Predictors of Outcome in Henoch-Schönlein Nephritis in Children and Adults

Coppo, Rosanna; Andrulli, Simeone; Amore, Alessandro; Gianoglio, Bruno; Conti, Giovanni; Peruzzi, Licia; Locatelli, Francesco; Cagnoli, L

doi:10.1053/j.ajkd.2006.02.178

Cited by 214 publications

(178 citation statements)

References 22 publications

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“…Renal involvement has been reported to occur in 20% to 54% of children with HSP and can range from isolated hematuria and/or proteinuria to a more severe clinical course including acute nephritis, nephrotic syndrome, or even rapidly progressive glomerulonephritis (2,3,5,9 -14). For the majority of pediatric patients with HSP, renal involvement is relatively benign and self-limited (15). However, it has been estimated that up to 20% of children with HSP nephritis can develop chronic kidney disease with up to 2% progressing to ESRD and ultimately requiring renal transplantation (4,10 -12,16 -19).…”

Section: Introductionmentioning

confidence: 99%

Long-term Outcome of Renal Transplantation Patients with Henoch-Schönlein Purpura

Samuel¹,

Bell²,

Molony³

et al. 2011

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives Although Henoch-Schö nlein purpura (HSP) is the most common form of renal vasculitis in childhood, progression to ESRD is rare, and there are few data on outcomes of renal transplantation in patients with HSP.Design, setting, participants, & measurements This is a matched retrospective cohort study of renal allografts using the United Network of Organ Sharing database (1987 to 2005). Of the 189,211 primary renal allografts, there were 339 with a diagnosis of HSP. The primary end point was allograft survival. ResultsCompared with the remainder of the database, the HSP population was younger (25 years versus 46 years), and had a higher proportion of women (47% versus 40%), live donors (50% versus 35%), and Caucasians (77% versus 60%). Controlling for age, gender, donor source, ethnicity, and year of transplantation, death-censored graft survival for patients with HSP was 80.0% at 5 years and 58.8% at 10 years compared with 79.0% at 5 years and 55.4% at 10 years in the non-HSP population. Among patients with reported causes of graft loss, failure from recurrent disease occurred in 13.6% of patients with HSP, compared with 6.6% in the non-HSP population. When analyzing allograft survival in recipients with HSP compared with those with IgA nephropathy, there was no difference in 10-year allograft survival (58.4% and 59.3%, respectively). ConclusionsThese data indicate that although there is an increased risk of graft failure attributable to recurrent disease in patients with HSP, a diagnosis of HSP has little effect on overall renal allograft survival.

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Section: Introductionmentioning

confidence: 99%

Long-term Outcome of Renal Transplantation Patients with Henoch-Schönlein Purpura

Samuel¹,

Bell²,

Molony³

et al. 2011

Clinical Journal of the American Society of Nephrology

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“…ANCA-negative patients have more severe glomerular lesions (20) and severe chronic lesions, including interstitial fibrosis and glomerulosclerosis (8,19), than their ANCA-positive counterparts. These findings have been attributed to a delay in diagnosis by the lack of systemic symptoms and negative ANCAs seen in these patients (9,20). Our patient had focal and crescentic phenotypes; however, the presence of the glomerulosclerosis pattern precludes a poor renal prognosis.…”

Section: Discussionmentioning

confidence: 66%

“…Normocomplementemic glomerulonephritides include IgA nephropathy, IgA vasculitis (Henoch-Schönlein) (IgAV), and fibrillary glomerulonephritis. This elderly patient had none of the classic features of IgAV such as palpable purpura and gastrointestinal manifestations, including abdominal pain, bleeding, infarction, and intussusceptions (9). IgA nephropathy is the most common cause of glomerulonephritis, and symptoms can range from asymptomatic hematuria to RPGN (10).…”

Section: Differential Diagnosismentioning

confidence: 95%

“…She had periorbital edema as well as bilateral lower extremity pitting edema to the knees. Laboratory evaluation in the emergency room showed normocytic anemia, blood urea nitrogen of 44 mg/dl (normal range [7][8][9][10][11][12][13][14][15][16][17][18], and a creatinine level of 3.8 mg/dl (normal range 0.6 -1.2). Her estimated creatinine clearance was 11.9 ml/minute/1.73 m 2 (normal range 80 -125) with a fractional excretion of sodium of 2.5%.…”

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An Unusual Case of Hematuria

Najem

Sfeir

Estrada

et al. 2014

Arthritis Care & Research

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“…While HSP, progresses without complications in mild cases, in severe cases complications in the gastrointerstinal system in acute phase, and renal complications in chronic phase determine the prognosis [2]. While some publications have reported that the determination of nephrotic range proteinuria during first presentation or the deterioration of kidney function is a risk factor for renal failure within 20 years following diagnosis [2][3][4][5][6][7][8], in an Italian cohort study, the authors showed that early symptoms are not significant in determining the prognosis [2,9,10].…”

Section: Introductionmentioning

confidence: 99%

Tooth fragments embedded in the lower lip following trauma

Benzer¹,

Duramaz²,

Önal³

et al. 2015

MMJ

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Objectives: Henoch-Schönlein purpura (HSP) or IgA vasculitis, is the most common form of childhood vasculitis. Mean platelet volume (MPV) is a parameter of a complete blood count that shows thrombocyte function and activation. This study evaluated the link between MPV and HSP. Patients and Methods:The data of 75 patients with a diagnosis of HSP were retrospectively evaluated. A control group was formed with 79 healthy children of similar gender and ages. results:The average ages were 6.8±3.02 years (44 males, 31 females) and 7.49±2.95 years (40 males, 39 females) for the patient and control groups respectively. Mean platelet volume was found to be significantly lower in the study group (p<0.0001). Patients' thrombocyte count were significantly higher (p<0.0001). Upon presentation 18 patients' faecal occult blood (FOB) test results were positive, and there was microscopic hematuria in 12 patients, MPV was found to be significantly lower in FOB positive patients (p=0.043).conclusion: Inflammation may affect MPV levels by increasing or decreasing. In our study, MPV measurements performed by a cheap and simple method, have been considered as a negative acute phase reactant. Decreased MPV measurements despite increased platelet count may be important in the prediction of hypercoagulopathy problems during the likely course of the disease and in close follow up for those with a predisposition. Ortalama trombosit hacmi çalışma grubunda anlamlı derecede düşük saptandı (p<0,0001). Hastaların trombosit sayısı anlamlı derecede yüksek bulundu (p<0,0001). Başvuru anında 18 hastada gizli gaite kan (GGK) testi pozitifti ve 12 hastada mikroskopik hematüri mevcuttu, GGK pozitif olan hastalarda OTH anlamlı düşük bulundu (p=0,043). sonuç: İnflamasyon, OTH düzeyini artma/azalma şeklinde etkileyebilmektedir. Çalışmamızda ucuz ve basit bir yöntem olan OTH ölçümleri negatif akut faz reaktanı olarak değerlendirilmiştir. Henoch-Schönlein purpuralı çocuklarda, artmış trombosit sayısına karşın, azalmış OTH ölçümlerinin, yatkınlığı olanlarda, hastalık seyrindeki olası hiperkoagülopati problemlerinin önceden belirlenmesinde ve yakın takipte önemli olabileceği kanısına varılmıştır.

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Predictors of Outcome in Henoch-Schönlein Nephritis in Children and Adults

Cited by 214 publications

References 22 publications

Long-term Outcome of Renal Transplantation Patients with Henoch-Schönlein Purpura

Long-term Outcome of Renal Transplantation Patients with Henoch-Schönlein Purpura

An Unusual Case of Hematuria

Tooth fragments embedded in the lower lip following trauma

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