

confidence: 99%

“…We defined symptom remission as a 12-item Brief Symptom Inventory for anxiety and somatization (BSI-12) score < 6, consistent with prior studies (Roy-Byrne et al, 2010; Schat et al, 2013). The BSI-12 is a reliable and valid self-report measure of global anxiety and somatization symptoms in the past week (Derogatis and Melisaratos, 1983; Morlan and Tan, 1998) and has been used to measure anxiety in studies examining long-term outcomes (Andreescu et al, 2007; Lang et al, 2006; Schat et al, 2013). The BSI-12 sums the scores from 12 questions that are each scored 0-4 with higher scores indicating more severe symptoms.…”

Section: Methodsmentioning

confidence: 99%

Predictors of anxiety recurrence in the Coordinated Anxiety Learning and Management (CALM) trial

Taylor

Jakubovski

Bloch

2015

Journal of Psychiatric Research

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Few studies have examined anxiety recurrence after symptom remission in the primary care setting. We examined anxiety recurrence in the Coordinated Anxiety Learning and Management (CALM) trial. From 2006-2009, CALM randomized adults with anxiety disorders (generalized anxiety disorder, panic disorder, social anxiety disorder, and post-traumatic stress disorder) in primary care clinics to usual care (UC) or a collaborative care (CC) intervention of pharmacotherapy and/or cognitive behavioral therapy. We examined 274 patients who met criteria for anxiety remission (Brief Symptom Inventory for anxiety and somatization (BSI-12) < 6) after 6 months of randomized treatment and completed a follow-up of 18 months. Logistic regression and receiver operating characteristics (ROC) were used to identify predictors of anxiety recurrence (BSI-12 ≥ 6 and 50% increase from 6-month ratings) during the year following remission. Recurrence was lower in CC (29%) compared to UC (41%) (p = 0.04). Patients with comorbid depression or lower self-perceived socioeconomic status particularly benefited (in terms of reduced recurrence) if assigned to CC instead of UC. In the multivariable logistic regression model, smoking, being single, Anxiety Sensitivity Index score, functional impairment at month 6 due to residual anxiety (measured with the Sheehan Disability Scale), and treatment with benzodiazepines were associated with subsequent anxiety recurrence. ROC identified prognostic subgroups based on the risk of recurrence. Our study was exploratory, and our findings require replication. Future studies should also examine the effectiveness of relapse prevention programs in patients at highest risk for recurrence.

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“… 6 , 7 Many studies focused on sociodemographic factors that may positively influence treatment response. 8 …”

Section: Introductionmentioning

confidence: 99%

Coping strategies, hope, and treatment efficacy in pharmacoresistant inpatients with neurotic spectrum disorders

Ocisková

Praško

Kamarádová

et al. 2015

NDT

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BackgroundApproximately 30%–60% of patients with neurotic spectrum disorders remain symptomatic despite treatment. Identifying the predictors of good response to psychiatric and psychotherapeutic treatment may be useful for increasing treatment efficacy in neurotic patients. The objective of this study was to investigate the influence of hope, coping strategies, and dissociation on the treatment response of this group of patients.MethodsPharmacoresistant patients, who underwent a 6-week psychotherapeutic program, were enrolled in the study. All patients completed the Clinical Global Impression (CGI) – both objective and subjective forms, Beck Anxiety Inventory (BAI), and Beck Depression Inventory (BDI)-II at baseline and after 6 weeks. The COPE Inventory, the Adult Dispositional Hope Scale (ADHS), and the Dissociative Experiences Scale (DES) were completed at the start of the treatment.ResultsSeventy-six patients completed the study. The mean scores for all scales measuring the severity of the disorders (BAI, BDI-II, subjective and objective CGI) significantly decreased during the treatment. Several subscores of the COPE Inventory, the overall score of ADHS, and the overall score of DES significantly correlated with the treatment outcome. Multiple regression was used to find out which factors were the most significant predictors of the therapeutic outcomes. The most important predictors of the treatment response were the overall levels of hope and dissociation.ConclusionAccording to our results, a group of patients with a primary neurotic disorder, who prefer the use of maladaptive coping strategies, feel hopelessness, and have tendencies to dissociate, showed poor response to treatment.

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Predictors of outcome in outpatients with anxiety disorders: The Leiden routine outcome monitoring study

Cited by 12 publications

References 56 publications

Concordance between self‐reported and observer‐rated anxiety severity in outpatients with anxiety disorders: The Leiden routine outcome monitoring study

Concordance between self‐reported and observer‐rated anxiety severity in outpatients with anxiety disorders: The Leiden routine outcome monitoring study

Predictors of anxiety recurrence in the Coordinated Anxiety Learning and Management (CALM) trial

Coping strategies, hope, and treatment efficacy in pharmacoresistant inpatients with neurotic spectrum disorders

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